Expression of Sema4D in invasive breast ductal carcinoma, NOS in relation to tumour angiogenesis and tumour-associated macrophages

2016 ◽  
Author(s):  
Ewe Seng Ch´ng
Keyword(s):  
Ductal Carcinoma ◽  
Tumour Angiogenesis ◽  
Invasive Breast Ductal Carcinoma

Abstract B14: Sprouty4 regulates the transition to invasive breast ductal carcinoma through ERK/MAPK signaling

2018 ◽  
Author(s):  
Ethan J. Brock ◽  
Ryan Jackson ◽  
Julie L. Boerner ◽  
Quanwen Li ◽  
Bonnie F. Sloane ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Mapk Signaling ◽  
Erk Mapk ◽  
Invasive Breast Ductal Carcinoma

The prognostic significance of infiltrating immune cells subtypes in invasive ductal carcinoma of the breast.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23177-e23177
Author(s):  
Qiuhong Zheng
Keyword(s):  
Immune Cell ◽  
Ductal Carcinoma ◽  
Primary Tumour ◽  
Prognostic Significance ◽  
Cancer Prognosis ◽  
Invasive Ductal Breast Carcinoma ◽  
Kaplan Meier ◽  
Immune Cell Subsets ◽  
The Mean ◽  
Invasive Breast Ductal Carcinoma

e23177 Background: To explore the correlation between tumour infiltrating immune cell subsets and breast cancer prognosis. Methods: Specimens of 102 patients with invasive breast ductal carcinoma were analyzed for immune -related markers (CD8, CD20, FoxP3 and CD68). The number of positive cells in 3 most highly-stained intratumoural stroma areas of the primary tumour was counted. The mean number of each marker was calculated and used to divide patients into two groups respectively (CD8high/CD8low group, CD20high/CD20low group, FOXP3high/ FOXP3 low group and CD68high/CD68 low group). Results: Kaplan–Meier survival analysis showed : (A) For all patients, high tumour-infiltrating CD8+ and CD20+ B lymphocytes , low tumour-infiltrating FoxP3+ Treg and CD68+ macrophages all increased the OS and DFS (P < 0.05); (B) For both the 35 ER negative and the 45 lymphonode negative patients, high CD8+ CTLs increased the OS and DFS(P < 0.05). Multivariate analysis of OS and DFS showed for all patients, high CD8+ CTLs and low FoxP3+ Treg were related to good OS and DFS(P < 0.05). Conclusions: high number of tumour-infiltrating CD8 and low FoxP3 T lymphocytes both could function as potential independent prognostic markers for invasive ductal breast carcinoma .

Early changes in angiogenesis and hypoxia following bevacizumab therapy in primary breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1066-1066
Author(s):  
Shaveta Mehta ◽  
Nicholas Peter Hughes ◽  
Adrian M. Jubb ◽  
Helen Turley ◽  
Chen Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Ductal Carcinoma ◽  
Locally Advanced Breast Cancer ◽  
Single Agent ◽  
Locally Advanced ◽  
Rank Test ◽  
Tumour Hypoxia ◽  
Tumour Angiogenesis ◽  
Dce Mri

1066 Background: Bevacizumab (BV), a monoclonal antibody directed against vascular endothelial growth factor (VEGF), is an approved anti-angiogenic agent, but despite its widespread use, little is known about how tumours develop resistance to BV. We have conducted a window-of-opportunity study in which BV is administered as a short-term first-line treatment for primary breast cancer (PBC) patients, and assessed histological markers of tumour angiogenesis and hypoxia before and after therapy. Methods: 47 patients with locally advanced breast cancer were prospectively enrolled. Informed consent was obtained from all patients. A single infusion of BV (15 mg/kg) was given 2 weeks before starting neoadjuvant chemotherapy. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and core biopsies for immunohistochemistry (IHC) analysis were performed immediately prior to and 2 weeks after BV. 36 patients with invasive ductal carcinoma and good quality MRI scans and core biopsies were included in this analysis. Wilcoxon rank test and Spearman’s correlation test were used for statistical analysis. Results: IHC revealed a significant upregulation of carbonic anhydrase 9 (P = 0.04) and hypoxia inducible factor-1a (P = 0.001) following BV therapy along with a significant reduction in plasmalemma vesicle associated protein (PLVAP) (p=0.01) and Ki67 (p= 0.006). DCE-MRI analysis revealed a significant reduction in vessel permeability and blood flow following BV, as measured by a decrease in the forward transfer constant Ktrans (P < 0.0001) and the reverse rate constant kep (P < 0.0001). In addition, we found a significant negative correlation between CA9 levels and median Ktrans at baseline (Spearman’s rho = -0.46; P = 0.01). Conclusions: Using combined DCE-MRI and IHC analysis, we found that PBC patients treated with single-agent BV showed a decrease in markers of tumour angiogenesis, together with a corresponding increase in tumour hypoxia. Our results suggest that tumour hypoxia may be a key mechanism governing the early onset of resistance to BV therapy, and argue for the use of suitable combination therapies to overcome the resistance and ultimately improve patient survival.

scholarly journals Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Galasso ◽  
Giorgio Costantino ◽  
Lorenzo Pasquali ◽  
Linda Minotti ◽  
Federica Baldassari ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Circular Rnas ◽  
Next Generation ◽  
Genomic Context ◽  
Functional Roles ◽  
In Situ Carcinoma ◽  
The Common ◽  
Generation Sequencing ◽  
Invasive Breast Ductal Carcinoma

The recent advantage obtained by next generation sequencing allows a depth investigation of a new “old” kind of noncoding transcript, the circular RNAs. Circular RNAs are nontranslated RNAs, typically nonpolyadenylated, with a resistance to exonucleases that gives them the ability to be more stable than the common linear RNA isoforms. We used a bioinformatic detection tool (CIRCexplorer) to research predictive circRNAs from the next generation sequenced data of five samples of ductal in situ carcinoma (DCIS) and matched adjacent invasive ductal carcinoma (IDC). Furthermore, we also investigated the circular RNAs expressed in MCF7, an invasive breast ductal carcinoma cell line. We described the genomic context of the predicted circular RNAs and we address the hypothetical possible functional roles. This study showed a perspective of a panel of predictive circRNAs identified and the function that circRNAs could exert.

DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma

2005 ◽  
Vol 59 ◽  
pp. S363-S365 ◽  
Author(s):  
E.L.H. Lui ◽  
W.T.Y. Loo ◽  
L. Zhu ◽  
M.N.B. Cheung ◽  
L.W.C. Chow
Keyword(s):  
Ductal Carcinoma ◽  
Dna Hypermethylation ◽  
Invasive Breast Ductal Carcinoma

scholarly journals Diagnosis, treatment, and outcomes of encapsulated papillary carcinoma: a single institution experience

2018 ◽  
Vol 25 (2) ◽  
pp. 66-75 ◽  
Author(s):  
Laura Steponavičienė ◽  
Daiva Gudavičienė ◽  
Rūta Briedienė ◽  
Donatas Petroška ◽  
Aušra Garnelytė
Keyword(s):  
Breast Cancer ◽  
Papillary Carcinoma ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Single Institution ◽  
Treatment Data ◽  
Pathology Reports ◽  
Evidence Based Guidelines ◽  
Invasive Breast Ductal Carcinoma

Background. Encapsulated papillary carcinoma (EPC) is a rare entity of breast cancer accounting for approximately 1–2% of all breast tumours. There are no evidence-based guidelines for the treatment of EPC. Materials and methods. From the database of the National Centre of Pathology (NCP), we obtained pathology reports of 19 patients with histologically confirmed EPC, who were treated at the National Cancer Institute (NCI) in Vilnius, Lithuania, between July 2009 and July 2015. Demographic, diagnostic and treatment data were collected from medical records retrospectively. Results. During the indicated period, 19 patients with EPC were treated at the NCI. Three of them had pure EPC, they were 74 to 81 years of age at the time of diagnosis (mean 76.7 years, median 75 years); all of them are still alive and no disease progression has been observed. Seven patients had EPC associated with carcinoma in situ. Nine patients had EPC associated with invasive breast ductal carcinoma. All patients underwent surgery, in most cases – wide local excision. Only one patient died. Conclusions. EPC is a rare form of breast cancer and usually presents with an invasive breast carcinoma or carcinoma in situ in postmenopausal women. Tumours have an excellent prognosis in the cases of pure EPC and in both EPC associated with carcinoma in situ (CIS) and invasive carcinoma.

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