Quantitative comparison of hemodynamics in simulated and 3D angiography models of cerebral aneurysms by use of computational fluid dynamics

Computational fluid dynamics (CFD) has grown as a tool to help understand the hemodynamic properties related to the rupture of cerebral aneurysms. Few of these studies deal specifically with aneurysm growth and most only use a single time instance within the aneurysm growth history. The present retrospective study investigated four patient-specific aneurysms, once at initial diagnosis and then at follow-up, to analyze hemodynamic and morphological changes. Aneurysm geometries were segmented via the medical image processing software Mimics. The geometries were meshed and a computational fluid dynamics (CFD) analysis was performed using ANSYS. Results showed that major geometry bulk growth occurred in areas of low wall shear stress (WSS). Wall shape remodeling near neck impingement regions occurred in areas with large gradients of WSS and oscillatory shear index. This study found that growth occurred in areas where low WSS was accompanied by high velocity gradients between the aneurysm wall and large swirling flow structures. A new finding was that all cases showed an increase in kinetic energy from the first time point to the second, and this change in kinetic energy seems correlated to the change in aneurysm volume.

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A newly identified hemodynamic parameter to predict the thin-walled regions of unruptured cerebral aneurysms using a computational fluid dynamics analysis

World Neurosurgery ◽

10.1016/j.wneu.2021.05.107 ◽

2021 ◽

Author(s):

Hidehito Kimura ◽

Susumu Osaki ◽

Kosuke Hayashi ◽

Masaaki Taniguchi ◽

Yuichi Fujita ◽

...

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Cerebral Aneurysms ◽

Hemodynamic Parameter ◽

Dynamics Analysis ◽

Computational Fluid Dynamics Analysis ◽

Thin Walled ◽

Unruptured Cerebral Aneurysms

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Computational Fluid Dynamics in Cerebral Aneurysms

Recent Progress in the Management of Cerebrovascular Diseases ◽

10.1007/978-981-16-3387-4_5 ◽

2021 ◽

pp. 37-44

Author(s):

Ahmed Ansari ◽

Ishu Bishnoi ◽

Gowtham Devareddy

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Cerebral Aneurysms

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Comprehensive validation of computational fluid dynamics simulations of in-vivo blood flow in patient-specific cerebral aneurysms

Medical Physics ◽

10.1118/1.3675402 ◽

2012 ◽

Vol 39 (2) ◽

pp. 742-754 ◽

Cited By ~ 23

Author(s):

Qi Sun ◽

Alexandra Groth ◽

Til Aach

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Blood Flow ◽

Cerebral Aneurysms ◽

Patient Specific ◽

Computational Fluid Dynamics Simulations ◽

Dynamics Simulations

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Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms

Medical Physics ◽

10.1118/1.3483066 ◽

2010 ◽

Vol 37 (9) ◽

pp. 5054-5065 ◽

Cited By ~ 21

Author(s):

Qi Sun ◽

Alexandra Groth ◽

Matthias Bertram ◽

Irina Waechter ◽

Tom Bruijns ◽

...

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Experimental Validation ◽

Cerebral Aneurysms ◽

Computational Fluid Dynamics Simulations ◽

Dynamics Simulations

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WHICH MORPHOLOGIC AND HEMODYNAMIC CHARACTERISTICS PREDICT INTRACRANIAL FUSIFORM ANEURYSMS RUPTURE? A PATIENT-SPECIFIC COMPUTATIONAL FLUID DYNAMICS STUDY

Journal of Mechanics in Medicine and Biology ◽

10.1142/s0219519417500701 ◽

2017 ◽

Vol 17 (03) ◽

pp. 1750070

Author(s):

YAN CHEN ◽

YI-BIN FANG ◽

PENG-FEI YANG ◽

QING-HAI HUANG ◽

JIAN-MIN LIU

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Cfd Simulation ◽

Patient Specific ◽

Parent Artery ◽

Cross Sectional ◽

3D Angiography ◽

Cross Section Area ◽

Increased Risk ◽

Risk Of Rupture

To identify hemodynamic and morphological parameters leading to increased risk of intracranial fusiform aneurysms (IFA) rupture using computational fluid dynamics (CFDs). A total of 24 patient-specific fusiform aneurysms models on vertebral artery were reconstructed from 3D angiography images. 11 ruptured cases and 13 unruptured cases were included. Morphologic parameters were measured and CFD parameters were calculated using CFD simulation. The length of the aneurysm is significantly shorter in ruptured group than in unruptured group. The ratio of the width to the length of an aneurysm (WLR) and the ratio of the cross-section area to the length of an aneurysm (ALR) to the averaged cross sectional areas of the inlet and outlet of the parent artery (ALaR) were significantly higher in ruptured group compared with unruptured group. Wall shear stress (WSS) of the aneurysm was normalized to the WSS of the parent artery. Hemodynamically, only low WSS was associated with higher risk of rupture. Ruptured IFAs are shorter, have bigger WLR, ALaR, and lower WSS, compared with unruptured IFAs.

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