Association of genetic variants of cancer stem cell gene CD44 haplotypes with gallbladder cancer susceptibility in North Indian population

Tumor Biology ◽  
2013 ◽  
Vol 35 (3) ◽  
pp. 2583-2589 ◽  
Author(s):  
Kiran Lata Sharma ◽  
Anu Yadav ◽  
Annapurna Gupta ◽  
Sonam Tulsayan ◽  
Vijay Kumar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Gallbladder Cancer ◽  
Genetic Variants ◽  
Indian Population ◽  
Cancer Susceptibility ◽  
North Indian Population ◽  
Cell Gene ◽  
Stem Cell Gene

Association of cancer stem cell markers genetic variants with gallbladder cancer susceptibility, prognosis, and survival

Tumor Biology ◽  
2015 ◽  
Vol 37 (2) ◽  
pp. 1835-1844 ◽  
Author(s):  
Anu Yadav ◽  
Annapurna Gupta ◽  
Neeraj Rastogi ◽  
Sushma Agrawal ◽  
Ashok Kumar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Gallbladder Cancer ◽  
Genetic Variants ◽  
Cancer Susceptibility ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers

Association of Potentially Functional Genetic Variants of PLCE1 with Gallbladder Cancer Susceptibility in North Indian Population

2013 ◽  
Vol 44 (4) ◽  
pp. 436-443 ◽  
Author(s):  
Kiran Lata Sharma ◽  
Meenakshi Umar ◽  
Manmohan Pandey ◽  
Sanjeev Misra ◽  
Ashok Kumar ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Genetic Variants ◽  
Indian Population ◽  
Cancer Susceptibility ◽  
North Indian Population

scholarly journals Association of miR-27a, miR-181a and miR-570 genetic variants with gallbladder cancer susceptibility on North indian population

2014 ◽  
Vol 7 (Suppl 1) ◽  
pp. P17 ◽  
Author(s):  
Annapurna Gupta ◽  
Kiran L Sharma ◽  
Annu Yadav ◽  
Vijay Kumar ◽  
Sanjeev Misra ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Genetic Variants ◽  
Indian Population ◽  
Cancer Susceptibility ◽  
North Indian Population

scholarly journals Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases

2019 ◽  
Vol 178 (2) ◽  
pp. 251-261
Author(s):  
Zhe-Bin Liu ◽  
Nader E. Ezzedine ◽  
Agda K. Eterovic ◽  
Joe E. Ensor ◽  
Helen J. Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Gene Mutations ◽  
Breast Cancer Stem Cell ◽  
Circulating Free Dna ◽  
Free Dna ◽  
Cell Gene ◽  
Stem Cell Gene

scholarly journals Identification of a Novel Stem Cell Subtype for Clear Cell Renal Cell Carcinoma Based on Stem Cell Gene Profiling

2021 ◽  
Vol 11 ◽  
Author(s):  
Hongzhi Wang ◽  
Hanjiang Xu ◽  
Quan Cheng ◽  
Chaozhao Liang
Keyword(s):  
Renal Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Renal Cancer ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Gene Sets ◽  
Cell Gene ◽  
Stem Cell Gene

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and is characterized by high rates of metastasis. Cancer stem cell is a vital cause of renal cancer metastasis and recurrence. However, little is known regarding the change and the roles of stem cells during the development of renal cancer. To clarify this problem, we developed a novel stem cell clustering strategy. Based on The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) genomic datasets, we used 19 stem cell gene sets to classify each dataset. A machine learning method was used to perform the classification. We classified ccRCC into three subtypes—stem cell activated (SC-A), stem cell dormant (SC-D), and stem cell excluded (SC-E)—based on the expressions of stem cell-related genes. Compared with the other subtypes, C2(SC-A) had the highest degree of cancer stem cell concentration, the highest level of immune cell infiltration, a distinct mutation landscape, and the worst prognosis. Moreover, drug sensitivity analysis revealed that subgroup C2(SC-A) had the highest sensitivity to immunotherapy CTLA-4 blockade and the vascular endothelial growth factor receptor (VEGFR) inhibitor sunitinib. The identification of ccRCC subtypes based on cancer stem cell gene sets demonstrated the heterogeneity of ccRCC and provided a new strategy for its treatment.

Cancer stem cell gene signature of ovarian tumor side populations

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 5546-5546
Author(s):  
L. Ozbun ◽  
V. Vathipadiekal ◽  
M. E. Radonovich ◽  
C. Pise-Masison ◽  
D. Saxena ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Ovarian Tumor ◽  
Gene Signature ◽  
Cell Gene ◽  
Stem Cell Gene
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