study on the protective effect of the Mixture of Shengmai Powder and Danshen Decoction (生脉散丹参饮合剂) on the myocardium of diabetic cardiomyopathy in the rat model

2011 ◽  
Vol 17 (2) ◽  
pp. 116-125 ◽  
Author(s):  
Qing Ni ◽  
Jie Wang ◽  
En-qing Li ◽  
An-bin Zhao ◽  
Bin Yu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Cardiomyopathy ◽  
Rat Model

scholarly journals The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy

2010 ◽  
Vol 12 (10) ◽  
pp. 1051-1060 ◽  
Author(s):  
Dae-Hee Kim ◽  
Yong-Jin Kim ◽  
Sung-A Chang ◽  
Hye-Won Lee ◽  
Ha-Na Kim ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Protective Effect ◽  
Ventricular Function ◽  
Diabetic Cardiomyopathy ◽  
Rat Model ◽  
Left Ventricular

scholarly journals Ultrasound-targeted Microbubble Destruction Promotes Myocardial Angiogenesis and Functional Improventments in Rat Model of Diabetic Cardiomyopathy

2020 ◽  
Author(s):  
Xijun Zhang ◽  
Haohui Zhu ◽  
Nanqian Zhou ◽  
Zhixin Fang ◽  
Yuping Yang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Cardiomyopathy ◽  
Rat Model ◽  
Critical Role ◽  
Therapeutic Angiogenesis ◽  
Diabetic Patients ◽  
Therapeutic Effects ◽  
Novel Approach ◽  
Cardiac Functions ◽  
Cycle Group

Abstract Objective: Microvascular insufficiency takes a critical role in the development of diabetic cardiomyopathy (DCM), therapeutic angiogenesis has been mainly used for the treatment of ischemic diseases. The present study sought to investigate the preclinical performance of SonoVue microbubbles(MBs) combined ultrasound(US) treatment on myocardial angiogenesis in a rat model of DCM and investigate the optimal ultrasonic parameters.Methods and Results: After the DCM model was established, the cardio protective effect of SonoVue MBs using US techniques was examined by histology, morphometry, and echocardiography evaluations. From morphologic observation and echocardiography, the DCM rats had a set of structural abnormalities in the heart compared to the normal rats. The US-MB groups exerted cardio protective effect in DCM rats, improved reparative neovascularization and increased cardiac perfusion, while the 26 cycle group showed significantly therapeutic effects on the cardiac functions in DCM rats.Conclusion: This strategy using SonoVue MB and US can significantly improve or even reverse cardiac dysfunction and pathological abnormalities, especially using the 26 cycle parameters. Under further study, this combined strategy might provide a novel approach for early intervention of DCM in diabetic patients.

scholarly journals Erratum to: Heart-protective effect of n-3 PUFA demonstrated in a rat model of diabetic cardiomyopathy

2014 ◽  
Vol 392 (1-2) ◽  
pp. 299-299
Author(s):  
Anna Zhukovska ◽  
Angela Shysh ◽  
Barbara Bacova ◽  
Jana Radosinska ◽  
Tamara Benova ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Cardiomyopathy ◽  
Rat Model

Heart-protective effect of n-3 PUFA demonstrated in a rat model of diabetic cardiomyopathy

2013 ◽  
Vol 389 (1-2) ◽  
pp. 219-227 ◽  
Author(s):  
Zhukovska Anna ◽  
Shysh Angela ◽  
Bacova Barbara ◽  
Radosinska Jana ◽  
Benova Tamara ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Cardiomyopathy ◽  
Rat Model

Novel "Dual Hit" Rat Model of Diabetic Cardiomyopathy

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 466-P ◽  
Author(s):  
LOUISE THISTED ◽  
ROSS T. LINDSAY ◽  
KELD FOSGERAU ◽  
THOMAS SECHER ◽  
MORTEN B. THOMSEN ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Rat Model

Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats

2020 ◽  
Vol 18 (3) ◽  
pp. 260-265
Author(s):  
Xu Lin ◽  
Zheng Xiaojun ◽  
Lv Heng ◽  
Mo Yipeng ◽  
Tong Hong
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Protective Effect ◽  
Infarct Size ◽  
Rat Model ◽  
Left Ventricular ◽  
Related Factor ◽  
Nuclear Factor ◽  
Internal Dimension

The purpose of this study was to evaluate the protective effect of swertiamarin on heart failure. To this end, a rat model of heart failure was established via left coronary artery ligation. Infarct size of heart tissues was determined using triphenyl tetrazolium chloride staining. Echocardiography was performed to evaluate cardiac function by the determination of ejection fraction, left ventricular internal dimension in diastole and left ventricular internal dimension in systole. The effect of swertiamarin on oxidative stress was evaluated via enzyme-linked immunosorbent assay. The mechanism was evaluated using western blot. Administration of swertiamarin reduced the infarct size of heart tissues in rat models with heart failure. Moreover, swertiamarin treatment ameliorated the cardiac function, increased ejection fraction and fractional shortening, decreased left ventricular internal dimension in diastole and left ventricular internal dimension in systole. Swertiamarin improved oxidative stress with reduced malondialdehyde, while increased superoxide dismutase, glutathione, and GSH peroxidase. Furthermore, nuclear-factor erythroid 2-related factor 2, heme oxygenase and NAD(P)H dehydrogenase (quinone 1) were elevated by swertiamarin treatment in heart tissues of rat model with heart failure. Swertiamarin alleviated heart failure through suppression of oxidative stress response via nuclear-factor erythroid 2-related factor 2/heme oxygenase-1 pathway providing a novel therapeutic strategy for heart failure.

Contractile dysfunction accompanied by altered gene expression and CA2+-handling in a rat model of diabetic cardiomyopathy

2001 ◽  
Vol 33 (6) ◽  
pp. A179
Author(s):  
Han A.A. van Heugten ◽  
Karel Bezstarosti ◽  
Ruud van Hof ◽  
Regien G. Schoemaker ◽  
Jos M.J. Lamers
Keyword(s):  
Gene Expression ◽  
Diabetic Cardiomyopathy ◽  
Rat Model ◽  
Contractile Dysfunction ◽  
Altered Gene Expression ◽  
Altered Gene
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