Adjustable Intragastric Balloons: A 12-Month Pilot Trial in Endoscopic Weight Loss Management

Alcohol (i.e., ethanol) is consumed regularly by much of the adult population; yet, the health effects associated with its use are not well-characterized. Clinical interventions to investigate the effects of moderate alcohol consumption on metabolic outcomes, including adiposity and cardiovascular risk factors, are limited and have yielded conflicting data. In addition, no study has reported the effects of routine alcohol intake during weight loss in a controlled feeding trial. We present the first randomized controlled pilot trial to investigate the effects of moderate alcohol consumption on metabolic outcomes during weight loss in women with obesity. Both groups consumed 30% energy restricted diets and were randomized to either an ethanol-free control (CTL) group or a group (EtOH) that consumed 35 g ethanol daily for eight weeks. Our findings demonstrate that, despite similar weight loss, the decrease in mean arterial pressure was attenuated in the EtOH group, relative to the CTL group (p = 0.02). In addition, decreases in other outcomes, including visceral adipose tissue (p = 0.23), circulating lipids (triglycerides (p = 0.11) and cholesterol (p = 0.11)), and uric acid (p = 0.07) tended to be attenuated with alcohol consumption. These pilot data provide potential evidence that moderate alcohol consumption may mitigate the beneficial effects of weight loss and support the need for larger Randomized Controlled Trials (RCTs) to better investigate the metabolic effects of moderate alcohol intake in humans.

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A telephone-supported cardiovascular lifestyle programme (CLIP) for lipid reduction and weight loss in general practice patients: a randomised controlled pilot trial

Public Health Nutrition ◽

10.1017/s1368980013000220 ◽

2013 ◽

Vol 17 (3) ◽

pp. 640-647 ◽

Cited By ~ 7

Author(s):

Keren Louise Stuart ◽

Belinda Wyld ◽

Kathryn Bastiaans ◽

Nigel Stocks ◽

Grant Brinkworth ◽

...

Keyword(s):

Blood Pressure ◽

Weight Loss ◽

General Practice ◽

General Practitioner ◽

Primary Prevention ◽

Waist Circumference ◽

Total Cholesterol ◽

Pilot Trial ◽

Control Group ◽

Call Centre

AbstractObjectiveTo evaluate a primary prevention care model using telephone support delivered through an existing health call centre to general practitioner-referred patients at risk of developing CVD, using objective measures of CVD risk reduction and weight loss.DesignParticipants were randomised into two groups: (i) those receiving a telephone-supported comprehensive lifestyle intervention programme (CLIP: written structured diet and exercise advice, plus seven telephone sessions with the Heart Foundation Health Information Service); and (ii) those receiving usual care from their general practitioner (control: written general lifestyle advice). Fasting plasma lipids, blood pressure, weight, waist circumference and height were assessed on general practice premises by a practice nurse at Weeks 0 and 12.SettingTwo general practices in Adelaide, South Australia.SubjectsForty-nine men and women aged 48·0 (sd5·88) years identified by their general practitioner as being at future risk of CVD (BMI = 33·13 (sd5·39) kg/m2; LDL cholesterol (LDL-C) = 2·66 (sd0·92) mmol/l).ResultsCLIP participants demonstrated significantly greater reductions in LDL-C (estimated mean (EM)= 1·98 (se0·17) mmol/l) and total cholesterol (EM = 3·61 (se0·21) mmol/l) at Week 12 when compared with the control group (EM = 3·23 (se0·18) mmol/l and EM = 4·77 (se0·22) mmol/l, respectively). There were no significant treatment effects for systolic blood pressure (F(1,45) = 0·28,P= 0·60), diastolic blood pressure (F(1,43) = 0·52,P= 0·47), weight (F(1,42) = 3·63,P= 0·063) or waist circumference (F(1,43) = 0·32,P= 0·577).ConclusionsIn general practice patients, delivering CLIP through an existing telephone health service is effective in achieving reductions in LDL-C and total cholesterol. While CLIP may have potential for wider implementation to support primary prevention of CVD, longer-term cost-effectiveness data are warranted.

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Initial Weight Loss after Restrictive Bariatric Procedures May Predict Mid-Term Weight Maintenance: Results From a 12-Month Pilot Trial

Bariatric Surgical Practice and Patient Care ◽

10.1089/bari.2014.0049 ◽

2015 ◽

Vol 10 (2) ◽

pp. 68-73 ◽

Cited By ~ 16

Author(s):

Marko Nikolić ◽

Ivan Kruljac ◽

Lora Kirigin ◽

Gorana Mirošević ◽

Neven Ljubičić ◽

...

Keyword(s):

Weight Loss ◽

Weight Maintenance ◽

Pilot Trial ◽

Initial Weight ◽

Initial Weight Loss

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Assessing the Feasibility of a Social Media to Promote Weight Management Engagement in Adolescents with Severe Obesity: Pilot Study (Preprint)

10.2196/preprints.8229 ◽

2017 ◽

Author(s):

Elizabeth Prout Parks ◽

Renee' H Moore ◽

Ziyi Li ◽

Chanelle T Bishop-Gilyard ◽

Andrew R Garrett ◽

...

Keyword(s):

Social Media ◽

Weight Loss ◽

Weight Management ◽

Severe Obesity ◽

Pilot Trial ◽

Treatment Engagement ◽

Clinic Visit ◽

Attrition Rates ◽

Medical Weight Management ◽

Use Of Social Media

BACKGROUND Severe obesity in adolescents has deleterious physical and psychological complications necessitating frequent multi-disciplinary clinic visits. Greater treatment engagement has been equated with weight-loss. However, traditional medical weight-loss programs for adolescents have high attrition rates. Social media is widely used by adolescents and may enhance medical weight management engagement and success. OBJECTIVE The first objective was to examine the acceptability and feasibility of using a private social media group as an adjunct to medical weight management in youth ages 14 to 20 years with severe obesity [body mass index (BMI) ≥ 35 kg/m2]. The second objective was to pilot test the use of social media to improve treatment engagement and decrease attrition rates. METHODS In this single arm, 12 week pre-post study, participants attended individual clinic visits and participated in a moderated private social media group that received nutrition, exercise, and behavior change social media communications or “posts” 3 to 4 times/week. Youth commented and/or liked posts from the moderator and each other. Social media engagement was measured with the number of likes and comments on social media. Clinic attrition was compared, measuring clinic visit attendance 12 weeks prior, during, and after the intervention with mixed linear regression models. Correlations of social media engagement with changes from baseline for BMI, BMI-z score, and psychosocial measures were fit. RESULTS All 13 enrolled youth completed the study and reported that the group was enjoyable, helpful, reinforced their weight management program, and would recommend using social media to support other youth. The pilot trial was acceptable and feasible. Youth mean weekly engagement (likes + comments) in social media was greater than once a day (8.6 ±3.6). Compared to 12 weeks prior to the intervention, there was no significant decrease in clinic visit attendance at the end of the intervention (M=.231, P=.69) or 12 weeks at the conclusion of the intervention (M=.589, P=.28). Increased social media comments correlated with weight change (r=–.633, P=.04). CONCLUSIONS This pilot trial demonstrated that the use of social media as an adjunct to medical weight management was feasible and acceptable to adolescents with severe obesity. Based upon these preliminary findings, social media may be an effective way to mitigate attrition from obesity treatment programs, and improve health outcomes in this high-risk population.

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Impact of Adjunctive Pharmacotherapy With Intragastric Balloons for the Treatment of Obesity

The American Surgeon ◽

10.1177/00031348211038579 ◽

2021 ◽

pp. 000313482110385

Author(s):

Amit Mehta ◽

Shawn Shah ◽

Enad Dawod ◽

Kaveh Hajifathalian ◽

Rekha Kumar ◽

...

Keyword(s):

Weight Loss ◽

Weight Regain ◽

Primary Outcome ◽

Lifestyle Changes ◽

Lifestyle Modifications ◽

Weight Loss Outcome ◽

Intragastric Balloons ◽

Academic Hospitals ◽

Treatment Of Obesity

Background We conducted this study to compare the weight loss outcome of intragastric balloons (IGBs) in conjunction with pharmacotherapy vs IGB and intensive lifestyle changes alone. Methods This was a multicenter, non-randomized, retrospective study involving 4 academic hospitals. Patients underwent IGB placement with or without concomitant anti-obesity pharmacotherapy. The primary outcome was percent total weight loss (TBWL) after IGB placement at 6 and 12 months. Results This study included 102 patients, with 23 patients (mean age 46.6 years, 82.6% female) treated with IGB/pharmacotherapy and 79 patients (mean age 46.0 years, 88.6% female) treated with IGB/lifestyle modifications. Patients had a 100% follow-up rate at 6 and 12 months. At 6 months following IGB placement, both groups achieved a similar %TBWL. At 12 months, %TBWL was greater in the IGB/pharmacotherapy group (12.6% ± 1.2 vs 9.7% ± 0.7, P = .04). 65.2% of patients achieved ≥10% TBWL at 12 months in the IGB/pharmacotherapy group, compared to 38.0% in the IGB/lifestyle group ( P < .05). The proportion of patients that achieved ≥15% weight loss at 12 months was also significantly different between the IGB/pharmacotherapy and IGB/lifestyle groups (30.4% vs 20.3%, P < .05). Discussion IGB with concomitant use of pharmacotherapy did not improve weight loss while the IGB was in place compared to IGB and lifestyle changes. However, patients receiving IGB with pharmacotherapy did have greater weight loss and diminished weight regain after balloon removal compared to those receiving just IGB and lifestyle changes.

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