Oleic acid decreases the expression of a cholesterol transport-related protein (NPC1L1) by the induction of endoplasmic reticulum stress in CaCo-2 cells

2010 ◽  
Vol 67 (2) ◽  
pp. 153-163 ◽  
Author(s):  
Jiangyuan Chen ◽  
Qi Li ◽  
Ying Zhang ◽  
Pu Yang ◽  
Yiqiang Zong ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Oleic Acid ◽  
Endoplasmic Reticulum Stress ◽  
Cholesterol Transport ◽  
Related Protein

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection

2015 ◽  
Vol 80 ◽  
pp. 298-309 ◽  
Author(s):  
Virginia Pardo ◽  
Águeda González-Rodríguez ◽  
Jordi Muntané ◽  
Sara C. Kozma ◽  
Ángela M. Valverde
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Oleic Acid ◽  
Endoplasmic Reticulum Stress ◽  
Palmitic Acid

scholarly journals NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153

2006 ◽  
Vol 96 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Maiko Awai ◽  
Takahisa Koga ◽  
Yasuya Inomata ◽  
Seiichi Oyadomari ◽  
Tomomi Gotoh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Related Protein ◽  
Retinal Injury

scholarly journals C1q/TNF-Related Protein 9 Protects Diabetic Rat Heart against Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Sanxing Bai ◽  
Liang Cheng ◽  
Yang Yang ◽  
Chongxi Fan ◽  
Dajun Zhao ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Heart Function ◽  
Ischemia Reperfusion ◽  
Diabetic Heart ◽  
Diabetic Rat ◽  
H9c2 Cells ◽  
Related Protein ◽  
Lactate Dehydrogenase Activity

As a newly identified adiponectin paralog, C1q/TNF-related protein 9 (CTRP9) reduces myocardial ischemia reperfusion (IR) injury through partially understood mechanisms. In the present study, we sought to identify the role of endoplasmic reticulum stress (ERS) in CTRP9 induced cardioprotection in diabetic heart. Isolated hearts from high-fat-diet (HFD) induced type 2 diabetic Sprague-Dawley rats were subjected to ex vivo IR protocol via a Langendorff apparatus at the presence of globular CTRP9. CTRP9 significantly improved post-IR heart function and reduced cardiac infarction, cardiomyocytes apoptosis, Caspase-3, Caspase-9, Caspase-12, TNF-αexpression, and lactate dehydrogenase activity. The cardioprotective effect of CTRP9 was associated with reduced ERS and increased expression of disulfide-bond A oxidoreductase-like protein (DsbA-L) in diabetic heart. CTRP9 reduced ERS in thapsigargin (TG) treated cardiomyocytes and protected endoplasmic reticulum (ER) stressed H9c2 cells against simulated ischemia reperfusion (SIR) injury, concurrent with increased expression of DsbA-L. Knockdown of DsbA-L increased ERS and attenuated CTRP9 induced protection against SIR injury in H9c2 cells. Our findings demonstrated for the first time that CTRP9 exerts cardioprotection by reducing ERS in diabetic heart through increasing DsbA-L.

Ghrelin ameliorates acute lung injury induced by oleic acid via inhibition of endoplasmic reticulum stress

Life Sciences ◽  
2018 ◽  
Vol 196 ◽  
pp. 1-8 ◽  
Author(s):  
Xiuli Tian ◽  
Zhijun Liu ◽  
Ting Yu ◽  
Haitao Yang ◽  
Linlin Feng
Keyword(s):  
Endoplasmic Reticulum ◽  
Acute Lung Injury ◽  
Oleic Acid ◽  
Lung Injury ◽  
Endoplasmic Reticulum Stress
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