Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population

2015 ◽  
Vol 167 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Guanchao Zheng ◽  
Lijun Wang ◽  
Zhizhun Guo ◽  
Lingbin Sun ◽  
Lingling Wang ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Polycystic Ovary Syndrome ◽  
Trace Element ◽  
Chinese Population ◽  
Polycystic Ovary ◽  
Reproductive Hormone ◽  
Ovary Syndrome ◽  
Hormone Levels ◽  
Element Concentrations

Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

2016 ◽  
Vol 175 (2) ◽  
pp. 254-262 ◽  
Author(s):  
Poli Mara Spritzer ◽  
Sheila Bünecker Lecke ◽  
Vitor Costa Fabris ◽  
Patrícia Klarmann Ziegelmann ◽  
Lívio Amaral
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Trace Element ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Ovary Syndrome ◽  
Element Concentrations

scholarly journals Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population

2015 ◽  
Vol 172 (3) ◽  
pp. 227-233 ◽  
Author(s):  
Rong Ju ◽  
Wei Wu ◽  
Juan Fei ◽  
Yufeng Qin ◽  
Qiuqin Tang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Chinese Population ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Control Group ◽  
Model Assessment ◽  
Nucleotide Polymorphisms ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
High Level

ObjectiveTo assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) and HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population.DesignA case–control study was conducted to investigate the relation between HSD17B5 and HSD17B6 polymorphisms and PCOS.MethodsIn this study, 335 patients with PCOS and 354 controls were recruited. The genotypes of HSD17B5 (rs1937845 and rs12529) and HSD17B6 (rs898611) were detected by the TaqMan method.Results and conclusionsWe found that the genotypic frequencies of the rs1937845 polymorphism were different in subjects with PCOS compared with control, with the CT genotype being more commonly found in patients with PCOS than in controls (P=0.005). We observed a significantly 1.74-fold higher risk of CT genotype in the polymorphism rs1937845 in women with PCOS vs the control group (adjusted odds ratio (OR), 1.74; 95% CI=1.19–2.54; P=0.005). A similar, significant 1.47-fold higher risk (adjusted OR, 1.47; 95% CI=1.07–2.03; P=0.018) was demonstrated for T allele of polymorphism rs1937845 associated with PCOS. In patients with PCOS, the rs12529 (G>C) and rs1937845 (C>T) polymorphisms were strongly associated with the high level of testosterone. The TT carriers of polymorphism rs1937845 had a significantly increased homeostatic model assessment-B% (HOMA-B%) (P=0.045) and that might be associated with the high risk of insulin resistance. However, no significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls. Additionally, the two polymorphisms of HSD17B5 are associated with hyperandrogenemia in patients with PCOS. In conclusion, our findings showed a significant statistical association between HSD17B5 rs1937845 and PCOS risk in Chinese women. The CT genotype and T allele frequency are influenced significantly to a higher extent in patients with PCOS than controls. Further studies are needed to confirm the results and find out the exact molecular mechanism of the polymorphism on the risk of hyperandrogenemia and PCOS.

scholarly journals Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome

2015 ◽  
Vol 54 (6) ◽  
pp. 686-692 ◽  
Author(s):  
Jehn-Hsiahn Yang ◽  
Chia-Hung Chou ◽  
Wei-Shiung Yang ◽  
Hong-Nerng Ho ◽  
Yu-Shih Yang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Ovarian Volume ◽  
Negatively Associated ◽  
Hormone Levels ◽  
Iron Stores

Polycystic ovary syndrome: relationship between insulin sensitivity, sex hormone levels and ovarian stromal blood flow

2001 ◽  
Vol 15 (2) ◽  
pp. 142-149 ◽  
Author(s):  
G. Loverro ◽  
M. Vicino ◽  
F. Lorusso ◽  
A. Vimercati ◽  
P. Greco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Ovary Syndrome ◽  
Hormone Levels
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