scholarly journals Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes

2016 ◽  
Vol 7 (4) ◽  
pp. 248-260 ◽  
Author(s):  
Adviye Ergul ◽  
Sherif Hafez ◽  
Abdelrahman Fouda ◽  
Susan C. Fagan
2021 ◽  
Vol 91 ◽  
pp. 649-667 ◽  
Author(s):  
Damien Levard ◽  
Izaskun Buendia ◽  
Anastasia Lanquetin ◽  
Martina Glavan ◽  
Denis Vivien ◽  
...  

Author(s):  
Faridatus Soleha

This study aims to describe the feelings of the characters in the novel Juang Notes by Fiersa Bersari and researchers analyze using personality theory originated by Ludwig Klages by focusing his study on the personality structure of feelings. Feeling is a process of someone accepting or rejecting something in life. This study uses a qualitative approach by using library techniques to obtain data that will produce a description of the words or sentences in the observed study. In the analysis of this research using the hermeutics technique, in the hermeutics technique there are several stages, namely reading the research object in this study in the form of a fighting journal, the second gives a mark on the data that has been obtained from the reading results, the third provides code or coding on the data that has been found, and the fourth is to analyze data that has been obtained from the object of research in accordance with the specified research focus. Novel Notes Juang by Fiersa Besari is a novel that can be used as an inspiration for readers in living life. Based on the results of the study it was found that in the Fighting Notes novel there is a feeling that is divided into inner activities and the level of clarity, inner activities in the novel in the form of fear and guilt while viewed from the level of clarity in the form of happiness, sadness and longing.


Author(s):  
S.A. Kirillina

Abstract The culmination of long-term development of the traditional pilgrimage genre in Russian literature falls on the eighteenth century. Reports of Russian pilgrims to the Christian Holy Places of the Middle East produced during this period, not only precede the nineteenth century the Golden age of travel literature in Russia, but also retain their great historical and cultural significance and still remain a subject of research for scholars dwelling on the Arab-Ottoman history. The authors attention is focused on 12 pilgrims accounts written by Ivan Lukjanov (dates of travel: 17011703), Makariy and Seliverst (17041707), Andrey Ignatiev (17071708), Ippolit Vishenskiy (17071709), Varlaam (17121714), Matvey Nechaev (17211722), Sylvester and Nicodim (1722), Vasiliy Grigorowich-Barskiy (17231747), Serapion (17491751), Ignatiy Denshin (17661776), Leontiy (17631765) and Meletiy (17931794). The research focus of the article is on the personalities of the pilgrimagewriters, their biographical data and social background as well as the fates of their writings after their completion. Some of the pilgrims accounts received due credit long after they had been produced, others gained great popularity at the time of writing and some of them were almost forgotten and mostly neglected by scholars of the following generations. The article also deals with the religious affiliation of the pilgrimage-writers, which predetermined their perception of the Arab-Ottoman world through the prism of Russian Orthodoxy and the values preached by this particular brand of Christianity.Аннотация В XVIII в. традиционный паломнический жанр в русской словесности достиг подлинного расцвета и подошел к своему логическому завершению. Паломнические описания Святой Земли, составленные в XVIII в., не только предваряют XIX столетие золотой век путешествий в русской литературе, но и сохраняют свою самостоятельную историко-культурную значимость, а их содержательная сторона продолжает оставаться объектом исследований ученых, в том числе арабистов и османистов. Внимание автора сосредоточено на 12 паломнических описаниях, авторство которых принадлежит Ивану Лукьянову (даты путешествия: 17011703 гг.), Макарию и Селиверсту (17041707 гг.), Андрею Игнатьеву (17071708 гг.), Ипполиту Вишенскому (17071709 гг.), Варлааму (17121714 гг.), Матвею Нечаеву (17211722 гг.), Сильвестру и Никодиму (1722 г.), Василию Григоровичу-Барскому (17231747 гг.), Серапиону (17491751 гг.), Игнатию Деншину (17661776 гг.), Леонтию (17631765 гг.) и Мелетию (17931794 гг.). В исследовательском фокусе статьи находятся личности паломников и дошедшие до нас сведения об их биографиях, их социальное происхождение, а также последующая судьба их произведений. Одни письменные свидетельства богомольцев о хождениях к святым местам Ближнего Востока завоевали признание современников, другие были по достоинству оценены значительно позднее, а некоторые практически выпали из поля зрения последующих поколений исследователей. В статье также отдельно рассмотрена конфессиональная принадлежность паломников-писателей, которая предопределила их восприятие арабо-османского мира сквозь призму Русского Православия.


2020 ◽  
Vol 13 ◽  
Author(s):  
Kun Xiao ◽  
Fei Zhao ◽  
WenJie Xie ◽  
Jian Ding ◽  
XiaoAn Gong ◽  
...  

Objective: To explore and investigate the molecular mechanism of TLR4 mediated T cell immune effect in transfusion-induced acute injury based on SLIT2/ROBO4 signaling pathway. Methods: Sixty C57/BL6 male mice (Wild type, WT) aged 8 to 10 weeks were randomly divided into 5 groups: 1) normal type WT, 2) LPS control group of WT type lipopolysaccharide, 3) WT type TRALI group (LPS + MHC-I mAb), 4) (TLR4 antibody) lipopolysaccharide LPS control group, 5) (TLR4 antibody) TRALI group (LPS + MHC-I mAb). Mice were dosed with LPS (0.1 mg / kg), and MHC-I mAb (2 mg / kg) was injected into the tail vein 24 hours later for modeling. After 2 hours, mice were sacrificed and experimental samples were collected. HE staining was performed to detect pathological features. The myeloperoxidase (MPO) activity and the level of IL-2, IL-6, TNF, IFN-γ, IL-17A as well as IL-10 were measured in the lung tissue homogenate supernatant. Blood, spleen single cell suspension and bronchoalveolar lavage fluid (BALF) were collected to detect the ratio of Treg and Th17 cells by flow cytometry, respectively. RT-PCR and WB indicated the mRNA or protein expression of CDH5 (Cadherin-5), SLIT2 and ROBO4 in mouse lung tissue and pulmonary vascular tissue respectively. Results: TLR4 mAb treatment decreases the pathological features of LPS induced ALI model in vivo. And so does the MPO activity as well as the level of proinflammatory factors in the lung tissue. TLR4 exerts its function through the changes of Treg/Th17 ratio via SLIT2/ROBO4 signaling pathway and downregulating CDH5 and SETSIP in ALI model. Conclusion: TLR4 mediates immune response in LPS induced ALI model through SLIT2/ROBO4 signaling pathway.


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