Cinnamaldehyde targets TLR-4 and inflammatory mediators in acetic-acid induced ulcerative colitis model

Biologia ◽  
2021 ◽  
Author(s):  
Saeideh Momtaz ◽  
Maryam Navabakhsh ◽  
Negin Bakouee ◽  
Mustafa Dehnamaki ◽  
Mahban Rahimifard ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Inflammatory Mediators ◽  
Colitis Model

scholarly journals The new experimental ulcerative colitis model in rats induced by subserosal injection of acetic acid.

2001 ◽  
Vol 118 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Ryotaro KOJIMA ◽  
Shoichi HAMAMOTO ◽  
Masahiko MORIWAKI ◽  
Katsuharu IWADATE ◽  
Tatsuya OHWAKI
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Experimental Ulcerative Colitis ◽  
Colitis Model

Regulation of IL-6/STAT-3/Wnt axis by nifuroxazide dampens colon ulcer in acetic acid-induced ulcerative colitis model: Novel mechanistic insight

Life Sciences ◽  
2021 ◽  
Vol 276 ◽  
pp. 119433
Author(s):  
Fares E.M. Ali ◽  
Mohamed M. Elfiky ◽  
Walaa A. Fadda ◽  
Howaida S. Ali ◽  
Amany Refaat Mahmoud ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Mechanistic Insight ◽  
Colitis Model

Effect of escitalopram on an acetic acid‐induced ulcerative colitis model

2021 ◽  
Vol 48 (5) ◽  
pp. 782-790
Author(s):  
Negar Firouzabadi ◽  
Nahid Alimoradi ◽  
Mohammad Najafizadeh ◽  
Parvaneh Najafizadeh
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Colitis Model

scholarly journals Eluxadoline Loaded Solid Lipid Nanoparticles for Improved Colon Targeting in Rat Model of Ulcerative Colitis

2020 ◽  
Vol 13 (9) ◽  
pp. 255
Author(s):  
Md. Khalid Anwer ◽  
Mohammed Muqtader Ahmed ◽  
Mohammed F. Aldawsari ◽  
Saad Alshahrani ◽  
Farhat Fatima ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Zeta Potential ◽  
Solid Lipid Nanoparticles ◽  
In Vitro Release ◽  
Lipid Nanoparticles ◽  
Stability Studies ◽  
Solid Lipid ◽  
Vitro Release

The aim of the current study was to evaluate the therapeutics potential of eluxadoline (ELX) loaded solid lipid nanoparticles (SLNs) in ulcerative colitis. ELX loaded SLNs were prepared using three different lipids according to the solvent emulsification technique. The optimization of prepared SLNs (F1-F3) were carried out based on size, PDI, zeta potential, percent drug entrapment (%EE), and loading (%DL). The lipid (stearic acid) based SLNs (F2) was optimized with particle size (266.0 ± 6.4 nm), PDI (0.217 ± 0.04), zeta potential (31.2 ± 5.19 mV), EE (65.0 ± 4.8%), and DL (4.60 ± 0.8%). The optimized SLNs (F2) was further evaluated by DSC, FTIR, SEM, in vitro release, and stability studies, which confirmed the successful encapsulation of ELX in SLNs. The efficacy of optimized SLNs (F2) in comparison to the pure ELX drug was assessed in acetic acid induced colitis rat models. It was observed that the delivery of ELX by SLNs alleviated the induced acetic acid colitis significantly. Thus, ELX loaded SLNs delivery to the colon has a significant potential to be developed for the treatment of ulcerative colitis.

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