Role of genetic variants of deleted in colorectal carcinoma (DCC) polymorphisms and esophageal and gastric cancers risk in Kashmir Valley and meta-analysis

Tumor Biology ◽  
2013 ◽  
Vol 34 (5) ◽  
pp. 3049-3057 ◽  
Author(s):  
Manzoor Ahmad Malik ◽  
Annapurna Gupta ◽  
Showkat Ali Zargar ◽  
Balraj Mittal
Keyword(s):  
Colorectal Carcinoma ◽  
Genetic Variants ◽  
Meta Analysis ◽  
Kashmir Valley ◽  
Gastric Cancers ◽  
Deleted In Colorectal Carcinoma

scholarly journals Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies

2020 ◽  
Vol 17 (21) ◽  
pp. 8010
Author(s):  
Ignacio Hernández-García ◽  
Antonio-Javier Chamorro ◽  
Hugo Guillermo Ternavasio-de la Vega ◽  
Cristina Carbonell ◽  
Miguel Marcos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Genetic Variants ◽  
Autistic Spectrum Disorder ◽  
Association Studies ◽  
Meta Analysis ◽  
Spectrum Disorder ◽  
Current Evidence ◽  
Triplet Repeat ◽  
Autistic Spectrum

Autistic spectrum disorder (ASD) is a complex neurodevelopmental disability with a genetic basis, and several studies have suggested a potential role of the reelin gene (RELN) in ASD susceptibility. Accordingly, genetic association studies have explored this potential association, but the results have been controversial thus far. For this reason, we assessed the association of four genetic variants of RELN (the 5′UTR CGG triplet repeat and polymorphisms rs736707, rs362691, and rs2229864) with ASD by means of a systematic review and meta-analysis. We retrieved studies comparing the distribution of the above-mentioned genetic variants between ASD patients and healthy controls. A meta-analysis was conducted using a random effects model, and calculations of the odds ratios (ORs) and confidence intervals (CIs) were performed. A sensitivity analysis and tests to determine the heterogeneity of the results were also performed. Eleven previous studies fulfilled the inclusion criteria and analyzed the association of the above-mentioned genetic variants and ASD. We did not find any significant association between the allele or genotype frequencies of the analyzed polymorphisms and ASD, and large heterogeneity was found for the rs736707 polymorphism. Moreover, no significant differences were found between the 5′UTR triplet repeat and this disorder. In light of current evidence, no single genetic variant within this gene is clearly associated with the development of ASD, and ethnic differences may explain part of the observed heterogeneity. Larger studies among different ethnic groups are needed to establish the role of specific genetic variants within RELN in the etiology of this disorder.

scholarly journals Alterations in the deleted in colorectal carcinoma gene in human primary leukemia

Blood ◽  
1993 ◽  
Vol 82 (3) ◽  
pp. 927-930 ◽  
Author(s):  
K Miyake ◽  
K Inokuchi ◽  
K Dan ◽  
T Nomura
Keyword(s):  
Colorectal Carcinoma ◽  
Lymphocytic Leukemia ◽  
Myelogenous Leukemia ◽  
Pcr Analysis ◽  
Allelic Loss ◽  
Acute Myelogenous ◽  
Dcc Gene ◽  
Polymerase Chain ◽  
Deleted In Colorectal Carcinoma

Abstract To evaluate the role of the deleted in colorectal carcinoma (DCC) gene in leukemogenesis, we examined loss of heterozygosity (LOH) in the DCC gene in 64 primary human leukemias using Southern blot analysis and examined the expression of the DCC gene using reverse transcriptase- polymerase chain reaction (RT-PCR) analysis. Allelic loss in the DCC gene was observed in two patients (6%, 2 of 35 informative cases), and expression of the DCC gene was reduced or absent in 8 of 26 (31%) patients with acute myelogenous leukemia (AML), 3 of 9 (33%) patients with acute lymphocytic leukemia (ALL), and 7 of 29 (24%) patients with chronic myelogenous leukemia (CML). Moreover, in one ALL patient with absent DCC expression at diagnosis, its expression became normal after performing chemotherapy and achieving remission. These findings suggest that inactivation of the DCC gene contributes to some instances of leukemogenesis.

scholarly journals Alterations in the deleted in colorectal carcinoma gene in human primary leukemia

Blood ◽  
1993 ◽  
Vol 82 (3) ◽  
pp. 927-930 ◽  
Author(s):  
K Miyake ◽  
K Inokuchi ◽  
K Dan ◽  
T Nomura
Keyword(s):  
Colorectal Carcinoma ◽  
Lymphocytic Leukemia ◽  
Myelogenous Leukemia ◽  
Pcr Analysis ◽  
Allelic Loss ◽  
Acute Myelogenous ◽  
Dcc Gene ◽  
Polymerase Chain ◽  
Deleted In Colorectal Carcinoma

To evaluate the role of the deleted in colorectal carcinoma (DCC) gene in leukemogenesis, we examined loss of heterozygosity (LOH) in the DCC gene in 64 primary human leukemias using Southern blot analysis and examined the expression of the DCC gene using reverse transcriptase- polymerase chain reaction (RT-PCR) analysis. Allelic loss in the DCC gene was observed in two patients (6%, 2 of 35 informative cases), and expression of the DCC gene was reduced or absent in 8 of 26 (31%) patients with acute myelogenous leukemia (AML), 3 of 9 (33%) patients with acute lymphocytic leukemia (ALL), and 7 of 29 (24%) patients with chronic myelogenous leukemia (CML). Moreover, in one ALL patient with absent DCC expression at diagnosis, its expression became normal after performing chemotherapy and achieving remission. These findings suggest that inactivation of the DCC gene contributes to some instances of leukemogenesis.

Chronic Pain: Fundamental Scientific Considerations, Specifically for Legal Claims

2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth
Keyword(s):  
Health Outcomes ◽  
Pain Perception ◽  
Driving Forces ◽  
Psychological Treatment ◽  
Dominant Role ◽  
Meta Analysis ◽  
General Medicine ◽  
Pain Syndrome ◽  
Problematic Relationship

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.

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