Short Peptides Protect Oral Stem Cells from Ageing

2019 ◽  
Vol 16 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Bruna Sinjari ◽  
Francesca Diomede ◽  
Vladimir Khavinson ◽  
Ekaterina Mironova ◽  
Natalia Linkova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Short Peptides ◽  
Oral Stem Cells

scholarly journals Mechanisms Involved in Apice Closure of Pulpless Teeth – Literature Review

2021 ◽  
Vol 15 (1) ◽  
pp. 127-136
Author(s):  
Alexandrino Pereira dos Santos Neto ◽  
Sandra Maria Alves Sayão Maia ◽  
Jair Carneiro Leão ◽  
Iliana Lins Quidute ◽  
Carolina dos Santos Guimarães ◽  
...  
Keyword(s):  
Stem Cells ◽  
Literature Review ◽  
Blood Supply ◽  
Root Formation ◽  
Adequate Blood Supply ◽  
Revascularization Therapy ◽  
Oral Stem Cells ◽  
Pulp Revascularization ◽  
Professional Intervention

Background: Unfinished root formation has always offered challenges in endodontics due to technical difficulties and weakened teeth resistance during the lifetime of an individual. Pulp revascularization therapy appeared as a solution for apical closure and root maturation. The existence of oral stem cells involved in the process associated with traditional resident cells requires adequate blood supply given by induced controlled injury deliberately accomplished into the periapical zone. Objective: The aim of this work was to research, through literature review, the main mechanisms involved in the process of apical closure through the technique of pulp revascularization. Conclusion: Apice closure in pulpless teeth seems to happen as a result of professional intervention and biological activity. The success rate depends on the role of traditional local immune cells and stem cells associated with adequate blood supply to finish root formation.

Endothelial committed oral stem cells as modelling in the relationship between periodontal and cardiovascular disease

2018 ◽  
Vol 233 (10) ◽  
pp. 6734-6747 ◽  
Author(s):  
Jacopo Pizzicannella ◽  
Francesca Diomede ◽  
Ilaria Merciaro ◽  
Sergio Caputi ◽  
Armando Tartaro ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Stem Cells ◽  
Oral Stem Cells ◽  
The Relationship

Short Peptides: On the Trail of Future Stem Cell-Based Regenerative Therapies

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Joanna Bojarska ◽  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
World Literature ◽  
Human Life ◽  
Biological Information ◽  
Short Peptides ◽  
Protective Effects ◽  
Promising Tool ◽  
Low Efficiency

Stem cells therapy is a great hope for untreatable diseases, transplantology and cosmetology. What is more, with regenerative benefits of stem cells, prolongation of human life is real. Nevertheless, stem cell-based therapeutical defects, such as low efficiency of differentiation or poor immune compatibility, cannot be overlooked. Short peptides, due to their unique features, play an important supporting role in culture medium to stimulate diverse activities of stem cells and provide a new glimpse into future regenerative biomedicine. These simple biomolecules, constituents of proteins, have relevance in the transmission of biological information, can penetrate the cell membrane or activate signalling pathways. They have immunomodulatory, gero-, neuro-, vaso- and skin-protective effects. They enhance proliferation and differentiation of stem cells. Utilizing of short peptides can be helpful in guiding stem cell fate, by mimicking native tissues, which leads to optimization of stem cell-based treatment. They are also important modifiers of scaffolds and modulators of biomaterials in relation to stem cells engineering. This mini review is a summary of the survey of the newest scientific findings, scattered across the world literature, focusing on short peptides as promising tool in seeking safe and effective stem cell-based therapeutical code.

Short Peptides: On the Trail of Future Stem Cell-Based Regenerative Therapies

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Joanna Bojarska ◽  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
World Literature ◽  
Human Life ◽  
Biological Information ◽  
Short Peptides ◽  
Protective Effects ◽  
Promising Tool ◽  
Low Efficiency

Stem cells therapy is a great hope for untreatable diseases, transplantology and cosmetology. What is more, with regenerative benefits of stem cells, prolongation of human life is real. Nevertheless, stem cell-based therapeutical defects, such as low efficiency of differentiation or poor immune compatibility, cannot be overlooked. Short peptides, due to their unique features, play an important supporting role in culture medium to stimulate diverse activities of stem cells and provide a new glimpse into future regenerative biomedicine. These simple biomolecules, constituents of proteins, have relevance in the transmission of biological information, can penetrate the cell membrane or activate signalling pathways. They have immunomodulatory, gero-, neuro-, vaso- and skin-protective effects. They enhance proliferation and differentiation of stem cells. Utilizing of short peptides can be helpful in guiding stem cell fate, by mimicking native tissues, which leads to optimization of stem cell-based treatment. They are also important modifiers of scaffolds and modulators of biomaterials in relation to stem cells engineering. This mini review is a summary of the survey of the newest scientific findings, scattered across the world literature, focusing on short peptides as promising tool in seeking safe and effective stem cell-based therapeutical code.

An Overview of Protocols for the Neural Induction of Dental and Oral Stem Cells In Vitro

2016 ◽  
Vol 22 (3) ◽  
pp. 220-250 ◽  
Author(s):  
Boon Chin Heng ◽  
Lee Wei Lim ◽  
Wutian Wu ◽  
Chengfei Zhang
Keyword(s):  
Stem Cells ◽  
Neural Induction ◽  
Oral Stem Cells

scholarly journals Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Ihsène Taïhi ◽  
Ali Nassif ◽  
Juliane Isaac ◽  
Benjamin Philippe Fournier ◽  
François Ferré
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Neural Crest ◽  
Cartilage Repair ◽  
Adult Stem Cells ◽  
Articular Chondrocytes ◽  
Cartilage Damage ◽  
Arthroscopic Surgery ◽  
Human Cartilage ◽  
Oral Stem Cells

A large array of therapeutic procedures is available to treat cartilage disorders caused by trauma or inflammatory disease. Most are invasive and may result in treatment failure or development of osteoarthritis due to extensive cartilage damage from repeated surgery. Despite encouraging results of early cell therapy trials that used chondrocytes collected during arthroscopic surgery, these approaches have serious disadvantages, including morbidity associated with cell harvesting and low predictive clinical outcomes. To overcome these limitations, adult stem cells derived from bone marrow and subsequently from other tissues are now considered as preferred sources of cells for cartilage regeneration. Moreover, with new evidence showing that the choice of cell source is one of the most important factors for successful cell therapy, there is growing interest in neural crest-derived cells in both the research and clinical communities. Neural crest-derived cells such as nasal chondrocytes and oral stem cells that exhibit chondrocyte-like properties seem particularly promising in cartilage repair. Here, we review the types of cells currently available for cartilage cell therapy, including articular chondrocytes and various mesenchymal stem cells, and then highlight recent developments in the use of neural crest-derived chondrocytes and oral stem cells for repair of cartilage lesions.

scholarly journals Role of ascorbic acid in the regulation of epigenetic processes induced by Porphyromonas gingivalis in endothelial-committed oral stem cells

2021 ◽  
Author(s):  
Jacopo Pizzicannella ◽  
Guya Diletta Marconi ◽  
Simone Guarnieri ◽  
Luigia Fonticoli ◽  
Ylenia Della Rocca ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ascorbic Acid ◽  
Periodontal Disease ◽  
Porphyromonas Gingivalis ◽  
Dna Methyltransferase ◽  
Intracellular Localization ◽  
In Vitro Study ◽  
Worldwide Population ◽  
Oral Stem Cells

AbstractPeriodontitis is a common inflammatory disease that affects the teeth-supporting tissue and causes bone and tooth loss. Moreover, in a worldwide population, periodontal disease is often associated with cardiovascular diseases. Emerging studies have reported that one of the major pathogens related to periodontitis is Porphyromonas gingivalis (P. gingivalis), which triggers the inflammatory intracellular cascade. Here, we hypothesized a possible protective effect of ascorbic acid (AA) in the restoration of the physiological molecular pathway after exposure to lipopolysaccharide derived from P. gingivalis (LPS-G). In particular, human gingiva-derived mesenchymal stem cells (hGMSCs) and endothelial-differentiated hGMSCs (e-hGMSCs) exposed to LPS-G showed upregulation of p300 and downregulation of DNA methyltransferase 1 (DNMT1), proteins associated with DNA methylation and histone acetylation. The co-treatment of AA and LPS-G showed a physiological expression of p300 and DNMT1 in hGMSCs and e-hGMSCs. Moreover, the inflammatory process triggered by LPS-G was demonstrated by evaluation of reactive oxygen species (ROS) and their intracellular localization. AA exposure re-established the physiological ROS levels. Despite the limitations of in vitro study, these findings collectively expand our knowledge regarding the molecular pathways involved in periodontal disease, and suggest the involvement of epigenetic modifications in the development of periodontitis.

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