scholarly journals Acromegaly disease activity according to ACRODAT®, a cross-sectional study in Spain: ACROVAL study

Endocrine ◽  
2021 ◽  
Author(s):  
Mónica Marazuela ◽  
Concepción Blanco ◽  
Ignacio Bernabeu ◽  
Edelmiro Menendez ◽  
Rocío Villar ◽  
...  
Keyword(s):  
Disease Activity ◽  
Clinical Evaluation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mild Disease ◽  
Clinical Action ◽  
The Relationship

Abstract Objectives To evaluate disease activity status using the Acromegaly Disease Activity Tool (ACRODAT®) in a cohort of Spanish acromegaly patients, to assess the relationship between the level of disease activity according to both ACRODAT® and the physicians’ clinical evaluation, and to study the potential discrepancies in the perception of symptoms between physicians and patients. Design Multicenter, observational, descriptive and cross-sectional study. Methods Disease activity was assessed in adult patients with acromegaly under pharmacological treatment during at least 6 months using ACRODAT®. Results According to ACRODAT®, 48.2%, 31.8% and 20.0% of a total of 111 patients were classified as having a stable disease (S), mild disease activity (M-DA) and significant disease activity (S-DA) respectively. ACRODAT® classification of disease activity significantly correlated with physicians’ opinion, with a moderate inter-rater agreement and a specificity of 92.45% (PPV = 86.21%). No correlation was found between IGF-I levels and severity of symptoms or quality of life (QoL). A decision to take clinical action was significantly more frequent in S-DA and M-DA patients than S patients but no action was taken on 5 (22.7%) and 27 (77.1%) S-DA and M-DA patients, respectively Conclusions ACRODAT® detected disease activity in 51.8% of patients. Interestingly, although M-DA and S-DA patients were likely to be in the process of being controlled, action was not always taken on these patients. ACRODAT® is a validated and highly specific tool that may be useful to routinely monitor acromegaly and to identify patients with non-obvious disease activity by incorporating “patient-centred” parameters like symptoms and QoL to the clinical evaluation of acromegaly.

scholarly journals Acromegaly Disease Activity According to ACRODAT®, in Spain: ACROVAL Study

2021 ◽  
Author(s):  
Monica Marazuela ◽  
Concepción Blanco ◽  
Ignacio Bernabeu ◽  
Edelmiro Menendez ◽  
Rocío Villar ◽  
...  
Keyword(s):  
Disease Activity ◽  
Clinical Evaluation ◽  
Cross Sectional Study ◽  
Patient Centered ◽  
Cross Sectional ◽  
Mild Disease ◽  
Clinical Action ◽  
The Relationship

Abstract Objectives: To evaluate disease activity status using the Acromegaly Disease Activity Tool (ACRODAT®) in a cohort of Spanish acromegaly patients, to assess the relationship between the level of disease activity according to both ACRODAT® and the physicians’ clinical evaluation, and to study the potential discrepancies in the perception of symptoms between physicians and patients.Design: Multicenter, observational, descriptive and cross-sectional study. Methods: Disease activity was assessed in adult patients with acromegaly under pharmacological treatment during at least 6 months using ACRODAT®.Results: According to ACRODAT®, 48.2%, 31.8% and 20.0% of a total of 111 patients were classified as having a stable disease (S), mild disease activity (M-DA) and significant disease activity (S-DA) respectively. ACRODAT® classification of disease activity significantly correlated with physicians’ opinion, with a moderate inter-rater agreement and a specificity of 92.45% (PPV=86.21%). No correlation was found between IGF-1 levels and severity of symptoms or quality of life (QoL). A decision to take clinical action was significantly more frequent in S-DA and M-DA patients than S patients but no action was taken on 5 (22.7%) and 27 (77.1%) S-DA and M-DA patients, respectivelyConclusions: ACRODAT® detected disease activity in 51.8% of patients. Interestingly, although M-DA and S-DA patients were likely to be in the process of being controlled, action was not always taken on these patients. ACRODAT® is a validated and highly specific tool that may be useful to routinely monitor acromegaly and to identify patients with non-obvious disease activity by incorporating “patient-centered” parameters like symptoms and QoL to the clinical evaluation of acromegaly.

scholarly journals Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
O. Zargari ◽  
E. Kazemnezhad Leyli ◽  
S. Z. Azimi
Keyword(s):  
Psoriatic Arthritis ◽  
Severe Disease ◽  
Cross Sectional Study ◽  
Joint Involvement ◽  
Sectional Study ◽  
Northern Iran ◽  
Cross Sectional ◽  
The Relationship ◽  
Nail Involvement

Background. Psoriatic arthritis (PsA) results in an increased burden of psoriasis and impairs both quality of life and an individual’s functional capacity. The relationship between nail involvement and PsA in psoriasis is not fully characterized. Aim. To evaluate the frequency and characteristics of nail involvement in psoriatic patients and to assess the relationship with joint involvement. Methods. A total of 197 patients with moderate-to-severe psoriasis were consecutively invited to participate in this cross-sectional study. The patients are divided into two groups: those with and those without psoriatic arthritis. Results. 69.5% of psoriatic (137 out of 197) patients had nail involvement. The most common nail abnormality was onycholysis, followed by pitting and oil droplet changes. Nail involvement was more common in patients with psoriatic arthritis (82.1% versus 57.8%, p=0.001). Conclusion. Nail involvement is commonly associated with PsA. Onycholysis, splinter hemorrhage, and oil drop were significantly more common in the PsA group as opposed to patients with just skin findings. In general, psoriatic patients with arthritis had more severe disease.

scholarly journals Quality of life in adolescents with primary headaches

2013 ◽  
Vol 53 (6) ◽  
pp. 350
Author(s):  
Naomi Riahta ◽  
Muhammad Ali ◽  
Bistok Saing ◽  
Yazid Dimyati ◽  
Johannes Saing
Keyword(s):  
Quality Of Life ◽  
Cross Sectional Study ◽  
Primary Headaches ◽  
Sectional Study ◽  
Quality Oflife ◽  
Cross Sectional ◽  
The Mean ◽  
Common Problems

Background Headaches are common problems in adults,adolescents, and children. Headaches impact a child's life, theirfamily life, and even society. An assessment of quality of life inadolescents with primary headaches may help to determine actionsnecessary to improve the quality of life of these patients.Objective To assess the quality oflife of adolescents with primaryheadach es compared to healthy adolescents.Methods We conducted a cross-sectional study in December2009 on adolescents aged 13 to 18 years. The headache groupconsisted of children with primary headaches according to theInternational Classification of Headache Disarders and the controlgroup consisted of healthy adolescents. Subjects were selected byconsecutive sampling, with 75 subjects in each group. Subjectsfilled the Pediatric Quality of Life Inventary version 4.0 (PedsQL4.0) questionnaire.Results The mean PedsQL total score was significantly lowerin the headache group than in the contra 1 group [ l 7 5. 7 vs.392.2, respectively, (95%CI of differences -28.l to -219.3, P =0.001)]. However, out of23 items in the questionnaire, 9 werenot significantly different between the headache and controlgroups.Conclusions Primary headaches in adolescents is associatedwith lower quality of life. Most quality of life domains scoresare significantly lower in adolescents with primary headachescompared to those without primary headaches.

scholarly journals Factors associated with disease-specific quality of life in Taiwanese patients with ankylosing spondylitis: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e028966
Author(s):  
Ming-Chi Lu ◽  
Kuang-Yung Huang ◽  
Chien-Hsueh Tung ◽  
Bao-Bao Hsu ◽  
Cheng-Han Wu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Dietary Habit ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Disease Specific

ObjectiveThe aim of this study was to assess the factors associated with disease-specific quality of life in Taiwanese patients with ankylosing spondylitis.DesignA cross-sectional study.SettingA regional teaching hospital in southern Taiwan.ParticipantsAdult patients with ankylosing spondylitis recruited from the outpatient rheumatology clinics of the study hospital.Primary outcome measureDisease-specific quality of life assessed by the Evaluation of Ankylosing Spondylitis Quality of Life (EASi-QoL).ResultsOf the 265 patients, 57% were 20–49 years of age, with a male preponderance (75.5%). Multiple stepwise linear regression analysis indicated that a higher disease activity, assessed by the Ankylosing Spondylitis Disease Activity Score, was significantly and independently associated with a lower quality of life in all four domains (physical function, disease activity, emotional well-being and social participation) of the EASi-QoL. In addition, various independent factors, including educational level, nature of occupation, disease duration, dietary habit and body mass index, were significantly associated with different domains of the EASi-QoL.ConclusionsOur findings indicated that, in addition to disease activity and perceived health status, a number of other factors could significantly impact the different aspects of quality of life in patients with ankylosing spondylitis, which warrant special consideration and support from healthcare providers.

scholarly journals The relationship between quality of life and social support among nurses: A cross-sectional study

2019 ◽  
Vol 28 (2) ◽  
pp. 242
Author(s):  
Samira Jafari ◽  
Fatemeh Shojaei ◽  
Maryam Puryaghoob ◽  
Malihe Babahaji ◽  
SomayyeGhavipanje Rezaei
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

scholarly journals The Relationship Between Social Support From Family and Quality of Life Among Cancer Patients: A Cross-Sectional Study

2020 ◽  
Vol 30 (4) ◽  
pp. 217-223
Author(s):  
Ismail Toygar ◽  
Öznur Usta Yeşilbalkan ◽  
Merve Kürkütlü ◽  
Tuğba Akgün
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Cancer Patients ◽  
Perceived Social Support ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
The Relationship

Introduction: Improving the Quality of Life (QoL) is considered one of the main objectives in the care of cancer patients. Achieving this objective, it is essential to determine the factors affecting QoL in cancer patients. The studies in the literature have determined the effects of various factors on QoL but social support from family has remained to be studied.  Objective: The present study aimed to determine the relationship between perceived social support from family and QoL in cancer patients. Materials and Methods: This cross-sectional study was conducted in an oncology unit of a university hospital in İzmir City, Turkey, from March to October 2019. A convenience sample of 276 cancer patients participated in the study. A patient identification form, the Perceived Social Support from family scale (PSS-Family), and the Quality of Life index-cancer version (QLI-C) were used for data collection. The scores of PSS-Family and QLI-C range from 0 to 20 and from 66 to 396, respectively. Regression analysis was used to estimate the effect of perceived social support from family on QoL. Results: Of the participants, 65.2% were female. The Mean±SD age of the study sample was 47.5±14.4 years. Also, the Mean±SD scores of PSS-Family and QLI-C were 16.43±3.01 and 307.77±27.48, respectively. Regression analysis revealed that perceived social support from family was associated with a relative increase in QoL index (B=3.44, P=0.001, R2=0.141). Conclusion: Perceived social support from family is positively associated with QoL in cancer patients. Nurses should consider this relationship when they plan to improve the QoL of cancer patients.

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