Targeting Heat Shock Proteins 60 and 70 of Toxoplasma gondii as a Potential Drug Target: In Silico Approach

2015 ◽  
Vol 8 (4) ◽  
pp. 374-387 ◽  
Author(s):  
Kaur Ashwinder ◽  
Mee Teck Kho ◽  
Phui Mun Chee ◽  
Wui Zhuan Lim ◽  
Ivan K. S. Yap ◽  
...  
Keyword(s):  
Heat Shock ◽  
Toxoplasma Gondii ◽  
Heat Shock Proteins ◽  
In Silico ◽  
Drug Target ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Shock Proteins

scholarly journals Structural and functional diversity in the family of small heat shock proteins from the parasite Toxoplasma gondii

2009 ◽  
Vol 1793 (11) ◽  
pp. 1738-1748 ◽  
Author(s):  
Natalia de Miguel ◽  
Nathalie Braun ◽  
Alexander Bepperling ◽  
Thomas Kriehuber ◽  
Andreas Kastenmüller ◽  
...  
Keyword(s):  
Heat Shock ◽  
Toxoplasma Gondii ◽  
Heat Shock Proteins ◽  
Functional Diversity ◽  
Small Heat Shock Proteins ◽  
The Family ◽  
Shock Proteins

Surface proteins, potential drug target for antiviral therapy against Nipah virus and in silico drug design

2011 ◽  
Vol 44 (13) ◽  
pp. S34 ◽  
Author(s):  
Rafiqur Rahman ◽  
S.M. Mahbubbur Rashid ◽  
Manzur Sayeem ◽  
Istiaq Sharif ◽  
Kawsar Sharif
Keyword(s):  
Drug Design ◽  
Antiviral Therapy ◽  
In Silico ◽  
Drug Target ◽  
Nipah Virus ◽  
Surface Proteins ◽  
Potential Drug Target ◽  
Potential Drug ◽  
In Silico Drug Design

Heat shock protein 90 as a potential drug target against surra

Parasitology ◽  
2014 ◽  
Vol 141 (9) ◽  
pp. 1148-1155 ◽  
Author(s):  
ANKIT K. ROCHANI ◽  
CHANDAN MITHRA ◽  
MEETALI SINGH ◽  
UTPAL TATU
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Drug Target ◽  
Animal Health ◽  
Heat Shock Protein 90 ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Priority List ◽  
Animal Populations ◽  
Animal Trypanosomiasis

SUMMARYTrypanosomiasis is caused by Trypanosoma species which affect both human and animal populations and pose a major threat to developing countries. The incidence of animal trypanosomiasis is on the rise. Surra is a type of animal trypanosomiasis, caused by Trypanosoma evansi, and has been included in priority list B of significant diseases by the World Organization of Animal Health (OIE). Control of surra has been a challenge due to the lack of effective drugs and vaccines and emergence of resistance towards existing drugs. Our laboratory has previously implicated Heat shock protein 90 (Hsp90) from protozoan parasites as a potential drug target and successfully demonstrated efficacy of an Hsp90 inhibitor in cell culture as well as a pre-clinical mouse model of trypanosomiasis. This article explores the role of Hsp90 in the Trypanosoma life cycle and its potential as a drug target. It appears plausible that the repertoire of Hsp90 inhibitors available in academia and industry may have value for treatment of surra and other animal trypanosomiasis.

Heat shock proteins of Toxoplasma gondii

1995 ◽  
Vol 17 (7) ◽  
pp. 353-359 ◽  
Author(s):  
R.E. LYONS ◽  
A.M. JOHNSON
Keyword(s):  
Heat Shock ◽  
Toxoplasma Gondii ◽  
Heat Shock Proteins ◽  
Shock Proteins

scholarly journals A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information

2009 ◽  
Vol 104 (8) ◽  
pp. 1100-1110 ◽  
Author(s):  
Marcelo Alves-Ferreira ◽  
Ana Carolina Ramos Guimarães ◽  
Priscila Vanessa da Silva Zabala Capriles ◽  
Laurent E Dardenne ◽  
Wim M Degrave
Keyword(s):  
Pathway Analysis ◽  
Metabolic Pathway ◽  
In Silico ◽  
Drug Target ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Metabolic Pathway Analysis ◽  
Drug Target Discovery ◽  
New Approach ◽  
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