Prevalence of Chronic Kidney Disease in Morbidly Obese Japanese and the Impact of Bariatric Surgery on Disease Progression

2017 ◽  
Vol 28 (2) ◽  
pp. 489-496 ◽  
Author(s):  
Kotaro Wakamatsu ◽  
Yosuke Seki ◽  
Kazunori Kasama ◽  
Kohei Uno ◽  
Kenkichi Hashimoto ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Morbidly Obese ◽  
The Impact

Effects of bariatric surgery on the glomerular integrity of morbidly obese patients with chronic kidney disease (CKD)

2018 ◽  
Vol 14 (11) ◽  
pp. S2 ◽  
Author(s):  
David Romero Funes ◽  
David Gutierrez Blanco ◽  
Mauricio F Sarmiento-Cobos ◽  
Rama Ganga ◽  
Emanuele Lo Menzo ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Morbidly Obese ◽  
Obese Patients

scholarly journals Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 836
Author(s):  
Borja Lanzon ◽  
Marina Martin-Taboada ◽  
Victor Castro-Alves ◽  
Rocio Vila-Bedmar ◽  
Ignacio González de Pablos ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Bariatric Surgery ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Severe Obesity ◽  
Urine Analysis ◽  
Obese Patients ◽  
Lipid Species ◽  
Severely Obese ◽  
The Impact

Severe obesity is a major risk for chronic kidney disease (CKD). Early detection and careful monitoring of renal function are critical for the prevention of CKD during obesity, since biopsies are not performed in patients with CKD and diagnosis is dependent on the assessment of clinical parameters. To explore whether distinct lipid and metabolic signatures in obesity may signify early stages of pathogenesis toward CKD, liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-high resolution accurate mass-mass spectrometry (GC-HRAM-MS) analyses were performed in the serum and the urine of severely obese patients with and without CKD. Moreover, the impact of bariatric surgery (BS) in lipid and metabolic signature was also studied, through LC-MS and GC-HRAM-MS analyses in the serum and urine of patients with severe obesity and CKD before and after undergoing BS. Regarding patients with severe obesity and CKD compared to severely obese patients without CKD, serum lipidome analysis revealed significant differences in lipid signature. Furthermore, serum metabolomics profile revealed significant changes in specific amino acids, with isoleucine and tyrosine, increased in CKD patients compared with patients without CKD. LC-MS and GC-HRAM-MS analysis in serum of patients with severe obesity and CKD after BS showed downregulation of levels of triglycerides (TGs) and diglycerides (DGs) as well as a decrease in branched-chain amino acid (BCAA), lysine, threonine, proline, and serine. In addition, BS removed most of the correlations in CKD patients against biochemical parameters related to kidney dysfunction. Concerning urine analysis, hippuric acid, valine and glutamine were significantly decreased in urine from CKD patients after surgery. Interestingly, bariatric surgery did not restore all the lipid species, some of them decreased, hence drawing attention to them as potential targets for early diagnosis or therapeutic intervention. Results obtained in this study would justify the use of comprehensive mass spectrometry-based lipidomics to measure other lipids aside from conventional lipid profiles and to validate possible early markers of risk of CKD in patients with severe obesity.

scholarly journals Pre-dialysis chronic kidney disease progression over 4 years in the context of the Public Health System in Brazil: is ethnicity a factor?

HU Revista ◽  
2021 ◽  
Vol 47 ◽  
Author(s):  
Luciana dos Santos Tirapani Dalamura ◽  
Lucas Fernandes Suassuna ◽  
João Eduardo Cascelli Schelb Scalla Pereira ◽  
Rosália Maria Nunes Henriques Huaira ◽  
Neimar da Silva Fernandes ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Health System ◽  
Disease Progression ◽  
Laboratory Data ◽  
High Density Lipoproteins ◽  
Ckd Progression ◽  
Converting Enzyme Inhibitors ◽  
Black Patients ◽  
The Impact

Introduction: The prevalence of chronic kidney disease (CKD) significantly increased, and populations with high social vulnerability tend to have worse CKD progression. Objective: To evaluate the impact of ethnicity on the control of pre-dialytic CKD in a Brazilian Unified Health System interdisciplinary outpatient clinic. Material and Methods: Data of 1,992 CKD patients were retrospectively collected from August/2010 to December/2014. Patients referred by primary health care, >18 years, ≥ two consultations were included. Sociodemographic data were collected upon admission; clinical and laboratory data were obtained at each consultation. Patients were divided into groups according to skin colour (self-identified). A descriptive analysis was performed; variables were compared using ANOVA, chi-square or Mann-Whitney U tests. Variables associated with the delta of the estimated glomerular filtration rate (eGFR) were evaluated using linear regression, adjusting for confounding variables. Results: 25.1% were black, 34.4% brown, and 40.5% white. Approximately 51.2% had income ≤ two minimum wages, 84.8% had low level education, 14.0% were illiterate. Black patients were younger and had lower education level; they had higher systolic blood pressure, total cholesterol, high-density lipoproteins, intact parathyroid hormone; their haemoglobin and vitamin D were lower. The median annual eGFR loss was 0 (P25 −6.70, P75 +8.76), 36.5% had rapid eGFR loss (>5 ml/min/year). Only use of angiotensin-converting enzyme inhibitors and low proteinuria were determined as significant for the outcome (RR: 0.92, CI: 0.010–0.684, p=0.02; RR: 0.8, CI: 0.998-0.999, p=0.001). Conclusion: Ethnicity did not impact CKD progression, even though black patients presented clinical and sociodemographic characteristics associated with worse disease progression.

Sign in / Sign up

Export Citation Format

Share Document