Neue Klasse von Methyltransferasen mit Zyklisierungsaktivität

AbstractMicroorganisms release small volatile metabolites with unique structures, e. g. the polymethylated homosesquiterpene sodorifen from Serratia plymuthica. Two unusual enzymes with novel features are involved in its biosynthesis, a C-methyltransferase with cyclization activity and a terpene synthase that accepts a non-canonical monocyclic C16 substrate. The novel class of methyltransferases represents an alternative route that enlarges terpene diversity.

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Analyzing the impact of SARS CoV-2 on the human proteome

10.1101/2020.05.21.107912 ◽

2020 ◽

Author(s):

Ernesto Estrada

Keyword(s):

Cerebral Cortex ◽

Alternative Route ◽

Human Tissues ◽

The Novel ◽

Ppi Network ◽

Protein Protein Interaction ◽

Organ Level ◽

Novel Coronavirus ◽

Diffusive Processes ◽

The Impact

AbstractThe COVID-19 respiratory disease is caused by the novel coronavirus SARS-CoV-2, which uses the enzyme ACE2 to entry human cells. This disease is characterized by important damages at multi-organ level, partially due to the abundant expression of ACE2 in practically all human tissues. However, not every organ in which ACE2 is abundant is affected by SARS CoV-2, which suggests the existence of other multi-organ routes for transmitting the perturbations produced by the virus. We consider here diffusive processes through the protein-protein interaction (PPI) network of proteins targeted by SARS CoV-2 as such alternative route. We found a subdiffusive regime that allows the propagation of virus perturbations through the PPI network at a significant rate. By following the main subdiffusive routes across the PPI network we identify proteins mainly expressed in the heart, cerebral cortex, thymus, testis, lymph node, kidney, among others of the organs reported to be affected by COVID-19.

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Derek Robinson. 27 May 1941 — 2 December 2002

Biographical Memoirs of Fellows of the Royal Society ◽

10.1098/rsbm.2011.0012 ◽

2011 ◽

Vol 57 ◽

pp. 395-422 ◽

Cited By ~ 1

Author(s):

John Connor ◽

Colin Windsor

Keyword(s):

Lung Cancer ◽

Laser Light ◽

Strong Support ◽

Thomson Scattering ◽

Spherical Tokamak ◽

Alternative Route ◽

The Novel ◽

Fusion Power ◽

Research Activities ◽

Early Success

Derek Robinson was a leading UK plasma physicist of his generation. After an early success in measuring the electron temperature in the ZETA plasma through the Thomson scattering of laser light, he became a key member of the team from Culham Laboratory sent to Moscow in 1968 to verify the high temperatures claimed by the Russians for their T3 tokamak. On returning to Culham his research activities continued to broaden and he became an acknowledged expert on a range of fusion devices. His management responsibilities grew in parallel and eventually he became Director of Culham. With his strong support, Culham explored the novel spherical tokamak devices START and MAST, and he promoted this concept as an alternative route to the conventional tokamak for developing fusion power. His energetic leadership and his mastery of theory, experiment and fusion politics brought fusion power nearer to reality. His vision of the ‘way forward’ for the international fusion programme remains with us after his life was so sadly cut short by the unexpected development of lung cancer in a non-smoker.

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Deep Learning-Based Hardness Prediction of Novel Refractory High-Entropy Alloys with Experimental Validation

Crystals ◽

10.3390/cryst11010046 ◽

2021 ◽

Vol 11 (1) ◽

pp. 46

Author(s):

Uttam Bhandari ◽

Congyan Zhang ◽

Congyuan Zeng ◽

Shengmin Guo ◽

Aashish Adhikari ◽

...

Keyword(s):

Neural Network ◽

Deep Learning ◽

Experimental Validation ◽

Essential Property ◽

High Entropy Alloys ◽

Alternative Route ◽

The Novel ◽

High Entropy ◽

Hardness Prediction ◽

First Time

Hardness is an essential property in the design of refractory high entropy alloys (RHEAs). This study shows how a neural network (NN) model can be used to predict the hardness of a RHEA, for the first time. We predicted the hardness of several alloys, including the novel C0.1Cr3Mo11.9Nb20Re15Ta30W20 using the NN model. The hardness predicted from the NN model was consistent with the available experimental results. The NN model prediction of C0.1Cr3Mo11.9Nb20Re15Ta30W20 was verified by experimentally synthesizing and investigating its microstructure properties and hardness. This model provides an alternative route to determine the Vickers hardness of RHEAs.

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A Terpene Synthase Is Involved in the Synthesis of the Volatile Organic Compound Sodorifen of Serratia plymuthica 4Rx13

Frontiers in Microbiology ◽

10.3389/fmicb.2016.00737 ◽

2016 ◽

Vol 7 ◽

Cited By ~ 13

Author(s):

Dajana Domik ◽

Andrea Thürmer ◽

Teresa Weise ◽

Wolfgang Brandt ◽

Rolf Daniel ◽

...

Keyword(s):

Organic Compound ◽

Volatile Organic Compound ◽

Terpene Synthase ◽

Serratia Plymuthica ◽

Volatile Organic

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The reaction of ethenetetracarbonitrile with acyclic β-dicarbonyl compounds and related studies

Australian Journal of Chemistry ◽

10.1071/ch9731551 ◽

1973 ◽

Vol 26 (7) ◽

pp. 1551 ◽

Cited By ~ 16

Author(s):

JW Ducker ◽

MJ Gunter

Keyword(s):

Carboxylic Acids ◽

Alternative Route ◽

The Novel ◽

Dicarbonyl Compounds

The reaction of ethenetetracarbonitrile (TCNE) with acyclic β- dicarbonyl compounds has been shown to give 2-dicyanomethylene-2,5- dihydropyrroles (5) via 2-imino-2,3-dihydrofurans (4). Hydrogenation of (5) gave the pyrroles (16). Representative pyrroles were degraded and synthesized by an alternative route. The novel transformation of substituted malononitriles to carboxylic acids has been investigated. The reaction of alcohols with ketone-ethenetetracarbonitrile adducts has been reinvestigated.

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