Increased thyroid cancer incidence in a basaltic volcanic area is associated with non-anthropogenic pollution and biocontamination

Endocrine ◽  
2015 ◽  
Vol 53 (2) ◽  
pp. 471-479 ◽  
Author(s):  
Pasqualino Malandrino ◽  
Marco Russo ◽  
Anna Ronchi ◽  
Claudio Minoia ◽  
Daniela Cataldo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Incidence ◽  
Anthropogenic Pollution ◽  
Volcanic Area ◽  
Thyroid Cancer Incidence

scholarly journals Increased Thyroid Cancer Incidence in Volcanic Areas: A Role of Increased Heavy Metals in the Environment?

2020 ◽  
Vol 21 (10) ◽  
pp. 3425 ◽  
Author(s):  
Pasqualino Malandrino ◽  
Marco Russo ◽  
Fiorenza Gianì ◽  
Gabriella Pellegriti ◽  
Paolo Vigneri ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Thyroid Cancer ◽  
Cancer Incidence ◽  
Biological Effects ◽  
Anthropogenic Pollution ◽  
Volcanic Area ◽  
Carcinogenic Effect ◽  
Metal Levels ◽  
Intracellular Binding ◽  
Thyroid Cancer Incidence

Thyroid cancer incidence is significantly increased in volcanic areas, where relevant non-anthropogenic pollution with heavy metals is present in the environment. This review will discuss whether chronic lifelong exposure to slightly increased levels of metals can contribute to the increase in thyroid cancer in the residents of a volcanic area. The influence of metals on living cells depends on the physicochemical properties of the metals and their interaction with the target cell metallostasis network, which includes transporters, intracellular binding proteins, and metal-responsive elements. Very little is known about the carcinogenic potential of slightly increased metal levels on the thyroid, which might be more sensitive to mutagenic damage because of its unique biology related to iodine, which is a very reactive and strongly oxidizing agent. Different mechanisms could explain the specific carcinogenic effect of borderline/high environmental levels of metals on the thyroid, including (a) hormesis, the nonlinear response to chemicals causing important biological effects at low concentrations; (b) metal accumulation in the thyroid relative to other tissues; and (c) the specific effects of a mixture of different metals. Recent evidence related to all of these mechanisms is now available, and the data are compatible with a cause–effect relationship between increased metal levels in the environment and an increase in thyroid cancer incidence.

scholarly journals Re: Papillary Thyroid Cancer Incidence in the Volcanic Area of Sicily

2010 ◽  
Vol 102 (12) ◽  
pp. 914-915 ◽  
Author(s):  
Luigino Dal Maso ◽  
Silvia Franceschi ◽  
Mauro Lise ◽  
Mario Fusco ◽  
Rosario Tumino ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Incidence ◽  
Volcanic Area ◽  
Papillary Thyroid ◽  
Thyroid Cancer Incidence

Papillary Thyroid Cancer Incidence in the Volcanic Area of Sicily

2009 ◽  
Vol 101 (22) ◽  
pp. 1575-1583 ◽  
Author(s):  
Gabriella Pellegriti ◽  
Florent De Vathaire ◽  
Claudia Scollo ◽  
Marco Attard ◽  
Carla Giordano ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Incidence ◽  
Volcanic Area ◽  
Papillary Thyroid ◽  
Thyroid Cancer Incidence
Sign in / Sign up

Export Citation Format

Share Document