The Risk Factors of Reflux Complication after Gastrectomy for Proximal Gastric Cancer

Abstract Background As splenectomy and spleen-preserving lymphadenectomy are performed only in some proximal gastric cancer patients, it is difficult to identify patients who have undergone radical gastrectomy with or without splenic hilar (No.10) or splenic artery (No.11) lymph node metastases. We aimed to determine the risk factors for No.10 and No.11 lymph node metastases and evaluate the survival significance of No.10 and No.11 lymph node dissection in advanced proximal gastric cancer patients. Methods A total of 873 advanced proximal gastric cancer patients who underwent curative gastrectomy with or without splenectomy or pancreaticosplenectomy were analyzed retrospectively. The clinicopathological characteristics of 152 patients who underwent splenectomy or pancreaticosplenectomy were analyzed to determine the risk factors for No.10 and No.11 lymph node metastases. The survival difference between patients with No.10 and No.11 lymph node dissections and those who did not undergo these dissections were compared. Results Patients with No.10 and No.11 lymph node metastases had very poor prognoses. Tumor invasion of the greater curvature and No.2 and No.4 lymph node metastases were independent risk factors for No.10 and No.11 lymph node metastases. No survival differences were evident between patients with No.10 and No.11 lymph node metastases who underwent No.10 and No.11 lymph node dissections and those who did not undergo these dissections but were at high risks of No.10 and No.11 lymph node metastases. Conclusions Splenic hilar or splenic artery lymph node dissection was not associated with increased survival, in proximal gastric cancer patients without direct cancer invasion of the spleen and pancreas, regardless of whether splenectomy, pancreaticosplenectomy, or spleen-preserving lymphadenectomy was performed.

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Prognostic significance of the recurrence pattern and risk factors for recurrence in patients with proximal gastric cancer who underwent curative gastrectomy

Tumor Biology ◽

10.1007/s13277-015-3304-7 ◽

2015 ◽

Vol 36 (8) ◽

pp. 6191-6199 ◽

Cited By ~ 13

Author(s):

Ahmet Bilici ◽

Fatih Selcukbiricik

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Prognostic Significance ◽

Recurrence Pattern ◽

Proximal Gastric Cancer ◽

Curative Gastrectomy ◽

Risk Factors For Recurrence

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Gastric Cancer Risk Factors Associated With EU and CELAC Populations

Case Medical Research ◽

10.31525/ct1-nct03957031 ◽

2019 ◽

Author(s):

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Cancer Risk ◽

Gastric Cancer Risk ◽

Cancer Risk Factors ◽

Factors Associated

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Exploring the interactions between Hp infection and other risk factors of gastric cancer: a pooled analysis in the Stomach cancer Pooling ( StoP ) Project

International Journal of Cancer ◽

10.1002/ijc.33678 ◽

2021 ◽

Author(s):

Giulia Collatuzzo ◽

Claudio Pelucchi ◽

Eva Negri ◽

Lizbeth López‐Carrillo ◽

Shoichiro Tsugane ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Stomach Cancer ◽

Pooled Analysis

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Prevalence and risk factors of Helicobacter pylori infection in Wuwei, a high‐risk area for gastric cancer in northwest China: An all‐ages population‐based cross‐sectional study

Helicobacter ◽

10.1111/hel.12810 ◽

2021 ◽

Author(s):

Xiaofeng Wang ◽

Xiaochuang Shu ◽

Qiang Li ◽

Youpeng Li ◽

Zhaofeng Chen ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Helicobacter Pylori ◽

Northwest China ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Risk Area ◽

Cross Sectional ◽

High Risk Area

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Laparoscopic proximal gastrectomy with double-tract reconstruction for upper third gastric cancer

BMC Surgery ◽

10.1186/s12893-021-01153-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shuo-meng Xiao ◽

Ping Zhao ◽

Zhi Ding ◽

Rui Xu ◽

Chao Yang ◽

...

Keyword(s):

Gastric Cancer ◽

Proximal Gastrectomy ◽

Operation Time ◽

Nutrition Status ◽

Proximal Gastric Cancer ◽

Double Tract Reconstruction ◽

Significant Difference ◽

Laparoscopic Proximal Gastrectomy ◽

Gastric Cancer Patients ◽

Upper Third

Abstract Background Proximal gastrectomy with double-tract reconstruction (DTR) has been used for upper third gastric cancer as a function-preserving procedure. However, the safety and feasibility of laparoscopic proximal gastrectomy (LPG) with DTR remain uncertain. This study compared open proximal gastrectomy (OPG) with DTR and LPG with DTR for proximal gastric cancer. Methods Sixty-four patients who had undergone OPG with DTR and forty-six patients who had undergone LPG with DTR were enrolled in this case–control study. The clinical characteristics, surgical outcomes and postoperative nutrition index were analysed retrospectively. Results The operation time was significantly longer in the LGP group than in the OPG group (258.3 min vs 205.8 min; p = 0.00). However, the time to first flatus and postoperative hospital stay were shorter in the LPG group [4.0 days vs 3.5 days (p = 0.00) and 10.6 days vs 9.2 days (p = 0.001), respectively]. No significant difference was found between the two groups in the number of retrieved lymph nodes, complications or reflux oesophagitis. The nutrition status was assessed using the haemoglobin, albumin, prealbumin and weight levels from pre-operation to six months after surgery. No significant difference was found between the groups. Conclusion LPG with DTR can be safely performed for proximal gastric cancer patients by experienced surgeons.

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