scholarly journals Whole Bone Mechanics and Bone Quality

2011 ◽  
Vol 469 (8) ◽  
pp. 2139-2149 ◽  
Author(s):  
Jacqueline H. Cole ◽  
Marjolein C. H. van der Meulen
Keyword(s):  
2012 ◽  
Vol 45 (2) ◽  
pp. 1013-1017 ◽  
Author(s):  
Paulo R. Fernandes ◽  
Helder C. Rodrigues ◽  
José M. Guedes ◽  
Pedro G. Coelho

Endocrinology ◽  
2010 ◽  
Vol 152 (2) ◽  
pp. 457-467 ◽  
Author(s):  
Kimberly A. Kyle ◽  
Thomas L. Willett ◽  
Laurie L. Baggio ◽  
Daniel J. Drucker ◽  
Marc D. Grynpas

Abstract Patients with type 2 diabetes mellitus have an increased risk of fracture that can be further exacerbated by thiazolidinediones. A new class of antidiabetic agents control glucose through reduction of dipeptidyl peptidase-4 (DPP-4) activity; however the importance of DPP-4 for the control of bone quality has not been extensively characterized. We compared the effects of the thiazolidinedione pioglitazone and the DPP-4 inhibitor sitagliptin on bone quality in high-fat diet (HFD)-fed wild-type mice. In complementary studies, we examined bone quality in Dpp4+/+ vs. Dpp4−/− mice. Pioglitazone produced yellow bones with greater bone marrow adiposity and significantly reduced vertebral bone mechanics in male, female, and ovariectomized (OVX) HFD fed female mice. Pioglitazone negatively affected vertebral volumetric bone mineral density, trabecular architecture, and mineral apposition rate in male mice. Sitagliptin treatment of HFD-fed wild-type mice significantly improved vertebral volumetric bone mineral density and trabecular architecture in female mice, but these improvements were lost in females after OVX. Genetic inactivation of Dpp4 did not produce a major bone phenotype in male and female Dpp4−/− mice; however, OVX Dpp4−/− mice exhibited significantly reduced femoral size and mechanics. These findings delineate the skeletal consequences of pharmacological and genetic reduction of DPP-4 activity and reveal significant differences in the effects of pioglitazone vs. sitagliptin vs. genetic Dpp4 inactivation on bone mechanics in mice.


Ob Gyn News ◽  
2005 ◽  
Vol 40 (10) ◽  
pp. 12
Author(s):  
KERRI WACHTER
Keyword(s):  

2013 ◽  
Author(s):  
Maurizio Feola ◽  
Cecilia Rao ◽  
Monica Celi ◽  
Elena Gasbarra ◽  
Umberto Tarantino

2013 ◽  
Author(s):  
Alberto Argentiero ◽  
Nadia Agnello ◽  
Cosimo Neglia ◽  
Giovanna Chitano ◽  
Rosa Alessandra Della ◽  
...  
Keyword(s):  

Author(s):  
Peter Jackuliak ◽  
Zdenko Killinger ◽  
Juraj Payer

2020 ◽  
Vol 46 (3) ◽  
pp. 182-189 ◽  
Author(s):  
Davide Farronato ◽  
Mattia Manfredini ◽  
Michele Stocchero ◽  
Mattia Caccia ◽  
Lorenzo Azzi ◽  
...  

The aim of this study was to evaluate the influence of bone quality, drilling technique, implant diameter, and implant length on insertion torque (IT) and resonance frequency analysis (RFA) of a prototype-tapered implant with knife-edge threads. The investigators hypothesized that IT would be affected by variations in bone quality and drilling protocol, whereas RFA would be less influenced by such variables. The investigators implemented an in vitro experiment in which a prototype implant was inserted with different testing conditions into rigid polyurethane foam blocks. The independent variables were: bone quality, drilling protocol, implant diameter, and implant length. Group A implants were inserted with a conventional drilling protocol, whereas Group B implants were inserted with an undersized drilling protocol. Values of IT and RFA were measured at implant installation. IT and RFA values were significantly correlated (Pearson correlation coefficient: 0.54). A multivariable analysis showed a strong model. Higher IT values were associated with drilling protocol B vs A (mean difference: 71.7 Ncm), implant length (3.6 Ncm increase per mm in length), and substrate density (0.199 Ncm increase per mg/cm3 in density). Higher RFA values were associated with drilling protocol B vs A (mean difference: 3.9), implant length (1.0 increase per mm in length), and substrate density (0.032 increase per mg/cm3 in density). Implant diameter was not associated with RFA or IT. Within the limitations of an in vitro study, the results of this study suggest that the studied implant can achieve good level of primary stability in terms of IT and RFA. A strong correlation was found between values of IT and RFA. Both parameters are influenced by the drilling protocol, implant length, and substrate density. Further studies are required to investigate the clinical response in primary stability and marginal bone response.


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