scholarly journals Over-expression of NOTCH1 as a biomarker for invasive breast ductal carcinoma

3 Biotech ◽  
2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mahdi Paryan ◽  
Rezvan Tavakoli ◽  
Seyed Mohammad Ali Hosseini Rad ◽  
Neda Feizi ◽  
Fereshteh Kamani ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Over Expression ◽  
Invasive Breast Ductal Carcinoma

Abstract B14: Sprouty4 regulates the transition to invasive breast ductal carcinoma through ERK/MAPK signaling

2018 ◽  
Author(s):  
Ethan J. Brock ◽  
Ryan Jackson ◽  
Julie L. Boerner ◽  
Quanwen Li ◽  
Bonnie F. Sloane ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Mapk Signaling ◽  
Erk Mapk ◽  
Invasive Breast Ductal Carcinoma

The prognostic significance of infiltrating immune cells subtypes in invasive ductal carcinoma of the breast.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23177-e23177
Author(s):  
Qiuhong Zheng
Keyword(s):  
Immune Cell ◽  
Ductal Carcinoma ◽  
Primary Tumour ◽  
Prognostic Significance ◽  
Cancer Prognosis ◽  
Invasive Ductal Breast Carcinoma ◽  
Kaplan Meier ◽  
Immune Cell Subsets ◽  
The Mean ◽  
Invasive Breast Ductal Carcinoma

e23177 Background: To explore the correlation between tumour infiltrating immune cell subsets and breast cancer prognosis. Methods: Specimens of 102 patients with invasive breast ductal carcinoma were analyzed for immune -related markers (CD8, CD20, FoxP3 and CD68). The number of positive cells in 3 most highly-stained intratumoural stroma areas of the primary tumour was counted. The mean number of each marker was calculated and used to divide patients into two groups respectively (CD8high/CD8low group, CD20high/CD20low group, FOXP3high/ FOXP3 low group and CD68high/CD68 low group). Results: Kaplan–Meier survival analysis showed : (A) For all patients, high tumour-infiltrating CD8+ and CD20+ B lymphocytes , low tumour-infiltrating FoxP3+ Treg and CD68+ macrophages all increased the OS and DFS (P < 0.05); (B) For both the 35 ER negative and the 45 lymphonode negative patients, high CD8+ CTLs increased the OS and DFS(P < 0.05). Multivariate analysis of OS and DFS showed for all patients, high CD8+ CTLs and low FoxP3+ Treg were related to good OS and DFS(P < 0.05). Conclusions: high number of tumour-infiltrating CD8 and low FoxP3 T lymphocytes both could function as potential independent prognostic markers for invasive ductal breast carcinoma .

scholarly journals Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Galasso ◽  
Giorgio Costantino ◽  
Lorenzo Pasquali ◽  
Linda Minotti ◽  
Federica Baldassari ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Circular Rnas ◽  
Next Generation ◽  
Genomic Context ◽  
Functional Roles ◽  
In Situ Carcinoma ◽  
The Common ◽  
Generation Sequencing ◽  
Invasive Breast Ductal Carcinoma

The recent advantage obtained by next generation sequencing allows a depth investigation of a new “old” kind of noncoding transcript, the circular RNAs. Circular RNAs are nontranslated RNAs, typically nonpolyadenylated, with a resistance to exonucleases that gives them the ability to be more stable than the common linear RNA isoforms. We used a bioinformatic detection tool (CIRCexplorer) to research predictive circRNAs from the next generation sequenced data of five samples of ductal in situ carcinoma (DCIS) and matched adjacent invasive ductal carcinoma (IDC). Furthermore, we also investigated the circular RNAs expressed in MCF7, an invasive breast ductal carcinoma cell line. We described the genomic context of the predicted circular RNAs and we address the hypothetical possible functional roles. This study showed a perspective of a panel of predictive circRNAs identified and the function that circRNAs could exert.

DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma

2005 ◽  
Vol 59 ◽  
pp. S363-S365 ◽  
Author(s):  
E.L.H. Lui ◽  
W.T.Y. Loo ◽  
L. Zhu ◽  
M.N.B. Cheung ◽  
L.W.C. Chow
Keyword(s):  
Ductal Carcinoma ◽  
Dna Hypermethylation ◽  
Invasive Breast Ductal Carcinoma
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