Gene expression profiles of human neuroblastoma cells exposed to CuO nanoparticles and Cu ions

2016 ◽  
Vol 10 (2) ◽  
pp. 140-149 ◽  
Author(s):  
Seok-Won Jang ◽  
Min-Su Oh ◽  
Sung Ik Yang ◽  
Eun-Min Cho
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Neuroblastoma Cells ◽  
Gene Expression Profiles ◽  
Cuo Nanoparticles ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Cu Ions

Microarray analysis of gene expression profiles in human neuroblastoma cells exposed to Aβ–Zn and Aβ–Cu complexes

2012 ◽  
Vol 7 (4) ◽  
pp. 483-497
Author(s):  
Valentina Gatta ◽  
Alberto Granzotto ◽  
Karina Fincati ◽  
Denise Drago ◽  
Silvia Bolognin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Microarray Analysis ◽  
Expression Profiles ◽  
Neuroblastoma Cells ◽  
Gene Expression Profiles ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Cu Complexes

scholarly journals Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Chantal Hoi Yin Cheung ◽  
Chia-Lang Hsu ◽  
Chao-Yin Tsuei ◽  
Tzu-Ting Kuo ◽  
Chen-Tsung Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Cancer Progression ◽  
Expression Profiles ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cells ◽  
Gene Expression Profiles ◽  
Migration Ability ◽  
Purine Synthesis ◽  
One Carbon Metabolism

Abstract MYCN-amplified (MNA) neuroblastoma is an aggressive neural crest-derived pediatric cancer. However, MYCN is indispensable for development and transcriptionally regulates extensive network of genes. Integrating anti-MYCN ChIP-seq and gene expression profiles of neuroblastoma patients revealed the metabolic enzymes, MTHFD2 and PAICS, required for one-carbon metabolism and purine biosynthesis were concomitantly upregulated, which were more susceptible to metastatic neuroblastoma. Moreover, we found that MYCN mediated the folate cycle via MTHFD2, which contributed one-carbon unit to enhance purine synthesis, and further regulated nucleotide production by PAICS in response to cancer progression. Dual knockdown of the MYCN-targeted gene pair, MTHFD2 and PAICS, in MNA neuroblastoma cells synergically reduced cell proliferation, colony formation, migration ability, and DNA synthesis. By systematically screening the compound perturbagens, the gene expression levels of MTHFD2 and PAICS were specifically suppressed by anisomycin and apicidin across cell lines, and our co-treatment results also displayed synergistic inhibition of MNA neuroblastoma cell proliferation. Collectively, targeting a combination of MYCN-targeted genes that interrupts the interconnection of metabolic pathways may overcome drug toxicity and improve the efficacy of current therapeutic agents in MNA neuroblastoma.

scholarly journals The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182984 ◽  
Author(s):  
How-Wing Leung ◽  
Gabriel Foo ◽  
Gokulakrishna Banumurthy ◽  
Xiaoran Chai ◽  
Sujoy Ghosh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroblastoma Cells ◽  
Bacopa Monnieri ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Expression Levels ◽  
Gene Expression Levels

Radiofrequency radiation (900 MHz) induces Egr-1 gene expression and affects cell-cycle control in human neuroblastoma cells

2007 ◽  
Vol 213 (3) ◽  
pp. 759-767 ◽  
Author(s):  
M. Buttiglione ◽  
L. Roca ◽  
E. Montemurno ◽  
F. Vitiello ◽  
V. Capozzi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Cell Cycle Control ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Radiofrequency Radiation

Human GAP-43 Gene Expression: Multiple Start Sites for Initiation of Transcription in Differentiating Human Neuroblastoma Cells

1993 ◽  
Vol 4 (6) ◽  
pp. 549-561 ◽  
Author(s):  
Eva Örtoft ◽  
Sven Påhlman ◽  
Göran Andersson ◽  
Vendela Parrow ◽  
Christer Betsholtz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Initiation Of Transcription

Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain

2010 ◽  
Vol 40 (3) ◽  
pp. 634-644 ◽  
Author(s):  
Barbara Fazi ◽  
Michela Biancolella ◽  
Bisan Mehdawy ◽  
Marco Corazzari ◽  
Daniela Minella ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma
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