High Grade Myoepithelial Carcinoma of Maxillary Sinus with Extensive Rhabdoid Differentiation and INI-1 Loss: Expanding the Histopathological Spectrum of Sinonasal Carcinoma

2021 ◽  
Author(s):  
Sunil Pasricha ◽  
Meenakshi Kamboj ◽  
Ankush Jajodia ◽  
Mudit Aggarwal ◽  
Gurudutt Gupta ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Sinonasal Carcinoma ◽  
Rhabdoid Differentiation

scholarly journals High grade myoepithelial carcinoma of the maxillary si-nus

2017 ◽  
Vol 5 (2) ◽  
pp. 143
Author(s):  
Bharati Patil ◽  
Sushmini Hegde ◽  
Karthik D Yadav
Keyword(s):  
Parotid Gland ◽  
Maxillary Sinus ◽  
Salivary Glands ◽  
Rare Case ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Rare Tumor ◽  
Frequent Site

Myoepithelial carcinoma is a rare tumor of salivary glands, the most frequent site being the parotid gland. Myoepithelial carcinoma of the maxillary sinus has only been reported very few times. As the lesion is very rare in the maxillary sinus and due to the lack of specific guidelines for its treatment, its prognosis remains to be poor. We report a rare case of myoepithelial carcinoma in the maxillary sinus and discuss its diagnostic and therapeutic aspects.

scholarly journals Soft tissue myoepithelial carcinoma

2006 ◽  
Vol 63 (6) ◽  
pp. 611-614 ◽  
Author(s):  
Zorica Stojsic ◽  
Dimitrije Brasanac ◽  
Dragoljub Bacetic ◽  
Radmila Jankovic ◽  
Neda Drndarevic
Keyword(s):  
Soft Tissue ◽  
Cell Types ◽  
Giant Cells ◽  
Myoepithelial Cells ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Cytologic Atypia ◽  
S 100 ◽  
Myxoid Matrix ◽  
Subcutaneous Adipose

Background. Myoepitheliomas are tumors composed predominantly or exclusively of myoepithelial cells, usually arising in salivary glands. Cutaneous/soft tissue localization is very rare, especially for the malignant myoepitheliomas. Case report. We presented a case of myoepithelial carcinoma involving subcutaneous adipose tissue of the left forearm in a woman aged 62 years. The tumor was composed of epithelioid and hyaline cell types, arranged in diffuse sheets, nests and loose clusters within hyalinized and myxoid matrix. The neoplasm displayed high-grade cytologic atypia with some cells having pleomorphic, hyperchromatic nuclei, and others showing vesicular nuclei, large nucleoli with scattered bizarre giant cells. High mean mitotic count of 7 mitoses/10 high power fields and extensive necrosis favored the diagnosis of malignancy. Immunohistochemical staining was positive for cytokeratin (AE1/AE3), epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, and vimentin. Conclusion. Considering the subcutaneous localization, myoepithelial immunophenotype and high-grade cytologic atypia the neoplasm was classified as a soft-tissue myoepithelial carcinoma.

scholarly journals High-Grade Sinonasal Carcinoma: Classification Through Molecular Profiling

2019 ◽  
Vol 143 (11) ◽  
pp. 1416-1419 ◽  
Author(s):  
Julie Guilmette ◽  
Peter M. Sadow
Keyword(s):  
Molecular Profiling ◽  
Undifferentiated Carcinoma ◽  
Clinical Impact ◽  
High Grade ◽  
Lymphoepithelial Carcinoma ◽  
Nut Midline Carcinoma ◽  
Sinonasal Carcinoma ◽  
Epithelial Neoplasms ◽  
Well Differentiated ◽  
Tumor Entities

High-grade sinonasal carcinomas are a cohort of malignant epithelial neoplasms arising in the sinonasal cavities with distinct, ominous morphologic features or lacking well-differentiated features that might otherwise classify them as less biologically worrisome. Recent advances in molecular profiling have led to the identification of several distinct tumor entities previously grouped together. These molecularly distinct lesions include NUT (midline) carcinoma, INI1 (SMARCB1)-deficient carcinoma, SMARCA4-deficient sinonasal carcinoma, and novel IDH-mutant sinonasal undifferentiated carcinoma, in addition to the previously described lymphoepithelial carcinoma that may also be included in the differential diagnosis. The discovery of these distinct molecular tumor profiles may have significant clinical impact as targeted molecular-based therapeutics continue to evolve, and they may offer some respite for patients who have these highly aggressive cancers.

scholarly journals Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

2012 ◽  
Vol 7 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Prokopios P. Argyris ◽  
Stefan E. Pambuccian ◽  
Zuzan Cayci ◽  
Charanjeet Singh ◽  
Konstantinos I. Tosios ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Lacrimal Gland ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Review Of Literature ◽  
Adenoid Cystic ◽  
High Grade Transformation

HPV-Related Multiphenotypic Sinonasal Carcinoma: A Unique Case

2019 ◽  
Vol 27 (8) ◽  
pp. 888-892 ◽  
Author(s):  
Daniel Ching ◽  
Shadi Pirasteh ◽  
Chanh Ly
Keyword(s):  
Salivary Gland ◽  
Human Papillomavirus ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Unique Case ◽  
Sinonasal Carcinoma ◽  
Adenoid Cystic ◽  
Gland Carcinoma ◽  
Multiphenotypic Sinonasal Carcinoma ◽  
High Risk Hpv

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a recently described neoplasm that presents only in the sinonasal tract, displays features of both a surface-derived carcinoma and a salivary gland carcinoma, and is associated with high-risk HPV, specifically HPV type 33. Majority of the cases display high-grade histologic features, but HMSC paradoxically behaves in a relatively indolent fashion. Distinguishing HMSC from other histologic mimickers is essential as the management and prognosis are significantly different. In this article, we present a unique case of HMSC and review the literature.

scholarly journals Case report of myoepithelial carcinoma of maxillary sinus

2020 ◽  
Vol 10 (1) ◽  
pp. 85-87
Author(s):  
Ahmad Liaquat ◽  
Nabeela Riaz ◽  
Arun Kumar Shah
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Maxillary Sinus ◽  
De Novo ◽  
Minor Salivary Gland ◽  
Myoepithelial Carcinoma ◽  
Titanium Mesh ◽  
Total Maxillectomy ◽  
Orbital Floor Reconstruction ◽  
Rare Malignancy

Myoepithelial carcinoma of the salivary gland is extremely rare malignancy. It may arise ei­ther in recurrent or pre existing pleomorphic adenoma or de novo in salivary glands. We herein present the case report of 35 years old male patient who presented to us with myo­epithelial carcinoma of minor salivary gland of right maxillary sinus. Right total maxillectomy was done and orbital floor reconstruction was done with titanium mesh.

scholarly journals Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karl Grenier ◽  
Gulbeyaz Altinel ◽  
Zari Dastani ◽  
Atilla Omeroglu
Keyword(s):  
Clear Cell ◽  
Phyllodes Tumor ◽  
Myoepithelial Cells ◽  
Metaplastic Carcinoma ◽  
Myoepithelial Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Epithelial Myoepithelial Carcinoma ◽  
Rhabdoid Differentiation ◽  
Rhabdoid Features

Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.

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