Neural Stem Cells Therapy for Ischemic Stroke: Progress and Challenges

2022 ◽  
Author(s):  
Tong Zhao ◽  
Tongming Zhu ◽  
Liqian Xie ◽  
Yao Li ◽  
Rong Xie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Stem Cells Therapy

scholarly journals Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats

2016 ◽  
Vol 13 (2) ◽  
pp. 645-650 ◽  
Author(s):  
Li Luo ◽  
Kaihua Guo ◽  
Wenguo Fan ◽  
Yinghong Lu ◽  
Lizhi Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Neuronal Differentiation

scholarly journals In Vivo Targeted MR Imaging of Endogenous Neural Stem Cells in Ischemic Stroke

Molecules ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1143 ◽  
Author(s):  
Fang Zhang ◽  
Xiaohui Duan ◽  
Liejing Lu ◽  
Xiang Zhang ◽  
Xiaomei Zhong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Mr Imaging ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

scholarly journals Novel Therapeutic Transplantation of Induced Neural Stem Cells for Stroke

2017 ◽  
Vol 26 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Toru Yamashita ◽  
Wentao Liu ◽  
Yoshiaki Matsumura ◽  
Ryosuke Miyagi ◽  
Yun Zhai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Artery Occlusion ◽  
Neural Cells ◽  
Ipsilateral Striatum ◽  
Therapeutic Transplantation ◽  
Induced Neural Stem Cells ◽  
Cerebral Artery Occlusion ◽  
Transplantation Therapy

Somatic cells can be directly converted into induced neural stem cells (iNSCs) by defined transcription factors. However, the therapeutic effect of undifferentiated iNSCs on ischemic stroke has not been demonstrated. In this study, we used a mouse model of transient middle cerebral artery occlusion (tMCAO). iNSCs (5 × 105) were injected directly into the ipsilateral striatum and cortex 24 h after tMCAO. Histological analysis was performed at 7 days, 28 days, and 8 months after tMCAO. We found that iNSC transplantation successfully improved the survival rate of stroke model mice with significant functional recovery from the stroke. The fate of engrafted iNSCs was that the majority of iNSCs had differentiated into astroglial cells but not into neural cells in both the sham-operated brain and the poststroke brain without forming a tumor up to 8 months after tMCAO. Our data suggest that the directly converted iNSCs can be regarded as a candidate of safe cell resource for transplantation therapy in patients suffering from ischemic stroke.

scholarly journals BDNF Pretreatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery after Transplantation in Hypoxic–Ischemic Stroke

2015 ◽  
Vol 24 (12) ◽  
pp. 2449-2461 ◽  
Author(s):  
Sahar Rosenblum ◽  
Tenille N. Smith ◽  
Nancy Wang ◽  
Joshua Y. Chua ◽  
Erick Westbroek ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Cell Survival ◽  
Functional Recovery

scholarly journals Effects of primary microglia and astrocytes on neural stem cells in in vitro and in vivo models of ischemic stroke

2021 ◽  
Vol 16 (9) ◽  
pp. 1677
Author(s):  
Qiong-Lan Yuan ◽  
Sheng-Jun Wen ◽  
Xi-Min Zheng ◽  
Li-Fen Liu ◽  
Na-Na Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Primary Microglia ◽  
In Vivo Models

Neural Stem Cells Transfected with Reactive Oxygen Species-Responsive Polyplexes for Effective Treatment of Ischemic Stroke

2019 ◽  
Vol 31 (10) ◽  
pp. 1807591 ◽  
Author(s):  
Xin-Chi Jiang ◽  
Jia-Jia Xiang ◽  
Hong-Hui Wu ◽  
Tian-Yuan Zhang ◽  
Dan-Ping Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Effective Treatment ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Intra-arterial stem cells therapy activates BDNF-TrkB signaling pathway to improve post-stroke outcome in senescent rodent model of ischemic stroke

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S367-S368
Author(s):  
Pallab Bhattacharya ◽  
Deepaneeta Sarmah ◽  
Harpreet Kaur ◽  
Dileep Yavagal
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Signaling Pathway ◽  
Rodent Model ◽  
Stroke Outcome ◽  
Post Stroke ◽  
Stem Cells Therapy

scholarly journals Exosomes derived from human neural stem cells stimulated by interferon gamma improve therapeutic ability in ischemic stroke model

2020 ◽  
Vol 24 ◽  
pp. 435-445 ◽  
Author(s):  
Guilong Zhang ◽  
Zhihan Zhu ◽  
Hong Wang ◽  
Yongbo Yu ◽  
Wanghao Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Interferon Gamma ◽  
Stroke Model ◽  
Human Neural Stem Cells

Migration of neural stem cells to ischemic brain regions in ischemic stroke in rats

2013 ◽  
Vol 552 ◽  
pp. 124-128 ◽  
Author(s):  
Jiong Dai ◽  
Shan-Quan Li ◽  
Yong-Ming Qiu ◽  
Wen-Hao Xiong ◽  
Yu-Hua Yin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Brain Regions ◽  
Ischemic Brain
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