scholarly journals The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model

2018 ◽  
Vol 11 (5) ◽  
pp. 419-433 ◽  
Author(s):  
Harpinder Saini ◽  
Kiarash Rahmani Eliato ◽  
Casey Silva ◽  
Mayar Allam ◽  
Ghassan Mouneimne ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Tumor Model ◽  
Cancer Drug ◽  
Stromal Fibroblasts ◽  
Cancer Drug Resistance ◽  
Anti Cancer

scholarly journals The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance

2021 ◽  
Author(s):  
Jihye Seo ◽  
Jain Ha ◽  
Eunjeong Kang ◽  
Sayeon Cho
Keyword(s):  
Drug Resistance ◽  
Transcription Factors ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Drug ◽  
Preclinical Studies ◽  
Mesenchymal Transition ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Future Challenges

AbstractThe complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key roles in metastasis. They are also highlighted in recent preclinical studies on resistance to cancer therapy. This review describes the role of three main EMT-TFs, including Snail, Twist1, and zinc-finger E homeobox-binding 1 (ZEB1), relating to drug resistance and current possible approaches for future challenges targeting EMT-TFs.

scholarly journals The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

2012 ◽  
Vol 106 (12) ◽  
pp. 1901-1906 ◽  
Author(s):  
J M Houthuijzen ◽  
L G M Daenen ◽  
J M L Roodhart ◽  
E E Voest
Keyword(s):  
Stem Cells ◽  
Drug Resistance ◽  
Mesenchymal Stem Cells ◽  
Tumour Progression ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Anti Cancer

scholarly journals The role of glutathione-S-transferase in anti-cancer drug resistance

Oncogene ◽  
2003 ◽  
Vol 22 (47) ◽  
pp. 7369-7375 ◽  
Author(s):  
Danyelle M Townsend ◽  
Kenneth D Tew
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Glutathione S Transferase ◽  
Cancer Drug Resistance ◽  
Anti Cancer

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance

2020 ◽  
Vol 20 (9) ◽  
pp. 779-787
Author(s):  
Kajal Ghosal ◽  
Christian Agatemor ◽  
Richard I. Han ◽  
Amy T. Ku ◽  
Sabu Thomas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Repair ◽  
Fanconi Anemia ◽  
Cancer Drug ◽  
Drug Resistant ◽  
Cancer Drugs ◽  
Repair Pathway ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Cancerous Cells

Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance arises from different mechanistic pathways, and in this critical review, we focus on the Fanconi Anemia (FA) pathway in chemoresistance. This pathway has yet to be intensively researched by mainstream cancer researchers. This review aims to inspire a new thrust toward the contribution of the FA pathway to drug resistance in cancer. We believe an indepth understanding of this pathway will open new frontiers to effectively treat drug-resistant cancer.

scholarly journals Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

2018 ◽  
Vol 20 (1) ◽  
pp. 51 ◽  
Author(s):  
Yoojung Kwon ◽  
Youngmi Kim ◽  
Hyun Jung ◽  
Dooil Jeoung
Keyword(s):  
Molecular Networks ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Angiogenic Potential ◽  
Histone Deacetylase 3 ◽  
Cancer Drug Resistance ◽  
Tumorigenic Potential ◽  
Anti Cancer ◽  
Cancer Testis

Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed.

scholarly journals Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives

2012 ◽  
Vol 4 (8) ◽  
pp. 675-684 ◽  
Author(s):  
Nicholas A. Saunders ◽  
Fiona Simpson ◽  
Erik W. Thompson ◽  
Michelle M. Hill ◽  
Liliana Endo‐Munoz ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Cancer Drug Resistance ◽  
Intratumoural Heterogeneity

scholarly journals Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance

2012 ◽  
Vol 83 (8) ◽  
pp. 1084-1103 ◽  
Author(s):  
Karthika Natarajan ◽  
Yi Xie ◽  
Maria R. Baer ◽  
Douglas D. Ross
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Breast Cancer Resistance Protein ◽  
Cancer Drug ◽  
Cancer Resistance ◽  
Cancer Drug Resistance ◽  
Resistance Protein

Editorial (Thematic Issue: Signalling Pathways in Anti-cancer Drug Resistance)

2014 ◽  
Vol 21 (26) ◽  
pp. 3007-3008 ◽  
Author(s):  
Chen Chen ◽  
Jiezhong Chen ◽  
Kong-Nan Zhao
Keyword(s):  
Drug Resistance ◽  
Thematic Issue ◽  
Cancer Drug ◽  
Signalling Pathways ◽  
Cancer Drug Resistance ◽  
Anti Cancer
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