Mountain ecosystems are significantly affected by climate change. However, due to slow vegetation growth in mountain ecosystems, climate-induced vegetation shifts are difficult to detect with low-definition remote sensing images. We used high-definition remote sensing data to identify responses to climate change in a typical Picea crassifolia Kom. forest in the Qilian Mountains, China, from 1968 to 2017. We found that: (1) Picea crassifolia Kom. forests were distributed in small patches or strips on shaded and partly shaded slopes at altitudes of 2700–3250 m, (2) the number, area, and concentration of forest patches have been increasing from 1968 to 2017 in relatively flat and partly sunny areas, but the rate of area increase and ascend of the tree line slowed after 2008, and (3) the establishment of plantation forests may be one of the reasons for the changes. The scale of detected change in Picea crassifolia Kom.forest was about or slightly below 30 m, indicating that monitoring with high-resolution remote sensing data will improve detectability and accuracy.