Radiofrequency radiation (900 MHz) induces Egr-1 gene expression and affects cell-cycle control in human neuroblastoma cells

2007 ◽  
Vol 213 (3) ◽  
pp. 759-767 ◽  
Author(s):  
M. Buttiglione ◽  
L. Roca ◽  
E. Montemurno ◽  
F. Vitiello ◽  
V. Capozzi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Cell Cycle Control ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Radiofrequency Radiation

scholarly journals Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest

2018 ◽  
Vol 19 (9) ◽  
pp. 2832 ◽  
Author(s):  
Jae-Sun Choi ◽  
Jaewook Ryu ◽  
Woom-Yee Bae ◽  
Aron Park ◽  
Seungyoon Nam ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cyclin D1 ◽  
Molecular Mechanisms ◽  
Neuroblastoma Cells ◽  
Mitotic Arrest ◽  
Therapeutic Drug ◽  
Mouse Tumor ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Mitotic Cells

Cancer cells undergo uncontrolled proliferation resulting from aberrant activity of various cell-cycle proteins. Therefore, despite recent advances in intensive chemotherapy, it is difficult to cure cancer completely. Recently, cell-cycle regulators became attractive targets in cancer therapy. Zingerone, a phenolic compound isolated from ginger, is a nontoxic and inexpensive compound with varied pharmacological activities. In this study, the therapeutic effect of zingerone as an anti-mitotic agent in human neuroblastoma cells was investigated. Following treatment of BE(2)-M17 cells with zingerone, we performed a 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay and colony-formation assay to evaluate cellular proliferation, in addition to immunofluorescence cytochemistry and flow cytometry to examine the mitotic cells. The association of gene expression with tumor stage and survival was analyzed. Furthermore, to examine the anti-cancer effect of zingerone, we applied a BALB/c mouse-tumor model using a BALB/c-derived adenocarcinoma cell line. In human neuroblastoma cells, zingerone inhibited cellular viability and survival. Moreover, the number of mitotic cells, particularly those in prometaphase, increased in zingerone-treated neuroblastoma cells. Regarding specific molecular mechanisms, zingerone decreased cyclin D1 expression and induced the cleavage of caspase-3 and poly (ADP-ribose) polymerase 1 (PARP-1). The decrease in cyclin D1 and increase in histone H3 phosphorylated (p)-Ser10 were confirmed by immunohistochemistry in tumor tissues administered with zingerone. These results suggest that zingerone induces mitotic arrest followed by inhibition of growth of neuroblastoma cells. Collectively, zingerone may be a potential therapeutic drug for human cancers, including neuroblastoma.

scholarly journals Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

Oncogene ◽  
2005 ◽  
Vol 24 (36) ◽  
pp. 5606-5618 ◽  
Author(s):  
Christopher J Wallick ◽  
Ivonne Gamper ◽  
Mike Thorne ◽  
David J Feith ◽  
Kelsie Y Takasaki ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Neuroblastoma Cells ◽  
Retinoblastoma Protein ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182984 ◽  
Author(s):  
How-Wing Leung ◽  
Gabriel Foo ◽  
Gokulakrishna Banumurthy ◽  
Xiaoran Chai ◽  
Sujoy Ghosh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroblastoma Cells ◽  
Bacopa Monnieri ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Expression Levels ◽  
Gene Expression Levels

scholarly journals Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO

2008 ◽  
Vol 7 (5) ◽  
pp. 709-717 ◽  
Author(s):  
Jennifer Alabran ◽  
Adam Cheuk ◽  
Karen Liby ◽  
Michael Sporn ◽  
Javed Khan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Cycle Arrest ◽  
Derivatives Of

Human GAP-43 Gene Expression: Multiple Start Sites for Initiation of Transcription in Differentiating Human Neuroblastoma Cells

1993 ◽  
Vol 4 (6) ◽  
pp. 549-561 ◽  
Author(s):  
Eva Örtoft ◽  
Sven Påhlman ◽  
Göran Andersson ◽  
Vendela Parrow ◽  
Christer Betsholtz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Initiation Of Transcription
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