The effect of geometric layout of exit on escape mechanism of crowd

AbstractImmunotherapy has become a powerful cancer treatment, but only a small fraction of patients have achieved durable benefits due to the immune escape mechanism. In this study, epigenetic regulation is combined with gene therapy-mediated immune checkpoint blockade to relieve this immune escape mechanism. PPD (i.e., mPEG-b-PLG/PEI-RT3/DNA) is developed to mediate plasmid-encoding shPD-L1 delivery by introducing multiple interactions (i.e., electrostatic, hydrogen bonding, and hydrophobic interactions) and polyproline II (PPII)-helix conformation, which downregulates PD-L1 expression on tumour cells to relieve the immunosuppression of T cells. Zebularine (abbreviated as Zeb), a DNA methyltransferase inhibitor (DNMTi), is used for the epigenetic regulation of the tumour immune microenvironment, thus inducing DC maturation and MHC I molecule expression to enhance antigen presentation. PPD plus Zeb combination therapy initiates a systemic anti-tumour immune response and effectively prevents tumour relapse and metastasis by generating durable immune memory. This strategy provides a scheme for tumour treatment and the inhibition of relapse and metastasis.

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PENENTUAN LOKASI TOWER CRANE PADA PROYEK KONSTRUKSI BERBASIS SIMULASI

JMTS: Jurnal Mitra Teknik Sipil ◽

10.24912/jmts.v3i4.8694 ◽

2020 ◽

Vol 3 (4) ◽

pp. 1305

Author(s):

Gerwyn Persulessy ◽

Basuki Anondho

Keyword(s):

Travel Time ◽

Construction Projects ◽

Tower Crane ◽

Location Determination ◽

Heavy Equipment ◽

Total Travel Time ◽

Speed Up ◽

High Level ◽

Map Data ◽

Geometric Layout

Development of high-level building construction projects that require complex equipment that can be used in high-level construction, equipment used to help complete construction projects called heavy equipment. One of the heavy equipment used in high-rise buildings is a tower crane. The use and layout of tower cranes can speed up the schedule and save on project costs. Therefore many methods have been developed to determine the tower crane layout. This study will discuss determining the location of tower cranes by discussing simulations. The location will be determined based on the site map data which is processed in the form of a geometric arrangement and tower crane data specifications. Location determination is done by comparing the total travel time of several simulated locations according to several different speed criteria in a construction project. Speed criteria are divided into four times the jib speed and trolley speed. Location of the location with the total travel time will be taken as the final result. Different speed criteria will make the total travel time change. ABSTRAKPerkembangan proyek pembangunan gedung bertingkat tinggi yang semakin kompleks menyebabkan diperlukannya peralatan yang dapat mempermudah pembangunan gedung bertingkat, peralatan yang digunakan untuk membantu menyelesaikan tugas konstruksi disebut alat berat. Salah satu peralatan berat yang digunakan pada gedung bertingkat tinggi adalah tower crane. Penggunaan dan tata letak tower crane yang baik dapat mempercepat jadwal dan menghemat biaya proyek. Oleh karena itu banyak dikembangkan metode-metode untuk menentukan tata letak tower crane. Penelitian ini akan membahas penetapan letak lokasi tower crane dengan pendekatan simulasi. Letak lokasi akan ditetapkan berdasarkan data site map yang diolah dalam bentuk geometric layout dan data spesifikasi tower crane. Penetapan lokasi dilakukan dengan cara membandingkan total travel time dari beberapa lokasi yang disimulasi sesuai dengan beberapa kriteria kecepatan yang berbeda-beda pada suatu proyek konstruksi. Kriteria kecepatan terbagi menjadi empat berdasarkan besarnya kecepatan jib dan kecepatan trolley. Letak lokasi dengan total travel time terkecil akan diambil sebagai hasil akhir. Kriteria-kriteria kecepatan yang berbeda disimulasi akan membuat total travel time berubah.

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