Determination of Curcuminoids and Their Degradation Products in Turmeric (Curcuma longa) Rhizome Herbal Products by Non-aqueous Capillary Electrophoresis with Photodiode Array Detection

2016 ◽  
Vol 9 (9) ◽  
pp. 2567-2578 ◽  
Author(s):  
S. Anubala ◽  
R. Sekar ◽  
K. Nagaiah
Keyword(s):  
Capillary Electrophoresis ◽  
Degradation Products ◽  
Curcuma Longa ◽  
Photodiode Array Detection ◽  
Herbal Products ◽  
Photodiode Array ◽  
Array Detection

Determination of amphetamines in human whole blood by capillary electrophoresis with photodiode array detection

2002 ◽  
Vol 29 (6) ◽  
pp. 1073-1080 ◽  
Author(s):  
Gianpiero Boatto ◽  
Maria Virginia Faedda ◽  
Amedeo Pau ◽  
Battistina Asproni ◽  
Sonia Menconi ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Whole Blood ◽  
Photodiode Array Detection ◽  
Human Whole Blood ◽  
Photodiode Array ◽  
Array Detection

scholarly journals Development and Application of a Validated Stability-Indicating High-Performance Liquid Chromatographic Method Using Photodiode Array Detection for Simultaneous Determination of Granisetron, Methylparaben, Propylparaben, Sodium Benzoate, and Their Main Degradation Products in Oral Pharmaceutical Preparations

2011 ◽  
Vol 94 (5) ◽  
pp. 1447-1460 ◽  
Author(s):  
Ismail Hewala ◽  
Hamed El-Fatatry ◽  
Ehab Emam ◽  
Mokhtar Mabrouk
Keyword(s):  
Simultaneous Determination ◽  
Degradation Product ◽  
Sodium Benzoate ◽  
Degradation Products ◽  
Hydroxybenzoic Acid ◽  
Photodiode Array Detection ◽  
Main Degradation Product ◽  
Photodiode Array ◽  
Array Detection

Abstract A simple, rapid, and sensitive RP-HPLC method using photodiode array detection was developed and validated for the simultaneous determination of granisetron hydrochloride, 1-methyl-1H-indazole-3-carboxylic acid (the main degradation product of granisetron), sodium benzoate, methylparaben, propylparaben, and 4-hydroxybenzoic acid (the main degradation product of parabens) in granisetron oral drops and solutions. The separation of the compounds was achieved within 8 min on a SymmetryShield RP18 column (100 × 4.6 mm id, 3.5 μm particle size) using the mobile phase acetonitrile—0.05 M KH2PO4 buffered to pH 3 using H3PO4 (3+7, v/v). The photodiode array detector was used to test the purity of the peaks, and the chromatograms were extracted at 240 nm. The method was validated, and validation acceptance criteria were met in all cases. The robust method was successfully applied to the determination of granisetron and preservatives, as well as their degradation products in different batches of granisetron oral drops and solutions. The method proved to be sensitive for determination down to 0.04% (w/w) of granisetron degradation product relative to granisetron and 0.03% (w/w) 4-hydroxybenzoic acid relative to total parabens.

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