Prognostic significance of the recurrence pattern and risk factors for recurrence in patients with proximal gastric cancer who underwent curative gastrectomy

Tumor Biology ◽  
2015 ◽  
Vol 36 (8) ◽  
pp. 6191-6199 ◽  
Author(s):  
Ahmet Bilici ◽  
Fatih Selcukbiricik
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Prognostic Significance ◽  
Recurrence Pattern ◽  
Proximal Gastric Cancer ◽  
Curative Gastrectomy ◽  
Risk Factors For Recurrence

scholarly journals Risk evaluation of splenic hilar or splenic artery lymph node metastasis and survival analysis for patients with proximal gastric cancer after curative gastrectomy: a retrospective study

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Peng Ding ◽  
Ziming Gao ◽  
Chen Zheng ◽  
Junqing Chen ◽  
Kai Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Splenic Artery ◽  
Proximal Gastric Cancer ◽  
Curative Gastrectomy ◽  
Node Metastases ◽  
Gastric Cancer Patients

Abstract Background As splenectomy and spleen-preserving lymphadenectomy are performed only in some proximal gastric cancer patients, it is difficult to identify patients who have undergone radical gastrectomy with or without splenic hilar (No.10) or splenic artery (No.11) lymph node metastases. We aimed to determine the risk factors for No.10 and No.11 lymph node metastases and evaluate the survival significance of No.10 and No.11 lymph node dissection in advanced proximal gastric cancer patients. Methods A total of 873 advanced proximal gastric cancer patients who underwent curative gastrectomy with or without splenectomy or pancreaticosplenectomy were analyzed retrospectively. The clinicopathological characteristics of 152 patients who underwent splenectomy or pancreaticosplenectomy were analyzed to determine the risk factors for No.10 and No.11 lymph node metastases. The survival difference between patients with No.10 and No.11 lymph node dissections and those who did not undergo these dissections were compared. Results Patients with No.10 and No.11 lymph node metastases had very poor prognoses. Tumor invasion of the greater curvature and No.2 and No.4 lymph node metastases were independent risk factors for No.10 and No.11 lymph node metastases. No survival differences were evident between patients with No.10 and No.11 lymph node metastases who underwent No.10 and No.11 lymph node dissections and those who did not undergo these dissections but were at high risks of No.10 and No.11 lymph node metastases. Conclusions Splenic hilar or splenic artery lymph node dissection was not associated with increased survival, in proximal gastric cancer patients without direct cancer invasion of the spleen and pancreas, regardless of whether splenectomy, pancreaticosplenectomy, or spleen-preserving lymphadenectomy was performed.

Prognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy

2019 ◽  
Vol 42 (4) ◽  
pp. 209-216 ◽  
Author(s):  
Ahmet Bilici ◽  
Fatih Selcukbiricik ◽  
Mesut Seker ◽  
Basak B. Oven ◽  
Omer Fatih Olmez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Curative Gastrectomy ◽  
Metastatic Lymph ◽  
Node Ratio

Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 60-60
Author(s):  
Ahmet Bilici ◽  
Dincer Aydin ◽  
Dilek Yavuzer ◽  
Hatice Odabas ◽  
Ozlem Ercelep ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multivariate Analysis ◽  
Molecular Marker ◽  
Cancer Progression ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Prognostic Indicator ◽  
Curative Gastrectomy ◽  
Prognostic Importance ◽  
Gastric Cancer Patients

60 Background: Tumor invasion and metastasis are complex processes, involving regulation at the molecular level of adhesive molecules, proteolitic enzymes, and cell growth and angiogenesis factors. A Disintegrin and Metalloproteinase (ADAM)17 has been indicated to be indispensable regulator of celular event from proliferation to migration.Although prognostic importance of ADAM17 expression has been investigated in several tumors, its clinical utility as a useful prognostic molecular marker remains unclearin gastric cancer.In the present study, we evaluated the expression of ADAM17 and its prognostic significance in gastric cancer patients after surgery. Methods: Prognostic significance of ADAM17 expression was analyzed by immunohistochemically in 158 patients with gastric cancer and the relationship between its expression and clinicopathological factors was also evaluated. Results: High expression of ADAM17 was detected in 81 patients(51%),while low expression was found in 77 cases (49%). There was significant correlation between gender, histology, lymph node metastasis, vascular invasion, the presence of recurrence and high ADAM17 expression. Recurrence in patients with high ADAM17 expression was significantly higher than that for patients with low ADAM17 expression(p=0.032). The median disease-free survival (DFS) time for patients with high ADAM17 expressed tumors were worse than those of patients with low ADAM17 expressed tumor (16.6 vs. 44.2 months, p=0.004).In addition, patients with low ADAM17 expression had a higher median overall survival (OS)interval than those of high ADAM17 expressed patients (49.6 vs. 26.9 months, p=0.019). Multivariate analysis indicated that the rate of ADAM17 expression was an independent prognostic factor for DFS, in addition to known important clinicopathological prognostic indicator for DFS. But its' prognostic importance could not be proved by multivariate analysis for OS. Conclusions: The potential value of ADAM17 expression as a useful molecular marker in gastric cancer progression should be evaluated comprehensively,it may predict recurrence and poor prognosis in patients with gastric cancer after curative resection.

Characteristics of long-term survivors in stage III gastric cancer patients.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 163-163
Author(s):  
Youjin Jang ◽  
Youngjae Mok
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Significance ◽  
Lymph Node Involvement ◽  
Peritoneal Recurrence ◽  
Stage Iii ◽  
Recurrence Pattern ◽  
Hematogenous Recurrence ◽  
Gastric Cancer Patients

163 Background: Stage III gastric cancer patients had poor prognosis. This study aims to evaluate prognostic factor of stage III gastric cancer. Methods: We retrospectively studied 126 patients who were treated for stage III gastric cancer from Jan. 2007 to Dec. 2010 at Korea University Hospital and performed complete follow up for five years. Long-term survivor was defined more than five years survivor after gastrectomy. Results: Long-term survivor was 70 patients (55.6%). Tumor size, lymph node involvement, lymphatic invasion, venous invasion and neural invasion had prognostic significance on univariate analysis. But location of tumor, gross type, depth of invasion, TNM stage, combine resection, complication, histologic differentiation, type of operation and adjuvant treatment had no prognostic significance. The most common recurrence pattern was peritoneal recurrence (57.4%) according to analysis of recurrence pattern. The disease free survival according recurrence pattern was peritoneal recurrence (21.3 months), hematogenous recurrence (32.1 months), distant lymph node recurrence (12.0 months) and locoregional (12 months). The disease specific survival according recurrence pattern was peritoneal recurrence (9.2 months), hematogenous recurrence (11.3 months), distant lymph node recurrence (16.2 months) and locoregional (26.9 months). Conclusions: Lymph node involvement were the most significant prognostic factors on stage III gastric cancer after curative resection. Therefore, postoperative surveillance and adjuvant therapy were very carefully selected in stage III gastric cancer patient with extensive lymph node metastasis.

scholarly journals The Risk Factors of Reflux Complication after Gastrectomy for Proximal Gastric Cancer

2010 ◽  
Vol 79 (4) ◽  
pp. 246
Author(s):  
Seung-Jin Kwag ◽  
Sang-Ho Jung ◽  
Young-Jun Lee ◽  
Chi-Young Jung ◽  
Soon-Tae Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Proximal Gastric Cancer
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