scholarly journals Epidemiology of hip fractures in Bulgaria: development of a country-specific FRAX model

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
E. Kirilova ◽  
H. Johansson ◽  
N. Kirilov ◽  
S. Vladeva ◽  
T. Petranova ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Population Based ◽  
Fracture Probability ◽  
Regional Health ◽  
National Mortality ◽  
Bulgarian Population ◽  
Specific Fracture ◽  
Country Specific ◽  
Population Based Survey

Abstract Summary A retrospective population-based survey was undertaken in a region of Bulgaria to determine the incidence of hip fracture. The estimated number of hip fractures nationwide for 2015 was 9322 and is predicted to increase to 11,398 in 2050. The hip fracture rates were used to create a FRAX model. Objective To describe the epidemiology of hip fractures in Bulgaria, which was then used to develop the country-specific fracture prediction FRAX® tool. Methods We carried out a retrospective population-based survey in Stara Zagora, Bulgaria, representing approximately 4.6% of the country’s population. We identified hip fractures occurring in 2015, 2016 and 2017 from hospital registers and primary care sources held by the regional health insurance agency. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Bulgaria. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 9322 and is predicted to increase to 11,398 in 2050. FRAX-based probabilities were higher in Bulgaria than those in Serbia or Romania, lower than those in Turkey and similar to those in Greece. Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Bulgarian population and help guide decisions about treatment.

scholarly journals Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alla Zakroyeva ◽  
Olga Lesnyak ◽  
Victor Cazac ◽  
Liliana Groppa ◽  
Eugen Russu ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Fracture Probability ◽  
Republic Of Moldova ◽  
National Mortality ◽  
The Republic ◽  
Specific Fracture ◽  
Country Specific ◽  
Population Based Survey

Abstract Summary Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment. Objective This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool. Methods We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania). Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.

scholarly journals Epidemiology of hip fracture and the development of a FRAX model for Uzbekistan

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
O Lesnyak ◽  
S Ismailov ◽  
M Shakirova ◽  
N Alikhanova ◽  
A Zakroyeva ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Mortality Rates ◽  
Population Based ◽  
Fracture Probability ◽  
Medical Attention ◽  
National Mortality ◽  
The Republic ◽  
Country Specific ◽  
Population Based Survey

Abstract Summary A prospective population-based survey in a region of the Republic of Uzbekistan determined the incidence of fractures at the hip. The hip fracture rates were used to create a FRAX® model to facilitate fracture risk assessment in Uzbekistan. Objective This paper describes the epidemiology of hip fracture in the Republic of Uzbekistan that was used to develop a country-specific FRAX® tool for fracture prediction. Methods During a 1-year (2016/17) prospective population-based survey in the Pap district of the Republic of Uzbekistan, hip fractures were prospectively identified from hospital registers, trauma centres and primary care and community sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Uzbekistan. Fracture probabilities were compared with those from neighbouring Kazakhstan and Kyrgystan. Results Approximately 41% of hip fracture cases did not come to medical attention, and two thirds of patients overall were not admitted to hospital. The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 16,764 and is predicted to increase more than three-fold to 60,272 in 2050. FRAX-based probabilities were higher in Uzbekistan than Kazakhstan or Kyrgystan. Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Uzbek population and help guide decisions about treatment.

scholarly journals Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Issayeva ◽  
O. Lesnyak ◽  
A. Zakroyeva ◽  
B. Issayeva ◽  
D. Dilmanova ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Trauma Centre ◽  
Fracture Incidence ◽  
Hip Fracture Incidence ◽  
The Republic ◽  
Country Specific ◽  
Population Based Survey

Abstract Summary Retrospective and prospective population-based survey in a region of the Republic of Kazakhstan determined the incidence of fractures at the hip, proximal humerus and distal forearm. The hip fracture rates were used to create a FRAX® model to enhance fracture risk assessment in Kazakhstan. Objective This paper describes the epidemiology of osteoporotic fractures in the Republic of Kazakhstan that was used to develop a country specific FRAX® tool for fracture prediction. Methods We carried out a retrospective population-based survey in Taldykorgan in the Republic of Kazakhstan representing approximately 1% of the country’s population. Hip, forearm and humerus fractures were identified retrospectively in 2015 and 2016 from hospital registers and the trauma centre. Hip fractures were prospectively identified in 2017 from the same sources and additionally from primary care data. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Kazakhstan. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results The difference in hip fracture incidence between the retrospective and prospective survey indicated that approximately 25% of hip fracture cases did not come to hospital attention. The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 11,690 and is predicted to increase by 140% to 28,000 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures in men but not in women. Conclusion The FRAX model should enhance accuracy of determining fracture probability among the Kazakh population and help guide decisions about treatment.

scholarly journals Epidemiology of hip fracture in Botswana

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
M. Kebaetse ◽  
S. Nkhwa ◽  
M. Mogodi ◽  
J. Masunge ◽  
Y. P. Gureja ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Chart Review ◽  
Population Based ◽  
Men And Women ◽  
Patient Chart ◽  
Number Of Patients ◽  
The Republic ◽  
Age And Sex ◽  
Population Based Survey

Abstract Summary A retrospective population-based survey in the Republic of Botswana determined the incidence of fractures at the hip over 3 years. The estimated number of such fractures nationwide for 2020 was 103 and is predicted to increase. Objective This article describes the epidemiology of hip fractures in the Republic of Botswana. Methods A retrospective patient chart review was conducted to identify from hospital registers the number of patients diagnosed with hip fracture in 2009, 2010, and 2011. Age- and sex-specific incidence of hip fracture was determined from which lifetime probabilities and future projections for hip fracture were calculated. Results The incidence of hip fracture was low and comparable to rates reported from Tunisia. The remaining lifetime risk of hip fracture at the age of 50 years in men and women was 1.4 and 1.1%, respectively. The incidence of hip fracture suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2020 was 103 and is predicted to increase by more than threefold to 372 in 2050. Conclusion The hip fracture rates can be used for healthcare planning. Additionally, these data can be used to create a FRAX model to help guide decisions about treatment.

scholarly journals Milk drinking and risk of hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS)

2019 ◽  
Vol 121 (6) ◽  
pp. 709-718 ◽  
Author(s):  
Kristin Holvik ◽  
Haakon E. Meyer ◽  
Ida Laake ◽  
Diane Feskanich ◽  
Tone K. Omsland ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Cox Regression ◽  
Population Based ◽  
Third Wave ◽  
Hospital Data ◽  
High Fracture ◽  
Hazard Ratios ◽  
Meta Analyses

AbstractMilk provides energy and nutrients considered protective for bone. Meta-analyses of cohort studies have found no clear association between milk drinking and risk of hip fracture, and results of recent studies are contradictory. We studied the association between milk drinking and hip fracture in Norway, which has a population characterised by high fracture incidence and a high Ca intake. Baseline data from two population-based cohorts were used: the third wave of the Norwegian Counties Study (1985–1988) and the Five Counties Study (2000–2002). Diet and lifestyle variables were self-reported through questionnaires. Height and weight were measured. Hip fractures were identified by linkage to hospital data with follow-up through 2013. Of the 35 114 participants in the Norwegian Counties Study, 1865 suffered a hip fracture during 613 018 person-years of follow-up. In multivariable Cox regression, hazard ratios (HR) per daily glass of milk were 0·97 (95 % CI 0·92, 1·03) in men and 1·02 (95 % CI 0·96, 1·07) in women. Of 23 259 participants in the Five Counties Study, 1466 suffered a hip fracture during 252 996 person-years of follow-up. HR for hip fractures per daily glass of milk in multivariable Cox regression was 0·99 (95 % CI 0·92, 1·07) in men and 1·02 (95 % CI 0·97, 1·08) in women. In conclusion, there was no overall association between milk intake and risk of hip fracture in Norwegian men and women.

scholarly journals Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

2021 ◽  
Vol 18 (16) ◽  
pp. 8780
Author(s):  
Bastien Bourrion ◽  
Cécile Souty ◽  
Lucie Fournier ◽  
Ana-Maria Vilcu ◽  
Thierry Blanchon ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Hip Fractures ◽  
Primary Outcome ◽  
Real Life ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Medication Persistence ◽  
Population Based Study ◽  
Osteoporotic Hip Fracture ◽  
Overall Effectiveness

Bisphosphonates are widely used in the treatment of women at risk of osteoporotic hip fracture; however, the overall effectiveness of bisphosphonates in the prevention of osteoporotic fractures has not been studied in real life. To investigate whether the use of bisphosphonates in women aged 50 years and over is associated with a decrease in hospitalization for osteoporotic hip fractures, a historical prospective cohort study was conducted between 2009 and 2016 from a permanent representative sample consisting of 1/97 of the French health insurance beneficiaries. Bisphosphonate use was defined according to medication persistence and adherence regarding bisphosphonate dispensations. The primary outcome was the hospitalization rate for osteoporotic hip fracture. Among the 81,268 women included, 2005 were exposed to bisphosphonates. The median time of bisphosphonate exposure was 12 (IQR, 3–29) and 17 (IQR, 5–42) months for the persistence and adherence definitions, respectively. Exposure to bisphosphonates was not associated with a decrease in hospitalization for hip fracture: weighted HRadherence = 0.66 (95% CI, 0.33 to 1.33); HRpersistance = 0.77 (95% CI, 0.38 to 1.57). In real life, bisphosphonate use does not appear to reduce hospitalization for hip fractures, as to date, it is probably prescribed as primary prevention and for a duration too short to be effective.

scholarly journals A surrogate FRAX model for the Kyrgyz Republic

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
O. Lesnyak ◽  
A. Zakroyeva ◽  
O. Lobanchenko ◽  
H. Johansson ◽  
E. Liu ◽  
...  
Keyword(s):  
Hip Fracture ◽  
International Society ◽  
Rank Order ◽  
Fracture Probability ◽  
Kyrgyz Republic ◽  
Death Risk ◽  
Risk Of Death ◽  
Neighbouring Country ◽  
Country Specific ◽  
Kyrgyz Population

Abstract Summary The hip fracture rates from Kazakhstan were used to create a surrogate FRAX® model for the Kyrgyz Republic. Introduction The International Society for Clinical Densitometry and International Osteoporosis Foundation recommend utilizing a surrogate FRAX model, based on the country-specific risk of death, and fracture data based on a country where fracture rates are considered to be representative of the index country. Objective This paper describes a surrogate FRAX model for the Kyrgyz Republic. Methods The FRAX model used the incidence of hip fracture from the neighbouring country of Kazakhstan and the death risk for the Kyrgyz Republic. Results Compared with the model for Kazakhstan, the surrogate model gave somewhat higher 10-year fracture probabilities for men between 60 and 80 years of age and lower probabilities for men above the age of 80. For women the probabilities were similar up to the age of 75–80 years and then lower. There were very close correlations in fracture probabilities between the surrogate and authentic models (1.00) so that the use of the Kyrgyz model had little impact on the rank order of risk. It was estimated that 2752 hip fractures arose in 2015 in individuals over the age of 50 years in the Kyrgyz Republic, with a predicted increase by 207% to 8435 in 2050. Conclusion The surrogate FRAX model for the Kyrgyz Republic provides the opportunity to determine fracture probability among the Kyrgyz population and help guide decisions about treatment.

scholarly journals A country-specific FRAX model for Botswana

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
M. Kebaetse ◽  
S. Nkhwa ◽  
M. Mogodi ◽  
J. Masunge ◽  
Y. P. Gureja ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Hip Fracture ◽  
Fragility Fractures ◽  
Mortality Rates ◽  
African Countries ◽  
Major Osteoporotic Fracture ◽  
National Mortality ◽  
Prevention And Treatment ◽  
The Usa ◽  
Country Specific

Abstract Introduction Hip fracture rates in Botswana were used to create a FRAX® model for fracture risk assessment. Objective This paper describes the development and characteristics of a country-specific FRAX model for Botswana. Methods Age-specific and sex-specific incidence of hip fracture and national mortality rates was incorporated into a FRAX model for Botswana. Ten-year fracture probabilities were compared with those from African countries having a FRAX model and African Americans from the USA. Results The probabilities of hip fracture and major osteoporotic fracture were low compared with those from South Africa (Black and Coloured) and US Blacks. Probabilities were marginally higher than for Tunisia. Conclusion The creation of a FRAX model is expected to help guide decisions about the prevention and treatment of fragility fractures in Botswana.

scholarly journals Cervical Hip Fracture in Afinnish Population: Incidence and Mortality

2009 ◽  
Vol 98 (3) ◽  
pp. 180-188 ◽  
Author(s):  
J. Panula ◽  
H. Pihlajamäki ◽  
M. Sävelä ◽  
P. T. Jaatinen ◽  
T. Vahlberg ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Lung Disease ◽  
Hip Fractures ◽  
Chronic Lung Disease ◽  
Population Based ◽  
Male Gender ◽  
Basic Material ◽  
Data Set ◽  
Incidence And Mortality ◽  
Evaluation Point

Background and Aims: Our aim was to describe the incidence of cervical hip fractures and to describe the relationships between selected background variables and mortality at 30 days, 6 months, and 3 years postoperatively. Material and Methods: The basic material consisted of population-based data set of patients aged 65 years or older who had sustained a hip fracture and were treated operatively between 1999 and 2000. Out of these, we identified 266 consecutive patients with cervical hip fracture. Results: The age-adjusted incidence of cervical hip fractures in women was 1.3-fold compared to men. In age-adjusted analysis, occurrence of chronic lung disease, cardiovascular disease or 2–5 comorbidities, male gender, the need for 2-person mobility assistance, and poor ambulation postoperatively were associated with excess mortality at least at one evaluation point. Conclusions: Only chronic lung disease and male gender were independent predictors of increased mortality at each follow-up assessment in multivariate analysis.

scholarly journals Increased Risk for Hip Fractures among Patients with Cholangitis: A Nationwide Population-Based Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Chieh-Cheng Hsu ◽  
Horng-Chaung Hsu ◽  
Che-Chen Lin ◽  
Yu-Chiao Wang ◽  
Hsuan-Ju Chen ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Confidence Interval ◽  
Hip Fractures ◽  
Population Based ◽  
Hazard Ratio ◽  
Incidence Density ◽  
Cancer History ◽  
Increased Risk ◽  
Systemic Inflammatory Disease ◽  
Young Subjects

Background. Cholangitis is the infectious disease involving the biliary tract, which may induce systemic inflammation. Bone loss is a well-known sequelae after systemic inflammatory disease, and one grave complication after osteoporosis is hip fracture. We want to know whether cholangitis can contribute to increased risk of hip fracture. Methods. All the patients diagnosed with cholangitis since January 1, 2001, to December 31, 2009, were assessed. All the subjects with cancer history, traumatic accident, and previous fracture were excluded. We selected the controls without cholangitis and matched the controls to cholangitis patients by age, sex, osteoporosis, and the use of steroid for more than 30 days by approximately 1:4 ratio. Results. There were 2735 subjects in the cholangitis cohort and 10915 in the noncholangitis cohort. There were 101 hip fractures in the cholangitis cohort with the incidence density of 7.58 per 1000 person-years. As for the noncholangitis cohort, 366 individuals suffered from hip fracture with the incidence density of 5.86 per 1000 person-years. The risk of hip fracture was higher in the cholangitis cohort with a 1.29-fold increased risk than the noncholangitis cohort (hazard ratio = 1.29, 95% confidence interval = 1.03-1.61). The association between cholangitis and the hip fracture was more prominent among subjects less than 65 years (hazard ratio = 2.65, 95% confidence interval =1.30-5.39) and the subjects without comorbidities (hazard ratio = 3.01, 95% confidence interval = 1.42-6.41). Conclusions. Cholangitis is associated with higher risk for hip fracture, especially among young subjects free from medical comorbidities.

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