scholarly journals Zika Virus Infection of Human Mesenchymal Stem Cells Promotes Differential Expression of Proteins Linked to Several Neurological Diseases

2018 ◽  
Vol 56 (7) ◽  
pp. 4708-4717 ◽  
Author(s):  
Walter O. Beys-da-Silva ◽  
Rafael L. Rosa ◽  
Lucélia Santi ◽  
Markus Berger ◽  
Sung Kyu Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Virus Infection ◽  
Differential Expression ◽  
Zika Virus ◽  
Neurological Diseases ◽  
Human Mesenchymal Stem Cells ◽  
Zika Virus Infection

scholarly journals Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection

2017 ◽  
Vol 8 (3) ◽  
pp. 715-727 ◽  
Author(s):  
Erica L. McGrath ◽  
Shannan L. Rossi ◽  
Junling Gao ◽  
Steven G. Widen ◽  
Auston C. Grant ◽  
...  
Keyword(s):  
Stem Cells ◽  
Virus Infection ◽  
Neural Stem Cells ◽  
Zika Virus ◽  
Fetal Brain ◽  
Human Fetal Brain ◽  
Zika Virus Infection ◽  
Differential Responses

scholarly journals Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation

2020 ◽  
Vol 9 (11) ◽  
pp. 3654
Author(s):  
Youngpyo Nam ◽  
Dongyeong Yoon ◽  
Jungwan Hong ◽  
Min Sung Kim ◽  
Tae Yong Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Neurological Diseases ◽  
Human Mesenchymal Stem Cells ◽  
Therapeutic Effects ◽  
Muscle Coordination ◽  
M2 Polarization ◽  
Cerebellar Ataxias ◽  
Inflammatory Effect

Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.

scholarly journals Memory like NK cells display stem cell like properties after Zika virus infection

2020 ◽  
Vol 16 (12) ◽  
pp. e1009132
Author(s):  
Weshely Kujur ◽  
Oscar Murillo ◽  
Raju S. R. Adduri ◽  
Ramakrishna Vankayalapati ◽  
Nagarjun V. Konduru ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Stem Cell ◽  
Virus Infection ◽  
Nk Cells ◽  
Zika Virus ◽  
Gene Signature ◽  
Hematopoietic Stem ◽  
Zika Virus Infection ◽  
With Memory

NK cells have been shown to display adaptive traits such as memory formation akin to T and B lymphocytes. Here we show that Zika virus infection induces memory like NK cells that express CD27. Strikingly, these cells exhibit stem-like features that include expansion capacity, self-renewal pathway, differentiation into effector cells, longer telomeres and gene signature associated with hematopoietic stem cell (HSC) progenitors. This subset shared transcriptional and epigenetic changes with memory CD8 T cells, stem cells and stem like T cells. These NK cells with memory and stem cell features, which we term “NK memory stem cells”, demonstrated greater antiviral potential than CD27- or naïve CD27+ NK when adoptively transferred to Zika infected mice. Our results also suggest a role for the transcription factor TCF-1 in memory and stemness features of this NK subset. This study defines a unique TCF1hi CD27+ NK subset with memory capacity and stem cell features that play a role in antiviral immunity.

Differential Expression of Adhesion-Related Proteins and MAPK Pathways Lead to Suitable Osteoblast Differentiation of Human Mesenchymal Stem Cells Subpopulations

2015 ◽  
Vol 24 (21) ◽  
pp. 2577-2590 ◽  
Author(s):  
Margarita Leyva-Leyva ◽  
Annia López-Díaz ◽  
Lourdes Barrera ◽  
Alberto Camacho-Morales ◽  
Felipe Hernandez-Aguilar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Differential Expression ◽  
Osteoblast Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Mapk Pathways ◽  
Related Proteins

scholarly journals Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

2019 ◽  
Vol 10 (4) ◽  
Author(s):  
Gioacchin Iannolo ◽  
Maria Rita Sciuto ◽  
Nicola Cuscino ◽  
Roberto Pallini ◽  
Bruno Douradinha ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Virus Infection ◽  
Zika Virus ◽  
Glioblastoma Stem Cells ◽  
Zika Virus Infection

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

The Effect of Link N on the Differentiation of Human Mesenchymal Stem Cells

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1320001-s-0032-1320001
Author(s):  
F. Mwale ◽  
H. T. Wang ◽  
L. Haglund ◽  
P. J. Roughley ◽  
J. Antoniou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Generation of human mesenchymal stem cells lacking diabetoporosity-associated miRNAs using CRISPR/Cas9

2020 ◽  
Author(s):  
I Foessl ◽  
A Groselj-Strele ◽  
JC Piswanger-Sölkner ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells
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