scholarly journals Low-dose chloroquine treatment extends the lifespan of aged rats

2022 ◽  
Author(s):  
Wei Li ◽  
Zhiran Zou ◽  
Yusheng Cai ◽  
Kuan Yang ◽  
Si Wang ◽  
...  
Keyword(s):  
Low Dose ◽  
Aged Rats ◽  
Chloroquine Treatment

scholarly journals Safety and Efficacy of Ketamine-Fentanyl-Dexmedetomidine-Induced Anesthesia and Analgesia in Neonatal and Aged Rats

Dose-Response ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 155932582110639
Author(s):  
Xuhui Zhou ◽  
Wenlong Li ◽  
Hao Wang ◽  
Chunzhu Li ◽  
Hong Jiang
Keyword(s):  
Low Dose ◽  
Control Group ◽  
Aged Rats ◽  
Vulnerable Children ◽  
Potential Implication ◽  
Safety And Efficacy ◽  
Anesthesia Management ◽  
Dose Combination ◽  
Old Rats ◽  
Kidney Liver

The efficiency of many anesthetic regimens is controversial, with side effects especially in the vulnerable children and old population. The study aimed to evaluate the safety and efficacy of low-dose combination of ketamine, fentanyl, and dexmedetomidine (KFD) for anesthesia and analgesia in the neonatal and elderly rats. KFD rapidly induced anesthesia and analgesia in either postnatal days 6 (P6) or 13 months (13M) old rats. Meanwhile, KFD administration had no adverse effects on the cardiovascular and respiratory systems. Compared with control group, there were no distinct morphologic changes in kidney, liver, and brain in KFD group. Moreover, administration of KFD had no influence on hepatic and renal function in rats of both ages. Furthermore, there was no obvious difference in cognitive function between control and KFD groups. These results indicated that the administration of KFD combination offered safe and efficient anesthesia. Collectively, our results suggest the potential implication of the KFD combination in anesthesia management.

Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-κB in aged rats

2006 ◽  
Vol 127 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Kyung Jin Jung ◽  
Ji Young Kim ◽  
Yani Zou ◽  
You Jung Kim ◽  
Byung Pal Yu ◽  
...  
Keyword(s):  
Low Dose ◽  
Aged Rats ◽  
Short Term ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

2018 ◽  
Vol 73 (7) ◽  
pp. 845-852 ◽  
Author(s):  
Tea Shavlakadze ◽  
Jiang Zhu ◽  
Sharon Wang ◽  
Weihua Zhou ◽  
Bret Morin ◽  
...  
Keyword(s):  
Low Dose ◽  
Aged Rats ◽  
Related Gene ◽  
Short Term ◽  
Kidney Pathology ◽  
Age Related

Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats

1994 ◽  
Vol 16 (4) ◽  
pp. 529-534 ◽  
Author(s):  
Kiyonri Yamaoka ◽  
Rei Edamatsu ◽  
Takehiko Itoh ◽  
Mori Akitane
Keyword(s):  
Low Dose ◽  
Brain Cortex ◽  
Aged Rats ◽  
X Ray

Effects of aging on cerebral vascular responses to serotonin in rats

1993 ◽  
Vol 264 (6) ◽  
pp. H2136-H2140 ◽  
Author(s):  
M. A. Hajdu ◽  
R. T. McElmurry ◽  
D. D. Heistad ◽  
G. L. Baumbach
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Low Dose ◽  
Cerebral Arteries ◽  
High Dose ◽  
Aged Rats ◽  
Adult Rats ◽  
Effects Of Aging

The purpose of this study was to examine effects of aging on responses of large cerebral arteries to serotonin. We measured cerebral microvascular pressure (with a micropipette and servo-null method), diameter of pial arterioles, and cerebral blood flow (microspheres) in adult (12- to 14-mo-old, n = 15) and aged (24- to 27-mo-old, n = 14) Wistar rats. Responses to intra-atrial infusion of serotonin (5 and 50 micrograms.kg-1.min-1) were examined. Infusion of the low dose of serotonin decreased mean arterial pressure and pial arteriolar pressure in adult and aged rats to similar levels. Cerebral blood flow was not reduced in adult or aged rats during infusion of the low dose of serotonin. The high dose of serotonin did not affect mean arterial pressure but reduced pial arteriolar pressure [from 46 +/- 4 to 23 +/- 2 (SE) in adult rats and from 52 +/- 3 to 18 +/- 4 mmHg in aged rats]. The high dose of serotonin increased large-artery resistance from 0.9 +/- 0.1 to 1.6 +/- 0.2 in adult rats and from 0.9 +/- 0.1 to 2.7 +/- 0.6 mmHg.ml-1.min.100 g in aged rats. Cerebral blood flow was reduced significantly in aged rats (from 59 +/- 3 to 41 +/- 6 ml.min-1.100 g-1), but not in adult rats, during infusion of the high dose of serotonin. We conclude that aging augments constrictor responses of large cerebral arteries to intravascular serotonin, which results in a reduction of cerebral blood flow in aged but not adult rats.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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