Migration of neural stem cells to ischemic brain regions in ischemic stroke in rats

2013 ◽  
Vol 552 ◽  
pp. 124-128 ◽  
Author(s):  
Jiong Dai ◽  
Shan-Quan Li ◽  
Yong-Ming Qiu ◽  
Wen-Hao Xiong ◽  
Yu-Hua Yin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Brain Regions ◽  
Ischemic Brain

scholarly journals In Vivo Targeted MR Imaging of Endogenous Neural Stem Cells in Ischemic Stroke

Molecules ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1143 ◽  
Author(s):  
Fang Zhang ◽  
Xiaohui Duan ◽  
Liejing Lu ◽  
Xiang Zhang ◽  
Xiaomei Zhong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Mr Imaging ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

scholarly journals Novel Therapeutic Transplantation of Induced Neural Stem Cells for Stroke

2017 ◽  
Vol 26 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Toru Yamashita ◽  
Wentao Liu ◽  
Yoshiaki Matsumura ◽  
Ryosuke Miyagi ◽  
Yun Zhai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Artery Occlusion ◽  
Neural Cells ◽  
Ipsilateral Striatum ◽  
Therapeutic Transplantation ◽  
Induced Neural Stem Cells ◽  
Cerebral Artery Occlusion ◽  
Transplantation Therapy

Somatic cells can be directly converted into induced neural stem cells (iNSCs) by defined transcription factors. However, the therapeutic effect of undifferentiated iNSCs on ischemic stroke has not been demonstrated. In this study, we used a mouse model of transient middle cerebral artery occlusion (tMCAO). iNSCs (5 × 105) were injected directly into the ipsilateral striatum and cortex 24 h after tMCAO. Histological analysis was performed at 7 days, 28 days, and 8 months after tMCAO. We found that iNSC transplantation successfully improved the survival rate of stroke model mice with significant functional recovery from the stroke. The fate of engrafted iNSCs was that the majority of iNSCs had differentiated into astroglial cells but not into neural cells in both the sham-operated brain and the poststroke brain without forming a tumor up to 8 months after tMCAO. Our data suggest that the directly converted iNSCs can be regarded as a candidate of safe cell resource for transplantation therapy in patients suffering from ischemic stroke.

scholarly journals Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis

2019 ◽  
Vol 20 (10) ◽  
pp. 2574 ◽  
Author(s):  
Annabella Benedek ◽  
Daniel Cernica ◽  
Andras Mester ◽  
Diana Opincariu ◽  
Roxana Hodas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Shear Stress ◽  
Ischemic Stroke ◽  
Therapeutic Angiogenesis ◽  
Current Status ◽  
Regenerative Therapy ◽  
Therapeutic Approaches ◽  
Ischemic Brain ◽  
Promising Tool ◽  
3D Geometry

Ischemic stroke is associated with a tremendous economic and societal burden, and only a few therapies are currently available for the treatment of this devastating disease. The main therapeutic approaches used nowadays for the treatment of ischemic brain injury aim to achieve reperfusion, neuroprotection and neurorecovery. Therapeutic angiogenesis also seems to represent a promising tool to improve the prognosis of cerebral ischemia. This review aims to present the modern concepts and the current status of regenerative therapy for ischemic stroke and discuss the main results of major clinical trials addressing the effectiveness of stem cell therapy for achieving neuroregeneration in ischemic stroke. At the same time, as a glimpse into the future, this article describes modern concepts for stroke prevention, such as the implantation of bioprinted scaffolds seeded with stem cells, whose 3D geometry is customized according to carotid shear stress.

scholarly journals BDNF Pretreatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery after Transplantation in Hypoxic–Ischemic Stroke

2015 ◽  
Vol 24 (12) ◽  
pp. 2449-2461 ◽  
Author(s):  
Sahar Rosenblum ◽  
Tenille N. Smith ◽  
Nancy Wang ◽  
Joshua Y. Chua ◽  
Erick Westbroek ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Cell Survival ◽  
Functional Recovery

scholarly journals Effects of primary microglia and astrocytes on neural stem cells in in vitro and in vivo models of ischemic stroke

2021 ◽  
Vol 16 (9) ◽  
pp. 1677
Author(s):  
Qiong-Lan Yuan ◽  
Sheng-Jun Wen ◽  
Xi-Min Zheng ◽  
Li-Fen Liu ◽  
Na-Na Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Primary Microglia ◽  
In Vivo Models
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