Characterization of an HPV-negative cell line (FR-car) derived from a cervical squamous intraepithelial lesion

1998 ◽  
Vol 34 (9) ◽  
pp. 729-733
Author(s):  
Carolien van Haaften-Day ◽  
Barbara Rose ◽  
Carol Thompson ◽  
Robyn Lukeis ◽  
Peter Russell
Keyword(s):  
Cell Line ◽  
Squamous Intraepithelial Lesion ◽  
Negative Cell ◽  
Intraepithelial Lesion ◽  
Cervical Squamous Intraepithelial Lesion ◽  
Negative Cell Line

scholarly journals Separation of Normal and Premalignant Cervical Epithelial Cells Using Confocal Light Absorption and Scattering Spectroscopic MicroscopyEx Vivo

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Ling Yang ◽  
Wen-Tao Liu ◽  
Hao Wu ◽  
Cheng Wang ◽  
Bo Ping ◽  
...  
Keyword(s):  
Light Absorption ◽  
Pap Smear ◽  
Precancerous Lesions ◽  
Scattered Light ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Cervical Lesions ◽  
Pap Smear Test ◽  
Intraepithelial Lesion ◽  
Cervical Squamous Intraepithelial Lesion

Confocal light absorption and scattering spectroscopic (CLASS) microscopy can detect changes in biochemicals and the morphology of cells. It is therefore used to detect high-grade cervical squamous intraepithelial lesion (HSIL) cells in the diagnosis of premalignant cervical lesions. Forty cervical samples from women with abnormal Pap smear test results were collected, and twenty cases were diagnosed as HSIL; the rest were normal or low-grade cervical squamous intraepithelial lesion (LSIL). The enlarged and condensed nuclei of HSIL cells as viewed under CLASS microscopy were much brighter and bigger than those of non-HSIL cells. Cytological elastic scattered light data was then collected at wavelengths between 400 and 1000 nm. Between 600 nm to 800 nm, the relative elastic scattered light intensity of HSIL cells was higher than that of the non-HSIL. Relative intensity peaks occurred at 700 nm and 800 nm. CLASS sensitivity and specificity results for HSIL and non-HSIL compared to cytology diagnoses were 80% and 90%, respectively. This study demonstrated that CLASS microscopy could effectively detect cervical precancerous lesions. Further study will verify this conclusion before the method is used in clinic for early detection of cervical cancer.

scholarly journals HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

2020 ◽  
Vol 16 (1) ◽  
pp. 87-93
Author(s):  
Piotr Lewitowicz ◽  
Anna Nasierowska-Guttmejer ◽  
Wojciech Rokita ◽  
Olga Adamczyk-Gruszka ◽  
Stanisław Gluszek ◽  
...  
Keyword(s):  
Detection Rate ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Ki 67 ◽  
Hpv Genotyping ◽  
Intraepithelial Lesion ◽  
Cervical Squamous Intraepithelial Lesion

Complement Component C1q and Anti-hexon Antibody Mediate Adenovirus Infection of a CAR-Negative Cell Line

2008 ◽  
Vol 21 (4) ◽  
pp. 469-476 ◽  
Author(s):  
Van Tsai ◽  
Robin Varghese ◽  
Sundari Ravindran ◽  
Robert Ralston ◽  
Gary Vellekamp
Keyword(s):  
Cell Line ◽  
Complement Component ◽  
Adenovirus Infection ◽  
Negative Cell ◽  
Negative Cell Line
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