Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Patients with Morbid Obesity and Normal Thyroid Function

Abstract Background As the incidence of secretory osteoporosis has increased, bone loss, osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and its possible underlying mechanisms were investigated. Methods We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and TSH and the bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different lengths of time. The related gene and protein expression levels were investigated. Results A comparison of the BMD between the high-level and low-level serum TSH groups showed that the TSH serum concentration was positively correlated with BMD. TSH at concentrations of 10 mU/mL and 100 mU/mL significantly increased the mRNA levels of ALP, COI1 and Runx2 compared with those of the control (P < 0.05, P < 0.01). Bone morphogenetic protein (BMP)2 activity was enhanced with both increased TSH concentration and increased time. The protein levels of Runx2 and osterix were increased in a dose-dependent manner. Conclusions The circulating concentrations of TSH and BMD were positively correlated with normal thyroid function in males. TSH promoted osteoblast proliferation and differentiation in rat primary osteoblasts.

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Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation

10.21203/rs.3.rs-47941/v1 ◽

2020 ◽

Author(s):

Tuo Deng ◽

Wenwen Zhang ◽

Yanling Zhang ◽

Mengqi Zhang ◽

Zhikun Huan ◽

...

Keyword(s):

Thyroid Function ◽

Thyroid Stimulating Hormone ◽

Mrna Levels ◽

Dependent Manner ◽

Osteoblast Proliferation ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Gene And Protein Expression ◽

Proliferation And Differentiation ◽

Stimulating Hormone

Abstract Background As the incidence of secretory osteoporosis increases, bone loss and osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and the underlying possible mechanisms were investigated. Methods We analyzed serum triiodothyronine (FT3), tetraiodothyronine (FT4), TSH and bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different times at each time point. The related gene and protein expression levels were investigated. Results Comparing the BMD between the high-level and low-level serum TSH group showed that TSH serum concentrations were positively correlated with BMD. TSH at concentrations of 10 mU/mL and 100 mU/mL significantly increased the mRNA levels of ALP, COI1 and Runx2 compared with those of the control (P < 0.05, P < 0.01). BMP2 activity was enhanced both with increased TSH concentration and with increased time. The protein levels of Runx2 and osterix were increased in a dose-dependent manner. Conclusions The circulating concentrations of TSH and BMD were positively correlated with normal thyroid function in males. TSH promoted osteoblast proliferation and differentiation in rat primary osteoblasts.

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Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Euthyroid Patients with Morbid Obesity

Nutrients ◽

10.3390/nu11051121 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1121 ◽

Cited By ~ 2

Author(s):

Paula Juiz-Valiña ◽

Elena Outeiriño-Blanco ◽

Sonia Pértega ◽

Bárbara María Varela-Rodriguez ◽

María García-Brao ◽

...

Keyword(s):

Bariatric Surgery ◽

Morbid Obesity ◽

Weight Loss ◽

Thyroid Stimulating Hormone ◽

Control Group ◽

Obese Patients ◽

Excess Bmi Loss ◽

Tsh Levels ◽

Over Time ◽

Stimulating Hormone

Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect of weight loss after bariatric surgery on thyroid-stimulating hormone (TSH) levels in euthyroid patients with morbid obesity. We performed an observational study, evaluating patients with morbid obesity submitted to bariatric surgery. We included 129 patients (92 women) and 31 controls (21 women). Clinical, anthropometric, biochemical, and hormonal parameters were evaluated. The primary endpoint was circulating TSH (µU/mL). Fasting TSH levels were higher in the obese group (3.3 ± 0.2) than in the control group (2.1 ± 0.2). The mean excessive body mass index (BMI) loss (EBMIL) 12 months after bariatric surgery was 72.7 ± 2.1%. TSH levels significantly decreased in the obese patients after surgery; 3.3 ± 0.2 vs. 2.1 ± 0.2 before and 12 months after surgery, respectively. Free thyroxine (T4) (ng/dL) levels significantly decreased in the obese patients after surgery; 1.47 ± 0.02 vs. 1.12 ± 0.02 before and 12 months after surgery, respectively. TSH decreased significantly over time, and the decrement was associated with the EBMIL. In euthyroid patients with morbid obesity, weight loss induced by bariatric surgery promotes a significant decline of the increased TSH levels. This decrement of TSH is progressive over time after surgery and significantly associated with excess BMI loss.

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919 THYROID-STIMULATING HORMONE SERUM LEVEL, LIVER THYROID-STIMULATING HORMONE-RECEPTOR, AND SEVERE FIBROSIS IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS WITH NORMAL THYROID FUNCTION

Journal of Hepatology ◽

10.1016/s0168-8278(12)60931-3 ◽

2012 ◽

Vol 56 ◽

pp. S358

Author(s):

S. Petta ◽

A. Mazzola ◽

S. Grimaudo ◽

C. Camma ◽

D. Cabibi ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Serum Level ◽

Thyroid Stimulating Hormone ◽

Genotype 1 ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Chronic Hepatitis C Patients ◽

Severe Fibrosis ◽

Stimulating Hormone

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Hashimoto’s thyroiditis in patients with normal thyroid-stimulating hormone levels

Expert Review of Endocrinology & Metabolism ◽

10.1586/eem.12.3 ◽

2012 ◽

Vol 7 (2) ◽

pp. 175-179 ◽

Cited By ~ 7

Author(s):

Regina Promberger ◽

Michael Hermann ◽

Johannes Ott

Keyword(s):

Hashimoto’S Thyroiditis ◽

Thyroid Stimulating Hormone ◽

Hashimoto's Thyroiditis ◽

Normal Thyroid ◽

Hormone Levels ◽

Stimulating Hormone

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Obesity and hypothyroidism

Obesity and metabolism ◽

10.14341/2071-8713-4826 ◽

2013 ◽

Vol 10 (2) ◽

pp. 54-58 ◽

Cited By ~ 1

Author(s):

S M Zakharova ◽

L V Savelieva ◽

M I Fadeeva

Keyword(s):

Weight Loss ◽

Energy Expenditure ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Thyroid Stimulating Hormone ◽

Overt Hypothyroidism ◽

Obese Patients ◽

Common Diseases ◽

The Relationship ◽

Stimulating Hormone

Obesity and hypothyroidism are common diseases, and consequently clinicians should be particularly alert to the possibility of thyroid dysfunction in obese patients. The relationship between thyroid function and obesity is likely to be bidirectional, with hypothyroidism affecting weight, but obesity also influencing thyroid function. Both serum thyroid-stimulating hormone and fT3 are typically increased in obese individuals, an effect likely mediated by leptin. Following L-T4 treatment for overt hypothyroidism, weight loss appears to be modest and mediated primarily by loss of water weight rather than fat. Selected thyroid analogs might be a means by which to improve weight loss by increasing energy expenditure in obese patients during continued caloric deprivation

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Correlation Between the Thyroid Hormone Levels and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients with Normal Thyroid Function

10.21203/rs.3.rs-58794/v1 ◽

2020 ◽

Author(s):

Yuanyuan Zhang ◽

Huaizhen Liu ◽

Juyi Li ◽

Ling Li ◽

Jinjun Zhang ◽

...

Keyword(s):

Thyroid Hormone ◽

Liver Fibrosis ◽

Thyroid Function ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Normal Thyroid ◽

Hormone Levels ◽

Normal Thyroid Function ◽

Thyroid Hormone Levels

Abstract Background: The objective of this study is to retrospectively analyze the correlation between the thyroid hormones and nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients with normal thyroid function. Methods: Totally 586 T2DM patients with normal thyroid function participated in this research and were divided into T2DM without NAFLD (240 cases) group and T2DM with NAFLD (346 cases) group. The NAFLD fibrosis score (NFS) >0.676 was defined as progressive liver fibrosis and used to categorize the patients into T2DM without progressive liver fibrosis group (493 cases) and T2DM with progressive liver fibrosis group (93 cases). Results: The results indicated that the levels of free triiodothyronine (FT3) and total triiodomethylamine (TT3) were significantly higher while the free thyroxine (FT4) level was lower in T2DM with NAFLD group than that in T2DM2 without NAFLD group (p<0.05). The levels of FT3, FT4 and TT3 in patients with progressive liver fibrosis were significantly lower in patients with progressive liver fibrosis than that in patients without progressive liver fibrosis (p<0.05). Logistic regression analysis showed a negative relationship between FT4 level and NAFLD (p=0.026), between the levels of FT4,TT3 and total thyroxine (TT4) and the risk of progressive hepatic fibrosis (p=0.022, p=0.007,p=0.046).Conclusion: There is a certain correlation between thyroid hormone levels and NAFLD in T2DM patients, suggesting that the assessment of thyroid hormone levels in T2DM patients with normal thyroid function is of great significance in the prevention and treatment of NAFLD.

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