A Gel-Free Reservoir System for Once-a-Day Ophthalmic Delivery of Timolol Maleate

2021 ◽  
Author(s):  
Arindam Halder ◽  
Malay D. Shah ◽  
Bharat Pateliya ◽  
Vinod Burade ◽  
Ajay J. Khopade
Keyword(s):  
Timolol Maleate ◽  
Reservoir System ◽  
Ophthalmic Delivery

scholarly journals Crosslinking-Dependent Drug Kinetics in Hydrogels for Ophthalmic Delivery

Polymers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 248
Author(s):  
Nicole Mortensen ◽  
Parker Toews ◽  
Jeffrey Bates
Keyword(s):  
Release Kinetics ◽  
Crosslinking Density ◽  
Tetraethylene Glycol ◽  
Hydroxyethyl Methacrylate ◽  
Diffusion Kinetics ◽  
Timolol Maleate ◽  
Drug Diffusion ◽  
Kinetics Studies ◽  
Ophthalmic Delivery ◽  
The Relationship

Drug-diffusion kinetics in 2-hydroxyethyl methacrylate hydrogels were studied as a function of the crosslinking density and porosity. By varying the concentration of the crosslinker, tetraethylene glycol dimethacrylate, we demonstrated how the release of Timolol maleate could be optimized to allow for efficient drug delivery. FTIR and spectrophotometry supplied optical inferences into the functional groups present. By studying the swelling and degradation of hydrogels, supplemented with drug-release kinetics studies, the relationship between these two tenets could be formulated.

Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

2020 ◽  
Vol 13 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Srividya Gorantla ◽  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Stimuli Responsive ◽  
Duration Of Action ◽  
Age Related ◽  
Aqueous Gels ◽  
Ophthalmic Delivery ◽  
3D Printed

Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

Single tuned algorithm to estimate the SPM concentration in a cascade reservoir system using OLI/L8 images

2020 ◽  
Vol 66 (11) ◽  
pp. 2583-2596
Author(s):  
Nariane Bernardo ◽  
Alisson Carmo ◽  
Luiz Rotta ◽  
Enner Alcântara
Keyword(s):  
Reservoir System ◽  
Spm Concentration

scholarly journals Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 444
Author(s):  
Alaa Mahran ◽  
Sayed Ismail ◽  
Ayat A. Allam
Keyword(s):  
Triamcinolone Acetonide ◽  
Delivery System ◽  
Histopathological Examination ◽  
Rabbit Model ◽  
Subconjunctival Injection ◽  
In Vivo Evaluation ◽  
Ternary Phase Diagrams ◽  
Ophthalmic Delivery

Treatment of uveitis (i.e., inflammation of the uvea) is challenging due to lack of convenient ophthalmic dosage forms. This work is aimed to determine the efficiency of triamcinolone acetonide (TA)-loaded microemulsion as an ophthalmic delivery system for the treatment of uveitis. Water titration method was used to construct different pseudo-ternary phase diagrams. Twelve microemulsion formulations were prepared using oleic acid, Cremophor EL, and propylene glycol. Among all tested formulations, Formulation F3, composed of oil: surfactant-co-surfactant (1:1): water (15:35:50% w/w, respectively), was found to be stable and showed acceptable pH, viscosity, conductivity, droplet size (211 ± 1.4 nm), and zeta potential (−25 ± 1.7 mV) and almost complete in vitro drug release within 24 h. The in vivo performance of the optimized formulation was evaluated in experimentally uveitis-induced rabbit model and compared with a commercial TA suspension (i.e., Kenacort®-A) either topically or by subconjunctival injection. Ocular inflammation was evaluated by clinical examination, white blood cell count, protein content measurement, and histopathological examination. The developed TA-loaded microemulsion showed superior therapeutic efficiency in the treatment of uveitis with high patient compliance compared to commercial suspension. Hence, it could be considered as a potential ocular treatment option in controlling of uveitis.

Spark-based parallel dynamic programming and particle swarm optimization via cloud computing for a large-scale reservoir system

2021 ◽  
pp. 126444
Author(s):  
Yufei Ma ◽  
Ping-an Zhong ◽  
Bin Xu ◽  
Feilin Zhu ◽  
Qingwen Lu ◽  
...  
Keyword(s):  
Cloud Computing ◽  
Dynamic Programming ◽  
Particle Swarm Optimization ◽  
Large Scale ◽  
Particle Swarm ◽  
Swarm Optimization ◽  
Reservoir System
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