The system of veterinary and sanitary measures in the CJSC "Makeevo" of the Zarayskiy municipal district of the Moscow region was studied during 2015-2016. The tests were carried out on 2232 cattle with age and sex composition: 965 cows, 206 heifers, 186 heifers (2014 year of birth), 52 bulls (2014 year of birth,) 426 heifers (2015 year of birth), 397 male calves (2015 year of birth). The system of veterinary and sanitary measures to prevent infectious diseases of cattle have been developed on the basis of modern scientific achievements, taking into account many years of practical experience in Russia, includes a set of measures: an analysis of the current situation in the farm; identification of urgent priority measures, specialists training on the farm, monitoring of the proposed measures implementation; elaboration of the farm development plan. The results of the recommendations production tests and the system of veterinary and sanitary measures on number of cattle in the dairy farm enterprise through the modernization of the production process are presented. Application of organizational-economic, sanitary, diagnostic, preventive and therapeutic measures was allowed to protect 99.25% of animals from necrobacteriosis.