Synthesis and Self-Assembly Study of Biodegradable Amphiphilic Triblock Copolymers with PEG Block

2014 ◽  
Vol 998-999 ◽  
pp. 95-98
Author(s):  
Xu Du ◽  
Qin Wang ◽  
Chuan Dong Wang ◽  
Yang Liu
Keyword(s):  
Electron Microscopy ◽  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Chemical Structures ◽  
Transmission Electron ◽  
Spherical Micelles ◽  
Poly Ethylene

Three biodegradable amphiphilic triblock copolymers: polylactide-poly (ethylene glycol)-polylactide (PLA-PEG-PLA), poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL) and poly (lactide-glycolide)-poly (ethylene glycol)-poly (lactide-glycolide) (PLGA-PEG-PLGA) were synthesized. Their chemical structures were characterized. In aqueous solution, their self-assembly and degradation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Spherical micelles were formed in aqueous solution via self-assembly of the amphiphilic triblock copolymers. After degradation, the PLA-PEG-PLA and PCL-PEG-PCL micelles became smaller and the PLGA-PEG-PLGA micelles change to vesicles, which should mainly attribute to their different degradation speed.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

Perfluoropolyether/poly(ethylene glycol) triblock copolymers with controllable self-assembly behaviour for highly efficient anti-bacterial materials

RSC Advances ◽  
2015 ◽  
Vol 5 (79) ◽  
pp. 64170-64179 ◽  
Author(s):  
Jing Song ◽  
Qun Ye ◽  
Wang Ting Lee ◽  
Xiaobai Wang ◽  
Tao He ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Click Reaction ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Highly Efficient ◽  
Poly Ethylene ◽  
High Yields

A series of perfluoropolyether/poly(ethylene glycol) (PFPE/PEG) triblock copolymers PEG/PFPE/PEG (P1–P3) and PFPE/PEG/PFPE (P4–P5) were prepared via thiol–ene click reaction in high yields.

Thermogelation Properties of ABA Triblock Copolymers of Poly(Ethylene Glycol) (B) and Copolyacrylates of Oligo(Ethylene Glycol)s (A) in Aqueous Solution

2013 ◽  
Vol 11 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Ioana Negru ◽  
Mircea Teodorescu ◽  
Paul O. Stănescu ◽  
Constantin Drăghici ◽  
Anamaria Lungu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Copolymer Nanoparticles Prepared by Self-Assembly of Poly(ethylene glycol) and Poly-γ-Glutamic Acid and its Characteristics

2013 ◽  
Vol 662 ◽  
pp. 136-139
Author(s):  
Ge Yang ◽  
Ke Shuai Lu ◽  
Xue Yan Su
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Poly Ethylene Glycol ◽  
Polyelectrolyte Complexes ◽  
Self Assembling ◽  
Transmission Electron ◽  
Poly Ethylene

The paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and poly(ethylene glycol) (PEG). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic lightscattering and transmission electron microscopy.It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and PEG solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 30–270 nm. measured by TEM, and the average hydrodynamic diameters were between 130 and 300 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.

SELF-ASSEMBLY MORPHOLOGIES AND ELECTRORHEOLOGICAL PROPERTIES OF POLYANILINE-POLY(ETHYLENE GLYCOL)- POLYANILINE TRIBLOCK COPOLYMERS

2007 ◽  
Vol 21 (28n29) ◽  
pp. 4961-4966
Author(s):  
HUI-RU MA ◽  
JIAN-GUO GUAN ◽  
RUN-ZHANG YUAN
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Solubility Parameter ◽  
Triblock Copolymers ◽  
The Self ◽  
Poly Ethylene Glycol ◽  
Polarization Rate ◽  
Poly Ethylene ◽  
Electrorheological Properties

The self-assembly properties and ER effects of the Polyaniline-Poly(ethylene glycol)-Polyaniline (PAn-PEG-PAn) triblock copolymers were studied in this paper. The results indicate that with the increase of solubility parameter of the solvent, PAn-PEG-PAn copolymers form into different morphologies of spheriods, vesicles and rods. PAn-PEG-PAn copolymers with vesicles morphology show the highest polarization strength, while those with rods have the most rapid polarization rate. Among the PAn-PEG-PAn copolymers of different morphologies, the PAn-PEG-PAn copolymer vesicles show the strongest ER effect.

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