Locally produced estrogen through aromatization might enhance tissue expression of pituitary tumor transforming gene and fibroblast growth factor 2 in growth hormone-secreting adenomas

Endocrine ◽  
2015 ◽  
Vol 52 (3) ◽  
pp. 632-640 ◽  
Author(s):  
Hande Mefkure Ozkaya ◽  
Nil Comunoglu ◽  
Fatma Ela Keskin ◽  
Buge Oz ◽  
Ozlem Asmaz Haliloglu ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Pituitary Tumor ◽  
Tissue Expression ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Growth Hormone Secreting Adenomas

scholarly journals Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor, and growth hormone

2000 ◽  
Vol 279 (2) ◽  
pp. R548-R553 ◽  
Author(s):  
Alon Eliakim ◽  
Youngman Oh ◽  
Dan Michael Cooper
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Insulin Like Growth Factor ◽  
Fibroblast Growth ◽  
Wrist Flexion ◽  
Igf I ◽  
Muscle Groups ◽  
Igfbp 3

Anabolic effects of exercise are mediated, in part, by fibroblast growth factor-2 (FGF-2), insulin-like growth factor-I (IGF-I), and growth hormone (GH). To identify local vs. systemic modification of these mediators, 10 male subjects performed 10 min of unilateral wrist-flexion exercise. Blood was sampled from catheters placed in basilic veins of both arms. Lactate was significantly increased only in the exercising arm. FGF-2 decreased dramatically ( P < 0.01) in both the resting (from 1.49 ± 0.32 to nadir at 0.11 ± 0.11 pg/ml) and exercising arm (1.80 ± 0.60 to 0.29 ± 0.14 pg/ml). Small but significant increases were found in both the resting and exercising arm for IGF-I and IGF binding protein-3 (IGFBP-3). GH was elevated in blood sampled from both the resting (from 1.04 ± 0.68 to a peak of 2.57 ± 0.53 ng/ml) and exercising arm (1.04 ± 0.66 to 2.43 ± 0.42 ng/ml, P < 0.05). Unilateral wrist exercise was not sufficiently intense to increase circulating lactate or heart rate, but it led to systemic changes in GH, IGF-I, IGFBP-3, and FGF-2. Low-intensity exercise involving small muscle groups can influence the circulating levels of growth factors.

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