Multiscale Modelling on Bone Mechanics – Application to Tissue Engineering and Bone Quality Analysis

2012 ◽  
Vol 45 (2) ◽  
pp. 1013-1017 ◽  
Author(s):  
Paulo R. Fernandes ◽  
Helder C. Rodrigues ◽  
José M. Guedes ◽  
Pedro G. Coelho
Keyword(s):  
Tissue Engineering ◽  
Bone Quality ◽  
Multiscale Modelling ◽  
Quality Analysis ◽  
Bone Mechanics

Dental Cone Beam Computed Tomography for Trabecular Bone Quality Analysis in Maxilla and Mandible

2021 ◽  
pp. 542-564
Author(s):  
T. Christy Bobby ◽  
Shwetha V. ◽  
Vijaya Madhavi
Keyword(s):  
Trabecular Bone ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Quality Analysis ◽  
Trabecular Bone Microarchitecture ◽  
The Stability ◽  
Maxilla And Mandible ◽  
Trabecular Bone Quality ◽  
Implant Treatment

The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.

scholarly journals Differential Effects of PPAR-γ Activation versus Chemical or Genetic Reduction of DPP-4 Activity on Bone Quality in Mice

Endocrinology ◽  
2010 ◽  
Vol 152 (2) ◽  
pp. 457-467 ◽  
Author(s):  
Kimberly A. Kyle ◽  
Thomas L. Willett ◽  
Laurie L. Baggio ◽  
Daniel J. Drucker ◽  
Marc D. Grynpas
Keyword(s):  
Bone Mineral Density ◽  
Bone Quality ◽  
Bone Mineral ◽  
Volumetric Bone Mineral Density ◽  
Trabecular Architecture ◽  
Bone Mechanics ◽  
Wild Type ◽  
Mineral Density ◽  
Female Mice ◽  
Increased Risk

Abstract Patients with type 2 diabetes mellitus have an increased risk of fracture that can be further exacerbated by thiazolidinediones. A new class of antidiabetic agents control glucose through reduction of dipeptidyl peptidase-4 (DPP-4) activity; however the importance of DPP-4 for the control of bone quality has not been extensively characterized. We compared the effects of the thiazolidinedione pioglitazone and the DPP-4 inhibitor sitagliptin on bone quality in high-fat diet (HFD)-fed wild-type mice. In complementary studies, we examined bone quality in Dpp4+/+ vs. Dpp4−/− mice. Pioglitazone produced yellow bones with greater bone marrow adiposity and significantly reduced vertebral bone mechanics in male, female, and ovariectomized (OVX) HFD fed female mice. Pioglitazone negatively affected vertebral volumetric bone mineral density, trabecular architecture, and mineral apposition rate in male mice. Sitagliptin treatment of HFD-fed wild-type mice significantly improved vertebral volumetric bone mineral density and trabecular architecture in female mice, but these improvements were lost in females after OVX. Genetic inactivation of Dpp4 did not produce a major bone phenotype in male and female Dpp4−/− mice; however, OVX Dpp4−/− mice exhibited significantly reduced femoral size and mechanics. These findings delineate the skeletal consequences of pharmacological and genetic reduction of DPP-4 activity and reveal significant differences in the effects of pioglitazone vs. sitagliptin vs. genetic Dpp4 inactivation on bone mechanics in mice.

Bone quality analysis using X-ray microtomography and microfluorescence

2012 ◽  
Vol 70 (7) ◽  
pp. 1272-1276 ◽  
Author(s):  
E. Sales ◽  
I. Lima ◽  
J.T. de Assis ◽  
W. Gómez ◽  
W.C.A. Pereira ◽  
...  
Keyword(s):  
Bone Quality ◽  
Quality Analysis ◽  
X Ray

Dental Cone Beam Computed Tomography for Trabecular Bone Quality Analysis in Maxilla and Mandible

2019 ◽  
pp. 151-177
Author(s):  
T. Christy Bobby ◽  
Shwetha V. ◽  
Vijaya Madhavi
Keyword(s):  
Trabecular Bone ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Quality Analysis ◽  
Trabecular Bone Microarchitecture ◽  
The Stability ◽  
Maxilla And Mandible ◽  
Trabecular Bone Quality ◽  
Implant Treatment

The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.

scholarly journals Whole Bone Mechanics and Bone Quality

2011 ◽  
Vol 469 (8) ◽  
pp. 2139-2149 ◽  
Author(s):  
Jacqueline H. Cole ◽  
Marjolein C. H. van der Meulen
Keyword(s):  
Bone Quality ◽  
Bone Mechanics

scholarly journals Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Gustavo Davi Rabelo ◽  
Annika vom Scheidt ◽  
Felix Klebig ◽  
Haniyeh Hemmatian ◽  
Mustafa Citak ◽  
...  
Keyword(s):  
Bone Quality ◽  
Knee Joints ◽  
Quality Analysis ◽  
Osteoarthritic Knee

scholarly journals Micro- and nanostructural characteristics of rat masseter muscle entheses -Characteristics of masseter muscle entheses-

2019 ◽  
Author(s):  
Keitaro Arakawa ◽  
Satoru Matsunaga ◽  
Kunihiko Nojima ◽  
Takayoshi Nakano ◽  
Shinichi Abe ◽  
...  
Keyword(s):  
Bone Quality ◽  
Masseter Muscle ◽  
Bone Structure ◽  
Applied Pressure ◽  
Third Molar ◽  
Morphological Characteristics ◽  
Masticatory Muscles ◽  
Quality Analysis ◽  
The Third ◽  
Molar Region

AbstractThe entheses of the masticatory muscles differ slightly from those of the trunk and limb muscles. However, the bones of the skull are subject to various functional pressures, including masticatory force, resulting in a complex relationship between bone structure and muscle function that remains to be fully elucidated. The present study aimed to clarify aspects of masseter muscle-tendon-bone morphological characteristics and local load environment through quantitative analysis of biological apatite (BAp) crystallite alignment and collagen fiber orientation together with histological examination of the entheses.Result of histological observation, the present findings show that, in the entheses of the masseter muscle in the first molar region, tendon attaches to bone via unmineralized fibrocartilage, while some tendon collagen fibers insert directly into the bone, running parallel to the muscle fibers. Furthermore, BAp crystallites in the same region show uniaxial preferential alignment at an angle that matches the insertion angle of the tendon fibers. Conversely, in the entheses of the masseter muscle in the third molar region, the tendon attaches to the bone via a layer of thickened periosteum and chondrocytes. As in the first molar region, the results of bone quality analysis in the third molar region showed BAp crystallite alignment parallel to the orientation of the tendon fibers. This indicates that the local mechanical environment generates differences in enthesis morphology.The present study showed a greater degree of uniaxial BAp crystallite alignment in entheses with direct insertion rather than indirect tendon-bone attachment and the direction of alignment was parallel to the orientation of tendon fibers. These findings suggest that functional pressure from the masseter muscle greatly affects bone quality as well as the morphological characteristics of the enthesis, specifically causing micro- and nanostructural anisotropy in the direction of resistance to the applied pressure.

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