Cellular Uptake and In Vitro Drug Release Studies on Paclitaxel-Loaded Poly(caprolactone)-Grafted Dextran Copolymeric Nanoparticles

2009 ◽  
Vol 5 (1-4) ◽  
pp. 42-49 ◽  
Author(s):  
P. Prabu ◽  
Atul A. Chaudhari ◽  
J. A. Ko ◽  
N. Dharmaraj ◽  
S. Y. Park ◽  
...  
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Poly Caprolactone

Synthesis, Characterization and in-vitro drug release studies of a macromolecular prodrug of Didanosine.

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Neeraj Agrawal ◽  
M.J. Chandrasekar ◽  
U.V. Sara ◽  
Rohini A.
Keyword(s):  
Drug Release ◽  
Drug Level ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Alkaline Environment ◽  
Stomach Acid ◽  
Release Studies ◽  
Macromolecular Prodrug

A macromolecular prodrug of didanosine (ddI) for oral administration was synthesized and evaluated for in-vitro drug release profile. Didanosine was first coupled to 2-hydroxy ethyl methacrylate (HEMA) through a succinic spacer to form HEMA-Suc-ddI monomeric conjugate which was subsequently polymerized to yield Poly(HEMA-Suc-ddI) conjugate. The structures of the synthesized compounds were characterized by FT-IR, Mass and 1H-NMR spectroscopy. The prodrug was subjected for in-vitro drug release studies in buffers of pH 1.2 and 7.4 mimicking the upper and lower GIT. The results showed that the drug release from the polymeric backbone takes place in a sustained manner over a period of 24 h and the amount of drug released was comparatively higher at pH 7.4 indicating that the drug release takes place predominantly at the alkaline environment of the lower GIT rather than at the acidic environment of the upper GIT. This pH dependent sustained drug release behavior of the prodrug may be capable of reducing the dose limiting toxicities by maintaining the plasma drug level within the therapeutic range and increasing t1/2 of ddI. Moreover, the bioavailability of the drug should be improved as the prodrug releases ddI predominantly in the alkaline environment which will reduce the degradation of ddI in the stomach acid.

scholarly journals DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE

2018 ◽  
Vol 8 (5-s) ◽  
pp. 235-239
Author(s):  
NILESH M MAHAJAN ◽  
Kalyanee Wanaskar ◽  
Yogesh Bhutada ◽  
Raju Thenge ◽  
Vaibhav Adhao
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
In Vitro Release ◽  
Matrix Tablet ◽  
Direct Compression ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Tablet Properties ◽  
Vitro Release

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15,  it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for optimize batch was found to 94.62%.  Hence it can be conclude that Nateglinide extended release matrix tablet can prepared by using HPMC. The swollen tablet also maintains its physical integrity during the drug release study Keywords: Tablet, in-vitro drug release, Nateglinide, HPMC

Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies

2018 ◽  
Vol 194 ◽  
pp. 311-318 ◽  
Author(s):  
Muthukumaran C. ◽  
Kanmani B.R. ◽  
Sharmila G. ◽  
Manoj Kumar N. ◽  
Shanmugaprakash M.
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Release Studies

Glucosamine-carrying temperature- and pH-sensitive microgels: Preparation, characterization, and in vitro drug release studies

2008 ◽  
Vol 322 (1) ◽  
pp. 333-341 ◽  
Author(s):  
Dayong Teng ◽  
Jingli Hou ◽  
Xinge Zhang ◽  
Xin Wang ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Ph Sensitive ◽  
In Vitro Drug Release ◽  
Release Studies

Preparation, characterization and in vitro drug release studies of novel polymeric nanoparticles

2006 ◽  
Vol 323 (1-2) ◽  
pp. 146-152 ◽  
Author(s):  
Surendra Nimesh ◽  
Romila Manchanda ◽  
Rupesh Kumar ◽  
Amit Saxena ◽  
Preeti Chaudhary ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymeric Nanoparticles ◽  
In Vitro Drug Release ◽  
Release Studies

scholarly journals Development of Anti-diabetic Niosomes Formulation Containing Metformin and Gliclazide

2017 ◽  
Vol 5 (02) ◽  
pp. 24-28
Author(s):  
B. Kumar ◽  
G. Jeyabalan
Keyword(s):  
Drug Release ◽  
In Vitro Release ◽  
In Vitro Study ◽  
Hplc Method ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Continuous Delivery ◽  
Span 60

Metformin/Gliclazide niosomes were formulated with span 60 by ether injection method. Three batches MG1-MG3 were prepared in order to study influence of drug polymer ratio on the niosomes formation and in vitro drug release. The formulated niosomes were characterized by drug entrapment, vesicle size determination, and in vitro drug release. Optimized concentration of span 60 and cholesterol was found to be 1:1. In the in-vitro study, niosomes formulation of MG1 showed high percentage of drug release, 40.18 to 45.75% for about 8 hrs. This indicated that this batch of niosomes formulation exhibit sustained drug release pattern as the niosomes act as reservoir system for continuous delivery of drug. The quantity of Metformin/Gliclazide present in the niosomes and the release medium were estimated by a validated HPLC method. The formulated niosomes had acceptable physicochemical characters and released the drug over 6-8 h. The data obtained from in vitro release studies were fitted with various kinetic models and was found to follow Higuchi kinetics.

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