Primary high-grade myoepithelial carcinoma of the lung: A study of three cases illustrating frequent SMARCB1-deficiency and review of the literature

2021 ◽  
pp. 151759
Author(s):  
Abbas Agaimy ◽  
Inna Naroditsky ◽  
Ofer Ben-Izhak
Keyword(s):  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Review Of The Literature

scholarly journals Nasal Epithelial Myoepithelial Carcinoma: An Unusual Cause of Epiphora, a Case Report and Review of the Literature

2015 ◽  
Vol 6 (2) ◽  
pp. ar.2015.6.0127 ◽  
Author(s):  
Juliette O. Flam ◽  
Christopher D. Brook ◽  
Rachel Sobel ◽  
John C. Lee ◽  
Michael P. Platt
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Nasal Cavity ◽  
Surgical Excision ◽  
Myoepithelial Carcinoma ◽  
Review Of The Literature ◽  
Nasal Symptoms ◽  
First Case ◽  
Nasal Tumor ◽  
Epithelial Myoepithelial Carcinoma

Introduction Epithelial myoepithelial carcinoma (EMC) of the nasal cavity is a rare tumor, and here we describe the first case of EMC of the nasal cavity presenting with epiphora. A case presentation and review of the literature is provided. Methods A case report is described of a 63-year-old man who presented with unilateral epiphora and was found via a thorough history and physical examination to have a nasal tumor. The physical examination consisted of an ocular examination, including probing and irrigation, and a detailed nasal examination (anterior rhinoscopy, nasal endoscopy). The nasal examination was prompted by the patient's report of concurrent nasal symptoms during history taking. Immunohistochemistry subsequently identified the nasal tumor as EMC. A literature search was performed to gain insights into similar malignancies of the nasal cavity. Results Eight cases of EMC of the nasal cavity were identified in the literature, none of the patients presented with epiphora. The case presented here resulted in resolution of the patient's symptoms and no evidence of disease after surgical excision. Conclusion Epithelial myoepithelial is a rare salivary gland malignancy that can arise in the nasal cavity. Unilateral epiphora with concurrent nasal symptoms should prompt nasal cavity examination for the possibility of an obstructive tumor.

High grade dedifferentiated liposarcoma. Case report and review of the literature

2010 ◽  
Vol 34 (8) ◽  
pp. 737-739
Author(s):  
G. García-Fadrique ◽  
E. Morán Pascual ◽  
G. Morales Solchaga ◽  
A. Soto ◽  
J.F. Morera ◽  
...  
Keyword(s):  
Case Report ◽  
Dedifferentiated Liposarcoma ◽  
High Grade ◽  
Review Of The Literature

scholarly journals Soft tissue myoepithelial carcinoma

2006 ◽  
Vol 63 (6) ◽  
pp. 611-614 ◽  
Author(s):  
Zorica Stojsic ◽  
Dimitrije Brasanac ◽  
Dragoljub Bacetic ◽  
Radmila Jankovic ◽  
Neda Drndarevic
Keyword(s):  
Soft Tissue ◽  
Cell Types ◽  
Giant Cells ◽  
Myoepithelial Cells ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Cytologic Atypia ◽  
S 100 ◽  
Myxoid Matrix ◽  
Subcutaneous Adipose

Background. Myoepitheliomas are tumors composed predominantly or exclusively of myoepithelial cells, usually arising in salivary glands. Cutaneous/soft tissue localization is very rare, especially for the malignant myoepitheliomas. Case report. We presented a case of myoepithelial carcinoma involving subcutaneous adipose tissue of the left forearm in a woman aged 62 years. The tumor was composed of epithelioid and hyaline cell types, arranged in diffuse sheets, nests and loose clusters within hyalinized and myxoid matrix. The neoplasm displayed high-grade cytologic atypia with some cells having pleomorphic, hyperchromatic nuclei, and others showing vesicular nuclei, large nucleoli with scattered bizarre giant cells. High mean mitotic count of 7 mitoses/10 high power fields and extensive necrosis favored the diagnosis of malignancy. Immunohistochemical staining was positive for cytokeratin (AE1/AE3), epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, and vimentin. Conclusion. Considering the subcutaneous localization, myoepithelial immunophenotype and high-grade cytologic atypia the neoplasm was classified as a soft-tissue myoepithelial carcinoma.

scholarly journals High-grade testicular diffuse B lymphoma, a rare localization: a case report and review of the literature

2020 ◽  
Vol 11 (1) ◽  
pp. 23-25
Author(s):  
Zakaria Ahmed Youbi ◽  
Sena Yossi ◽  
Pierre Sesques ◽  
Hassan Jouhadi
Keyword(s):  
Case Report ◽  
High Grade ◽  
Review Of The Literature ◽  
B Lymphoma

scholarly journals Sinonasal epithelial-myoepithelial carcinoma: Report of a novel subsite and review of the literature

2018 ◽  
Vol 9 ◽  
pp. 215265671876422 ◽  
Author(s):  
Theodore A. Schuman ◽  
Adam J. Kimple ◽  
Claire H. Edgerly ◽  
Charles S. Ebert ◽  
Adam M. Zanation ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Medical Literature ◽  
Clinical Course ◽  
Myoepithelial Carcinoma ◽  
Review Of The Literature ◽  
Craniofacial Resection ◽  
Primary Location ◽  
Epithelial Myoepithelial Carcinoma ◽  
Ethmoid Sinuses ◽  
Uncommon Neoplasm

Background Epithelial-myoepithelial carcinoma (EMC) is a rare tumor of the major and minor salivary glands. Sinonasal EMC is extremely uncommon and hitherto not described within the frontal or ethmoid sinuses. Objective To present a novel sinonasal subsite and review the literature regarding sinonasal EMC. Methods A case of frontoethmoidal EMC was presented. A medical literature data base was queried from January 1, 1950, to August 8, 2017, for all reports of sinonasal EMC. Results A 69-year-old man underwent combined open and endoscopic craniofacial resection of a right frontoethmoidal EMC, a previously undescribed primary location for this tumor. A comprehensive review of the literature revealed 13 additional cases of sinonasal EMC. Conclusion EMC is an uncommon neoplasm typically found in the major salivary glands; occurrence in the nose or paranasal sinuses is extremely rare. EMC often follows an indolent clinical course, although, in a minority of cases, particularly in large tumors with nuclear atypia, more aggressive behavior may be observed.

scholarly journals Carcinosarcoma of the bladder: case report and review of the literature

2013 ◽  
Vol 5 (4) ◽  
pp. 69
Author(s):  
Arda Akoluk ◽  
Yagil Barazani ◽  
Denisa Slova ◽  
Sovrin Shah ◽  
Basir Tareen
Keyword(s):  
Case Report ◽  
Radical Cystectomy ◽  
Transurethral Resection ◽  
Bladder Tumour ◽  
Muscularis Propria ◽  
Complete Resection ◽  
High Grade ◽  
Review Of The Literature ◽  
Almost All ◽  
Disease Free

Primary osteosarcomas of the bladder account for about 0.04% ofbladder neoplasms. Most of the patients in the literature expiredwithin 6 months and, in almost all of the cases in the literature,radical cystectomy with postoperative chemotherapy was thetreatment choice. A 79-year-old gentleman presented with grosshematuria. Cystoscopy demonstrated a 2- to 3-cm tumour along thelateral wall of the bladder. The tumour was resected incompletelyvia initial transurethral resection of bladder tumour (TURBT), anda second TURBT was subsequently performed to fully resect theresidual mass. Surgical pathology from these 2 resections revealedosteosarcoma with invasion into the muscularis propria. Acystoprostatectomy was performed and final pathologic specimenrevealed high-grade CIS without evidence of residual osteosarcoma.Postoperatively, the patient did not receive chemotherapy orradiation and currently remains disease-free 2 years post-radicalcystectomy. Only 33 well-documented cases of primary osteosarcomaof the bladder have been reported to date. However, thereare only 3 cases in which TURBT resulted in complete resection.

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