scholarly journals Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder

2022 ◽  
Author(s):  
Kevser Nalbant ◽  
Semih Erden ◽  
Abdullah Yazar ◽  
İbrahim Kılınç
Keyword(s):  
Autism Spectrum Disorder ◽  
Symptom Severity ◽  
Barrier Function ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Epithelial Barrier ◽  
Epithelial Barrier Function

scholarly journals Investigation of the Relation Between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder

2021 ◽  
Author(s):  
Kevser Nalbant ◽  
Semih Erden ◽  
Abdullah Yazar ◽  
İbrahim Kılınç
Keyword(s):  
Autism Spectrum Disorder ◽  
Barrier Function ◽  
Rating Scale ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Enzyme Linked Immunosorbent Assay ◽  
Epithelial Barrier ◽  
Control Group ◽  
Epithelial Barrier Function ◽  
Children With Asd

Abstract Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as well as restricted, repetitive patterns of behaviors, interests, or activities. A number of biological abnormalities have been reported in ASD. Therefore the possible role of biological abnormalities in etiopathogenesis arouses research interest in this area. This is a case-control design study evaluating epithelial barrier function by comparing serum concentrations of occludin and zonulin in children with ASD (n = 60) and controls (n = 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autistic symptom levels of all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels item mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment.

scholarly journals Effects of Improvisational Music Therapy vs Enhanced Standard Care on Symptom Severity Among Children With Autism Spectrum Disorder

JAMA ◽  
2017 ◽  
Vol 318 (6) ◽  
pp. 525 ◽  
Author(s):  
Lucja Bieleninik ◽  
Monika Geretsegger ◽  
Karin Mössler ◽  
Jörg Assmus ◽  
Grace Thompson ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Music Therapy ◽  
Symptom Severity ◽  
Standard Care ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Improvisational Music Therapy

The Relationship of Symptom Severity and Pretend Play in Children With Autism Spectrum Disorder (ASD)

2020 ◽  
Vol 74 (4_Supplement_1) ◽  
pp. 7411500049p1
Author(s):  
Yu-Ling Chen ◽  
I-Ning Fu ◽  
Meng-Ru Liu ◽  
Yen-Ting Yu ◽  
Hsing-Jung Li ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Symptom Severity ◽  
Pretend Play ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Relationship Of ◽  
The Relationship

Temperament influences the relationship between symptom severity and adaptive functioning in children with autism spectrum disorder

Autism ◽  
2020 ◽  
Vol 24 (8) ◽  
pp. 2057-2070
Author(s):  
Vivian Lee ◽  
Eric Duku ◽  
Lonnie Zwaigenbaum ◽  
Teresa Bennett ◽  
Peter Szatmari ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Symptom Severity ◽  
Adaptive Functioning ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Autism Symptoms ◽  
Adaptive Functioning Skills ◽  
The Impact ◽  
The Relationship

Temperament is a construct that is relatively stable over time but varies between individuals. Research suggests that children with autism spectrum disorder have a ‘reactive’ temperament profile when compared to peers with or without disabilities. However, our understanding of how temperament varies within children with autism and how it relates to child symptoms and outcomes is limited. This study aimed to (a) explore the variation of individual temperament traits within a sample of school-aged children with autism to determine whether subgroups of children with similar trait profiles emerge and (b) examine whether temperament influences the relationship between autism symptoms and adaptive functioning outcomes. Results revealed that children with autism can be classified empirically into two distinct profiles – ‘Even’ and ‘Reactive’ temperaments. Correlational and hierarchical regression analyses indicated that both temperament profiles and baseline symptom severity predicted adaptive functioning outcomes 1 year later. There was a significant interaction between temperament and symptom severity, suggesting temperament can influence the impact of increasing symptom severity on adaptive functioning skills in children with autism. Study findings highlight the importance of considering temperament in understanding the individual differences that influence the development of daily functioning and developmental outcomes in children with autism. Lay Abstract Temperament is often thought of as behavioural traits that are relatively stable over time but can vary between individuals. Children diagnosed with autism spectrum disorder are often characterized as having ‘reactive’ and ‘negative’ temperaments when compared to same-aged peers with or without disabilities, which can negatively impact the development of adaptive functioning skills but little is known about variations of temperament between individual children diagnosed with autism spectrum disorder. This study aimed to (a) explore the variation of individual temperament traits within a sample of school-aged children with autism spectrum disorder to determine whether subgroups with similar trait profiles emerge and (b) examine whether temperament influences the relationship between autism symptoms and adaptive functioning outcomes. Results from our dataset suggest that children diagnosed with autism spectrum disorder fit under two profiles: ‘even’ and ‘reactive’. Furthermore, our analysis shows that temperament can influence the impact of increasing symptom severity on adaptive functioning skills in children with autism spectrum disorder. Study findings highlight the importance of considering temperament when trying to understand the individual differences that influence the development of functioning and developmental outcomes in children with autism spectrum disorder.

Electrodermal Variability and Symptom Severity in Children with Autism Spectrum Disorder

2017 ◽  
Vol 47 (4) ◽  
pp. 1062-1072 ◽  
Author(s):  
Rachel M. Fenning ◽  
Jason K. Baker ◽  
Brian R. Baucom ◽  
Stephen A. Erath ◽  
Mariann A. Howland ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Symptom Severity ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Children with Autism Spectrum Disorder of All Ages, Levels of Symptom Severity and General Cognitive Ability Display Low Processing Speed Index Scores Warranting Special Educational Assistance

2021 ◽  
Author(s):  
M. Linnenbank ◽  
R. Feldmann ◽  
G. Schulte-Körne ◽  
S. Beimdiek ◽  
E. Strittmatter
Keyword(s):  
Autism Spectrum Disorder ◽  
Cognitive Ability ◽  
School Children ◽  
Processing Speed ◽  
Symptom Severity ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
General Cognitive Ability ◽  
Children With Asd

AbstractThe processing speed index (PSI) of the Wechsler intelligence scale for children (WISC-IV) has been found to predict a child's level of academic functioning. The consistently reported PSI weakness in children with autism spectrum disorder (ASD) therefore warrants special assistance and attempts at compensation for the disadvantages associated with these children's low PSI. We investigated the association of PSI scores with age, general cognitive ability [as measured by full-scale IQ (FSIQ)], symptom severity and discrepancy between the WISC-IV indices verbal comprehension (VCI) and perceptual reasoning (PRI) in 101 school children with ASD. The PSI weakness in children with ASD was not related to age, FSIQ, VCI-PRI discrepancy or any of the symptom measures. These findings suggest that school children with ASD independent of their age, level of cognitive ability, VCI-PRI profile and most notably independent of their symptom severity should be entitled to special assistance and compensation in educational settings.

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