Synthesis of poly(ethylene glycol)-SS-poly(ε-caprolactone)-SS-poly(ethylene glycol) triblock copolymers via end-group conjugation and self-assembly for reductively responsive drug delivery

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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Perfluoropolyether/poly(ethylene glycol) triblock copolymers with controllable self-assembly behaviour for highly efficient anti-bacterial materials

RSC Advances ◽

10.1039/c5ra08138f ◽

2015 ◽

Vol 5 (79) ◽

pp. 64170-64179 ◽

Cited By ~ 9

Author(s):

Jing Song ◽

Qun Ye ◽

Wang Ting Lee ◽

Xiaobai Wang ◽

Tao He ◽

...

Keyword(s):

Ethylene Glycol ◽

Self Assembly ◽

Click Reaction ◽

Triblock Copolymers ◽

Poly Ethylene Glycol ◽

Highly Efficient ◽

Poly Ethylene ◽

High Yields

A series of perfluoropolyether/poly(ethylene glycol) (PFPE/PEG) triblock copolymers PEG/PFPE/PEG (P1–P3) and PFPE/PEG/PFPE (P4–P5) were prepared via thiol–ene click reaction in high yields.

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SELF-ASSEMBLY MORPHOLOGIES AND ELECTRORHEOLOGICAL PROPERTIES OF POLYANILINE-POLY(ETHYLENE GLYCOL)-POLYANILINE TRIBLOCK COPOLYMERS

Electrorheological Fluids and Magnetorheological Suspensions ◽

10.1142/9789812771209_0045 ◽

2007 ◽

Author(s):

HUI-RU MA ◽

JIAN-GUO GUAN ◽

RUN-ZHANG YUAN

Keyword(s):

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Electrorheological Properties

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Biodegradable poly(ethylene glycol)–poly(ε-carprolactone) polymeric micelles with different tailored topological amphiphilies for doxorubicin (DOX) drug delivery

RSC Advances ◽

10.1039/c6ra06040d ◽

2016 ◽

Vol 6 (63) ◽

pp. 58160-58172 ◽

Cited By ~ 6

Author(s):

Y. Chen ◽

Y. X. Zhang ◽

Z. F. Wu ◽

X. Y. Peng ◽

T. Su ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Ethylene Glycol ◽

Self Assembly ◽

Polymeric Micelles ◽

The Self ◽

Molar Ratio ◽

Poly Ethylene Glycol ◽

Biodegradable Poly ◽

Poly Ethylene

The self-assembly and drug release of the three PEG–PCL copolymers with different topologies but identical molar ratio between PEG to PCL.

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Synthesis and Self-Assembly Study of Biodegradable Amphiphilic Triblock Copolymers with PEG Block

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.998-999.95 ◽

2014 ◽

Vol 998-999 ◽

pp. 95-98

Author(s):

Xu Du ◽

Qin Wang ◽

Chuan Dong Wang ◽

Yang Liu

Keyword(s):

Electron Microscopy ◽

Aqueous Solution ◽

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Poly Ethylene Glycol ◽

Chemical Structures ◽

Transmission Electron ◽

Spherical Micelles ◽

Poly Ethylene

Three biodegradable amphiphilic triblock copolymers: polylactide-poly (ethylene glycol)-polylactide (PLA-PEG-PLA), poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL) and poly (lactide-glycolide)-poly (ethylene glycol)-poly (lactide-glycolide) (PLGA-PEG-PLGA) were synthesized. Their chemical structures were characterized. In aqueous solution, their self-assembly and degradation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Spherical micelles were formed in aqueous solution via self-assembly of the amphiphilic triblock copolymers. After degradation, the PLA-PEG-PLA and PCL-PEG-PCL micelles became smaller and the PLGA-PEG-PLGA micelles change to vesicles, which should mainly attribute to their different degradation speed.

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SELF-ASSEMBLY MORPHOLOGIES AND ELECTRORHEOLOGICAL PROPERTIES OF POLYANILINE-POLY(ETHYLENE GLYCOL)- POLYANILINE TRIBLOCK COPOLYMERS

International Journal of Modern Physics B ◽

10.1142/s021797920704589x ◽

2007 ◽

Vol 21 (28n29) ◽

pp. 4961-4966

Author(s):

HUI-RU MA ◽

JIAN-GUO GUAN ◽

RUN-ZHANG YUAN

Keyword(s):

Ethylene Glycol ◽

Self Assembly ◽

Solubility Parameter ◽

Triblock Copolymers ◽

The Self ◽

Poly Ethylene Glycol ◽

Polarization Rate ◽

Poly Ethylene ◽

Electrorheological Properties

The self-assembly properties and ER effects of the Polyaniline-Poly(ethylene glycol)-Polyaniline (PAn-PEG-PAn) triblock copolymers were studied in this paper. The results indicate that with the increase of solubility parameter of the solvent, PAn-PEG-PAn copolymers form into different morphologies of spheriods, vesicles and rods. PAn-PEG-PAn copolymers with vesicles morphology show the highest polarization strength, while those with rods have the most rapid polarization rate. Among the PAn-PEG-PAn copolymers of different morphologies, the PAn-PEG-PAn copolymer vesicles show the strongest ER effect.

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Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.749.433 ◽

2015 ◽

Vol 749 ◽

pp. 433-436

Author(s):

Chih Kuang Chen ◽

Wen Jen Lin ◽

Guan You Chen ◽

Yu Te Lin ◽

Rong Siou Jhu ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Chain Length ◽

Self Assembly ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Poly Ethylene Glycol ◽

Anticancer Drug Delivery ◽

Material Chemistry ◽

Poly Ethylene

With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer drug delivery. In this study, a newly developed polymerization technique termed as “sequential ring-opening polymerization (SROP)“ was used to synthesize poly (ethylene glycol)-block-polylactide-block-polylactide (PEG-PLA-PLAs). Utilizing the features of SROP, well-controlled chain length of two different PLA blocks by using PEG as initiator can be achieved. Two types of PEG-PLA-PLAs, PEG-PLA11-PLA11 and PEG-PLA18-PLA18, were successfully synthesized and characterized. Having amphiphilic properties, PEG-PLA-PLAs were used to form micelles through self-assembly. The effects of PLA length on the resultant micelles were thoroughly investigated.

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