Simple Peripheral Blood Cell Parameters: Neutrophil/Lymphocyte, Platelet/Lymphocyte and Monocyte/Lymphocyte Ratios Do Not Determine Breast Cancer Subtypes

AbstractThe aim of the present study was to evaluate the association between changes in peripheral blood cell count and neopterin concentrations in patients with a history of breast cancer. Peripheral blood cell count, serum ferritin, serum neopterin and urinary neopterin concentrations were determined in 61 patients with a history of breast cancer and 74 control subjects. Hemoglobin, relative lymphocyte count and absolute lymphocyte count were lower, and relative neutrophil count, ferritin and serum neopterin concentrations were significantly higher in breast cancer patients than in controls. Compared to controls, the difference in hemoglobin concentration was statistically significant only in patients with active disease. Significant negative correlations were observed between urinary neopterin and hemoglobin as well as between serum neopterin and relative lymphocyte counts in breast cancer patients. Increased ferritin concentrations were associated with a history of hypertension, but higher absolute lymphocyte counts were associated with hypertension only in subjects without history of cancer. In conclusion, in patients with a history of breast cancer, anemia is associated with disease activity and systemic immune activation. Ferritin concentrations are increased in subjects with hypertension.

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Epigenetic alterations in peripheral blood cell DNA and implications for breast cancer detection, prognosis, and treatment.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.e13619 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. e13619-e13619

Author(s):

B. Torres-Torres ◽

J. Martínez-Galán ◽

R. Del Moral ◽

M. Núñez ◽

B. González-Astorga ◽

...

Keyword(s):

Breast Cancer ◽

Blood Cell ◽

Cancer Detection ◽

Peripheral Blood ◽

Peripheral Blood Cell ◽

Breast Cancer Detection ◽

Epigenetic Alterations

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Explore the Predictive Value of Peripheral Blood Cell Parameters in Refractory Mycoplasma pneumoniae Pneumonia in Children Over 6 Years Old

Frontiers in Pediatrics ◽

10.3389/fped.2021.659677 ◽

2021 ◽

Vol 9 ◽

Author(s):

Yaoyao Ling ◽

Jing Ning ◽

Yongsheng Xu

Keyword(s):

Pleural Effusion ◽

Blood Cell ◽

Mycoplasma Pneumoniae ◽

Peripheral Blood ◽

Predictive Value ◽

Fiberoptic Bronchoscopy ◽

Peripheral Blood Cell ◽

Binary Logistic Regression Analysis ◽

Cell Parameters ◽

Lymphocyte Ratio

Background: To determine the predictive value of peripheral blood cell parameters for refractory Mycoplasma pneumoniae pneumonia (RMPP) in children over 6 years old.Methods: A retrospective study was conducted in children with RMPP admitted to the respiratory department of Tianjin Children's Hospital from September 2017 to September 2019, and non-refractory Mycoplasma pneumoniae pneumonia (NRMPP) was selected by the propensity score method and matched according to the ratio of 1:1.5. We analyzed the differences in clinical characteristics, peripheral blood cell parameters, imaging findings, and treatments between the two groups, and further determined the predictive value of peripheral blood cell parameters on RMPP.Results: There were 76 patients in the RMPP group and 114 patients in the NRMPP group. We found that the RMPP group has a longer clinical course and a higher incidence of intrapulmonary and extrapulmonary complications (p < 0.01). Moreover, the proportion of children in the RMPP group who received immunotherapy (such as glucocorticoid, gamma immunoglobulin) and fiberoptic bronchoscopy intervention was higher than that in the NRMPP group (p < 0.01). Meanwhile, the level of neutrophil, neutrophil/lymphocyte ratio (NLR), platelet count/lymphocyte ratio (PLR), mean platelet volume/lymphocyte ratio (MPVLR), C-reactive protein (CRP), lactic dehydrogenase (LDH), and interleukin (IL)-6 in the RMPP group was significantly higher (p < 0.01) than those in the NRMPP group. The incidence of pulmonary consolidation, atelectasis, and pleural effusion was also higher in the RMPP group (p < 0.05). ROC curve and binary logistic regression analysis showed that NLR > 3.92 (OR = 3.243; 95% CI = 1.485–7.081; p = 0.003), MPVLR > 5.29 (OR = 2.700; 95% CI = 1.258–5.795; p = 0.011), and pleural effusion (OR = 3.023; 95% CI = 1.424–6.420; p = 0.004) were significant factors in predicting RMPP. Our study showed that NLR had higher accuracy in predicting RMPP than CRP.Conclusions: The parameters of peripheral blood cells might be a predictor of RMPP. NLR > 3.92, MPVLR > 5.29, and pleural effusion might have important predictive value for RMPP in children over 6 years old.

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Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

10.1101/551465 ◽

2019 ◽

Author(s):

Chang Ik Yoon ◽

So Eun Park ◽

Yoon Jin Cha ◽

Soong June Bae ◽

Chi Hwan Cha ◽

...

Keyword(s):

Breast Cancer ◽

Blood Cell ◽

Peripheral Blood ◽

Immune Cell ◽

Laboratory Data ◽

Peripheral Blood Cell ◽

Cell Mediated Immunity ◽

Breast Cancer Patients ◽

Cell Counts ◽

Blood Cell Counts

AbstractTumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. We aimed to investigate whether peripheral blood cell counts are associated with TILs in breast cancer. Between August 2016 and July 2018, we evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥ 50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data. Of the 684 patients, 99 (17.2%) had LPBC, and 478 (82.8%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,330 vs. 3,660; P=0.004), but the other means were not different. Decreasing ANC was an independent clinical factor in predicting LPBC (OR: 0.736, 95% CI: 0.591-0.917; P=0.004). Low peripheral ANC might be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.

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