Study on the α-cyclodextrin/poly(ethylene glycol) self-assembly supramolecular nanoparticles for drug delivery

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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Synthesis of poly(ethylene glycol)-SS-poly(ε-caprolactone)-SS-poly(ethylene glycol) triblock copolymers via end-group conjugation and self-assembly for reductively responsive drug delivery

Frontiers of Materials Science ◽

10.1007/s11706-019-0475-y ◽

2019 ◽

Vol 13 (4) ◽

pp. 410-419

Author(s):

Junbo Li ◽

Junting Jiang ◽

Biyu Zhou ◽

Chaohuang Niu ◽

Wendi Wang ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

End Group

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Biodegradable poly(ethylene glycol)–poly(ε-carprolactone) polymeric micelles with different tailored topological amphiphilies for doxorubicin (DOX) drug delivery

RSC Advances ◽

10.1039/c6ra06040d ◽

2016 ◽

Vol 6 (63) ◽

pp. 58160-58172 ◽

Cited By ~ 6

Author(s):

Y. Chen ◽

Y. X. Zhang ◽

Z. F. Wu ◽

X. Y. Peng ◽

T. Su ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Ethylene Glycol ◽

Self Assembly ◽

Polymeric Micelles ◽

The Self ◽

Molar Ratio ◽

Poly Ethylene Glycol ◽

Biodegradable Poly ◽

Poly Ethylene

The self-assembly and drug release of the three PEG–PCL copolymers with different topologies but identical molar ratio between PEG to PCL.

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Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.749.433 ◽

2015 ◽

Vol 749 ◽

pp. 433-436

Author(s):

Chih Kuang Chen ◽

Wen Jen Lin ◽

Guan You Chen ◽

Yu Te Lin ◽

Rong Siou Jhu ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Chain Length ◽

Self Assembly ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Poly Ethylene Glycol ◽

Anticancer Drug Delivery ◽

Material Chemistry ◽

Poly Ethylene

With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer drug delivery. In this study, a newly developed polymerization technique termed as “sequential ring-opening polymerization (SROP)“ was used to synthesize poly (ethylene glycol)-block-polylactide-block-polylactide (PEG-PLA-PLAs). Utilizing the features of SROP, well-controlled chain length of two different PLA blocks by using PEG as initiator can be achieved. Two types of PEG-PLA-PLAs, PEG-PLA11-PLA11 and PEG-PLA18-PLA18, were successfully synthesized and characterized. Having amphiphilic properties, PEG-PLA-PLAs were used to form micelles through self-assembly. The effects of PLA length on the resultant micelles were thoroughly investigated.

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Effects of the molecular weight and the valency of guest-modified poly(ethylene glycol)s on the stability, size and dynamics of supramolecular nanoparticles

Journal of Materials Chemistry B ◽

10.1039/c5tb01111f ◽

2015 ◽

Vol 3 (34) ◽

pp. 6945-6952 ◽

Cited By ~ 10

Author(s):

Carmen Stoffelen ◽

Eugenio Staltari-Ferraro ◽

Jurriaan Huskens

Keyword(s):

Molecular Weight ◽

Ethylene Glycol ◽

Self Assembly ◽

The Self ◽

Pronounced Effect ◽

Poly Ethylene Glycol ◽

Size Stability ◽

Supramolecular Nanoparticles ◽

Poly Ethylene ◽

The Stability

The length and valency of PEG-based stopper molecules have a pronounced effect on the self-assembly, size, stability and dynamics of supramolecular nanoparticles.

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