Green Synthesis of Silver Nanoparticles by Plumbago indica and Its Antitumor Activity Against Dalton's Lymphoma Ascites Model

ABSTRACTObjective: Tabernaemontana divaricata (Td) is commonly used plants for the treatment of inflammatory, anticancer, and diabetics. The main objectiveof this study is to assess the antitumor and antioxidant activity of Td in mice model.Methods: Antitumor activity of TdPf extract (52 µg/ml) is evaluated against Dalton’s lymphoma ascites (DLA) tumor mice. After 24 hrs of tumorinoculation, the extract is administered daily for 15 and 60 days. After administration of the lost dose followed by 18 hrs fasting, mice are sacrificedfor observation of antitumor activity. Antitumor activity is assessed by monitoring the liver marker enzyme, lipid peroxidation effect on antioxidantenzyme levels, and histopathological evidence.Results: The results showed that the protein extract of Td animals restored the antioxidant enzymes when compared to the mice of the DLA controlgroup.Conclusion: The findings indicate that the extract of plant protein has antitumor activity by preventing the lipid peroxidation and thereby promotingthe antioxidant systems in DLA induced mice. And hence, it is evident that these extract could be a natural anticancer agent for the human health.Keywords: Dalton’s lymphoma ascites, Antitumor, Tabernaemontana divaricata, Lipid peroxidation antioxidant.

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ANTITUMOR POTENTIAL OF HYDROETHANOLIC EXTRACT OF ANNONA MURICATA LEAVES AGAINST DALTON’S LYMPHOMA ASCITES-INDUCED TUMOR IN MICE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i3.22807 ◽

2018 ◽

Vol 11 (3) ◽

pp. 364 ◽

Cited By ~ 1

Author(s):

Nalini P ◽

Brindha Durairaj

Keyword(s):

Body Weight ◽

Antitumor Activity ◽

The Body ◽

Dependent Manner ◽

Annona Muricata ◽

Antitumor Potential ◽

Dalton’S Lymphoma ◽

Dalton's Lymphoma ◽

Hematological And Biochemical Parameters ◽

Hydroethanolic Extract

Objective: The objective of this study was to assess the antitumor activity of hydroethanolic extract of Annona muricata (HEEAM) in Dalton’s lymphoma ascites (DLA)-induced tumor model.Methods: Antitumor activity of HEEAM was evaluated against DLA-induced tumor mice by assessing the antitumor, hematological, and biochemical parameters.Results: The results revealed that antitumor activity of HEEAM was observed in Swiss albino mice at the doses of 200 and 400 mg/kg body weight given orally for 15 days. The results indicated that administration of the extracts not only increased the survival of animals and decreased the body weight with ascites tumor but also altered many hematological and biochemical parameters. Both extracts exhibited a significant (p<0.05) antitumor activity on dose-dependent manner. Among the two doses, 400 mg/kg of HEEAM dose showed potent anticancer activity.Conclusion: The findings confirmed that the HEEAM possess potent antitumor activity, and hence, it might be used as a natural anticancer agent

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