Social discrimination and college enrollment: findings from the China family panel studies

Author(s):  
Jiafeng Gu ◽  
Xing Ming
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Renad Jabarin ◽  
Nina Levy ◽  
Yasmin Abergel ◽  
Joshua H. Berman ◽  
Amir Zag ◽  
...  

AbstractIn this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in glutamatergic synapses and mutations in the IQSEC2 gene are a frequent cause of neurodevelopmental disorders. We have recently reported on the molecular pathophysiology of one such mutation A350V and demonstrated that this mutation downregulates AMPA type glutamatergic receptors (AMPAR) in A350V mice. Here we sought to identify behavioral deficits in A350V mice and hypothesized that we could rescue these deficits by PF-4778574, a positive AMPAR modulator. Using a battery of social behavioral tasks, we found that A350V Iqsec2 mice exhibit specific deficits in sex preference and emotional state preference behaviors as well as in vocalizations when encountering a female mouse. The social discrimination deficits, but not the impaired vocalization, were rescued with a single dose of PF-4778574. We conclude that social behavior deficits associated with the A350V Iqsec2 mutation may be rescued by enhancing AMPAR mediated synaptic transmission.


2021 ◽  
Vol 13 (7) ◽  
pp. 3983
Author(s):  
Gheorghe-Gavrilă Hognogi ◽  
Ana-Maria Pop ◽  
Alexandra-Camelia Marian-Potra

Marginal settlements may be defined as inhabited areas characterized by a series of negative features, typicallyethnic segregation, social discrimination, poor living conditions and conflicts, with impact on their dwellers and neighboring communities. In Romania, informal settlements were legislated in 2019; it subsequently became mandatory for the local authorities to spatially delimit them and formulate measures to improve living conditions. However, there are still numerous issues to be solved, from the lack of basic services (health, education) to the persistent poor living conditions or serious environmental problems. The Roma communities selected for our study are no exception. They are located on the outskirts of some cities or in their historical centers (Cluj-Napoca, Sibiu, Timișoara, Baia Mare). Through content analysis, based on print and electronic media from the last 10 years (n = 150 news items), different aspects of marginal housing were illustrated. The results of the study revealed some particular aspects, namely: some of the Roma communities are relocated whilst some others are subject to environmental conflicts; funding addressing the quality of life of Roma ethnics seems to deepen the phenomenon of segregation among communities, most of the measures being limited to the creation of housing facilities.


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