Association of Genetic Variations in NRF2, NQO1, HMOX1, and MT with Severity of Coronary Artery Disease and Related Risk Factors

2019 ◽  
Vol 20 (2) ◽  
pp. 176-189 ◽  
Author(s):  
Ingkarat Sarutipaiboon ◽  
Nongnuch Settasatian ◽  
Nantarat Komanasin ◽  
Upa Kukongwiriyapan ◽  
Kittisak Sawanyawisuth ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variations ◽  
Related Risk ◽  
Artery Disease

scholarly journals Lifestyle related risk factors of coronary artery disease patients in Nepal

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
P Gaudel ◽  
M Kaunonen ◽  
S Neupane ◽  
K Joronen ◽  
A M Koivisto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Categorical Variables ◽  
Dietary Habit ◽  
Total Study Population ◽  
Related Risk ◽  
Study Population ◽  
Artery Disease

Abstract Background Coronary Artery Disease (CAD) is a leading cause of morbidity and mortality and serious health problem worldwide. It is important to observe lifestyle related risk factors in patients with CAD for effective planning and implementation of secondary prevention strategies. The aim of this study is to describe the prevalence of lifestyle related risk factor habits among the patients with CAD. Methods A cross-sectional study was conducted among CAD patients in a tertiary care national heart center in Kathmandu, Nepal. Six lifestyle related factors (dietary habit, smoking, alcohol consumption, stress, physical activity and adherence to medication) and Body Mass Index were used as the risk factors of CAD in this study. Individual face-to-face structured interview was conducted using culturally validated standard instruments. The descriptive characteristics were presented as frequencies and percentages for categorical variables and as mean ± standard deviation (SD) or median and interquartile range (IQR) otherwise. Results In total study population, the mean age of the patients was 59.9 years and 76% were male. Patients having any three risk factors out of seven were the most common (36%) followed by two risk factors (25%) and four risk factors (22%). About 32% of study population were current smokers, whereas 29% were former smokers. Likewise, 31% of the total were physically inactive. Majority of the patients 95% had perceived moderate stress. Conclusions The prevalence of lifestyle related risk factors is high among CAD patients in study population. Combination of any three lifestyle related risk factors were the most common among patients. Therefore, studies focusing on lifestyle risk factor modification intervention on particular groups is recommended. Key messages Need to improve awareness about lifestyle related risk factors among CAD patients. Highlight the importance of lifestyle counselling.

Lifestyle‐related risk factors among patients with coronary artery disease in Nepal

2019 ◽  
Vol 34 (3) ◽  
pp. 782-791
Author(s):  
Pramila Gaudel ◽  
Marja Kaunonen ◽  
Subas Neupane ◽  
Katja Joronen ◽  
Anna‐Maija Koivisto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Related Risk ◽  
Artery Disease

Changes in knowledge, attitudes and practices among coronary artery disease patients

2012 ◽  
Vol 42 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Richa Chaturvedi ◽  
Nimali Singh
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Life Style ◽  
Close Association ◽  
Content Type ◽  
Attitudes And Practices ◽  
Related Risk ◽  
Artery Disease ◽  
Knowledge Attitudes And Practices

PurposeThe purpose of this paper is to analyze changes in knowledge, attitudes and practices (KAP) regarding diet and life style related risk factors among male and female coronary artery disease (CAD) patients (30‐60 yrs), in Jaipur city.Design/methodology/approachAll willing patients under medical supervision for CAD were included. A detailed pre‐tested and standardized interview schedule was used to elicit required information. In total, 100 subjects were assessed for KAP. Retrospective data were recorded for the information on KAP prior to the incidence of the disease.FindingsThe major findings revealed that there was a significant change in knowledge, attitudes and practices before and after the incidence of CAD. Knowledge and attitudes were found to have a strong association. Close association was statistically established between knowledge and smoking practice for male subjects and between attitudes and weight loss for female patients. No association could be established for other attributes.Originality/valueThe study explores the effect of CAD on the knowledge, attitude and practices of the patients regarding diet and life style related risk factors. It also observes and compares the data for prior to the frank expression of the disease and after the disease.

Abstract 2319: Genetic Variations Of Mrf-2/Arid5b Confer Risk Of Coronary Artery Disease And Diabetes Mellitus In The Japanese Population

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Guoqin Wang ◽  
Masafumi Watanabe ◽  
Yasushi Imai ◽  
Kazuo Hara ◽  
Ichiro Manabe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variations ◽  
Coronary Risk Factors ◽  
Control Subjects ◽  
Individual Snps ◽  
Disease Associations ◽  
Artery Disease

Mrf-2/Arid5b, a member of AT-rich interaction domain family of transcription factors, is highly expressed in the cardiovascular system and is believed to play essential roles in the phenotypic change through its regulation of smooth muscle cell differentiation. In addition, recent studies on gene-engineered mice suggested that this transcriptional factor is involved in obesity and adipogenesis, which are critical aspects of metabolic syndrome and diabetes mellitus. Thus, we hypothesized that genetic variations of the Mrf-2 gene may be associated with susceptibility to coronary artery disease (CAD) and diabetes mellitus (DM). To examine the association between Mrf-2 polymorphisms and CAD, we investigated 17 common SNPs of Mrf-2 in 475 CAD subjects and 310 control subjects. Four nearby SNPs (rs2893880, rs10740055, rs7087507 and rs10761600) showed almost complete linkage disequilibrium, and disease associations were revealed not only for individual SNPs ( P =0.0002, rs2893880; P =0.0067, rs7087507, respectively) but also for their haplotype combination ( P =0.04, G-C-G-A (rs2893880-rs10740055-rs7087507-rs10761600)). Furthermore, these positive disease associations still existed after logistic regression analysis was performed to eliminate confounding conventional coronary risk factors. Subsequent analysis revealed that the aforementioned SNPs also statistically conferred risk of DM. To confirm these findings, we recruited another 500 DM subjects and 500 control subjects, and assessed the same haplotype block for their disease associations. Consistent significant associations were observed ( P =0.0238, rs2893880; P =0.0014, rs10740055; P =0.0067, rs7087507; P =0.0022, rs10761600; P =0.0031 and P =0.04, C-A-A-T and G-C-G-A (rs2893880-rs10740055-rs7087507- rs10761600), respectively). Moreover, the disease-associated genotypes were also revealed to be correlated with the level of serum adiponectin, which is known as an anti-diabetic adipocytokine. . In conclusion, our study implicates genetic variations of Mrf-2 as previously unknown genetic risk factors for CAD and DM. We believe that the associations of Mrf-2 with CAD may be mediated at least partly via its associations with DM.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 442-P
Author(s):  
KAZUYA FUJIHARA ◽  
YASUHIRO MATSUBAYASHI ◽  
MASARU KITAZAWA ◽  
MASAHIKO YAMAMOTO ◽  
TAEKO OSAWA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Disease
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