scholarly journals Therapeutic effect of microencapsulated porcine retinal pigmented epithelial cells transplantation on rat model of Parkinson’s disease

2007 ◽  
Vol 23 (3) ◽  
pp. 137-144 ◽  
Author(s):  
Hou-Liang Zhang ◽  
Jian-Jun Wu ◽  
Hui-Min Ren ◽  
Jian Wang ◽  
Ya-Ru Su ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Epithelial Cells ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Retinal Pigmented Epithelial Cells

Neuroprotective and Therapeutic Effect of Caffeine on the Rat Model of Parkinson's Disease Induced by Rotenone

2017 ◽  
Vol 14 (5) ◽  
pp. 553-572 ◽  
Author(s):  
Yasser A. Khadrawy ◽  
Ahmed M. Salem ◽  
Karima A. El-Shamy ◽  
Emad K. Ahmed ◽  
Nevein N. Fadl ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Effect ◽  
Rat Model

scholarly journals Therapeutic Effect of Hydrogen Sulfide-Releasing L-Dopa Derivative ACS84 on 6-OHDA-Induced Parkinson’s Disease Rat Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60200 ◽  
Author(s):  
Li Xie ◽  
Li-Fang Hu ◽  
Xing Qi Teo ◽  
Chi Xin Tiong ◽  
Valerio Tazzari ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Hydrogen Sulfide ◽  
Therapeutic Effect ◽  
Rat Model

P4-179: Therapeutic effect of ACS84 on Parkinson's disease in 6-OHDA-induced rat model

2011 ◽  
Vol 7 ◽  
pp. S766-S766
Author(s):  
Li Xie ◽  
Chi Xin Tiong ◽  
Jinsong Bian
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Therapeutic Effect ◽  
Rat Model

scholarly journals Assessment of Neuroprotective Effects of Low-Intensity Transcranial Ultrasound Stimulation in a Parkinson’s Disease Rat Model by Fractional Anisotropy and Relaxation Time T2∗ Value

2021 ◽  
Vol 15 ◽  
Author(s):  
Yanchao Dong ◽  
Defeng Liu ◽  
Yuemei Zhao ◽  
Yi Yuan ◽  
Wenxi Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Relaxation Time ◽  
Fractional Anisotropy ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Transcranial Ultrasound ◽  
Therapeutic Effects ◽  
Neuroprotective Effects ◽  
Low Intensity

Background: Low-intensity transcranial ultrasound (LITUS) may have a therapeutic effect on Parkinson’s disease (PD) patients to some extent. Fractional anisotropy (FA) and relaxation time T2∗ that indicate the integrity of fiber tracts and iron concentrations in brain tissue have been used to evaluate the therapeutic effects of LITUS.Purpose: This study aims to use FA and T2∗ values to evaluate the therapeutic effects of LITUS in a PD rat model.Materials and Methods: Twenty Sprague-Dawley rats were randomly divided into a hemi-PD group (n = 10) and a LITUS group (n = 10). Single-shot spin echo echo-planar imaging and fast low-angle shot T2WI sequences at 3.0 T were used. The FA and T2∗ values on the right side of the substantia nigra (SN) pars compacta were measured to evaluate the therapeutic effect of LITUS in the rats.Results: One week after PD-like signs were induced in the rats, the FA value in the LITUS group was significantly larger compared with the PD group (0.214 ± 0.027 vs. 0.340 ± 0.032, t = 2.864, P = 0.011). At the 5th and 6th weeks, the FA values in the LITUS group were significantly smaller compared with the PD group (5th week: 0.290 ± 0.037 vs. 0.405 ± 0.027, t = 2.385, P = 0.030; 6th week: 0.299 ± 0.021 vs. 0.525 ± 0.028, t = 6.620, P < 0.0001). In the 5th and 6th weeks, the T2∗ values in the injected right SN of the LITUS group were significantly higher compared with the PD group (5th week, 12.169 ± 0.826 in the LITUS group vs. 7.550 ± 0.824 in the PD group; 6th week, 11.749 ± 0.615 in the LITUS group vs. 7.550 ± 0.849 in the PD group).Conclusion: LITUS had neuroprotective effects and can reduce the damage of 6-OHDA-induced neurotoxicity in hemi-PD rats. The combination of FA and T2∗ assessments can potentially serve as a new and effective method to evaluate the therapeutic effects of LITUS.

In vivo multimodal (MRI, SPECT) imaging of the 6-OHDA rat model for Parkinson's disease correlated with behavior and histology

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S392-S392
Author(s):  
Nadja Van Camp ◽  
Koen Van Laere ◽  
Ruth Vreys ◽  
Marleen Verhoye ◽  
Erwin Lauwers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Spect Imaging ◽  
Multimodal Mri
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