Elevated serum microRNA-122/222 levels are potential diagnostic biomarkers in Egyptian patients with chronic hepatitis C but not hepatic cancer

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 9865-9874 ◽  
Author(s):  
Tarek M. K. Motawi ◽  
Nermin A. H. Sadik ◽  
Olfat G. Shaker ◽  
Maggy H. Ghaleb
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Elevated Serum ◽  
Hepatic Cancer ◽  
Diagnostic Biomarkers ◽  
Serum Microrna ◽  
Egyptian Patients

Impact of nitazoxanide on sustained virologic response in Egyptian patients with chronic hepatitis C genotype 4

2016 ◽  
Vol 28 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Mohamed A.S. Kohla ◽  
Hala El-Said ◽  
Ashraf El-Fert ◽  
Nermine Ehsan ◽  
Sameera Ezzat ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Sustained Virologic Response ◽  
Virologic Response ◽  
Genotype 4 ◽  
Egyptian Patients

The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin-induced anaemia in chronic hepatitis C Egyptian patients

2017 ◽  
Vol 44 (9) ◽  
pp. 965-968 ◽  
Author(s):  
Ehab S El Desoky ◽  
Alaa T Abdelhafez ◽  
Jessica Cusato ◽  
Sherif I Kamel ◽  
Abeer MR Hussein ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Egyptian Patients

scholarly journals The Association of XRCC1 Gene Polymorphisms and Chronic Hepatitis C Induced Insulin Resistance in Egyptian Patients

Cells ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 185
Author(s):  
Salwa Abo El-khair ◽  
Mona Arafa ◽  
Tarek Besheer ◽  
Ahmed El-Eraky ◽  
Ayman Elsamanoudy
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Gene Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Xrcc1 Gene ◽  
Egyptian Patients ◽  
Pcr Rflp ◽  
Chronic Hcv

Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR related to chronic hepatitis C virus (HCV) infection in Egyptian patients. In a case-control study, a total of 210 subjects, including 140 chronic HCV patients (87 patients with IR and 53 without IR) and 70 healthy controls, were included. Two genetic polymorphisms (c.1254C > T and c.1517G > C) of the XRCC1 gene were genotyped via the PCR-restriction fragment length polymorphism (PCR-RFLP) technique. The result of the current study revealed that these two single nucleotide polymorphisms (SNPs) have statistically significant influences on susceptibility to IR in chronic HCV infected Egyptian patients. It could be concluded that c.1254C > T, the TT genotype, CT/CC carriers as well as c.1517G > C, the CC genotype and GC/GG carriers might be associated with increased IR susceptibility. Moreover, T-allele of c.1254C > T and the C-allele of c.1517G > C genetic variants might influence the susceptibility.

scholarly journals Significance of iron reduction for the therapy of chronic hepatitis C

2005 ◽  
Vol 62 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Darko Nozic ◽  
Bela Balint ◽  
Nebojsa Stankovic ◽  
Jovan Dimitrijevic ◽  
Gorana Neskovic
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Iron Overload ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Iron Reduction ◽  
Elevated Serum ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Iron Deposits

Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection.

scholarly journals Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hala O. El-Mesallamy ◽  
Nadia M. Hamdy ◽  
Hanan H. Rizk ◽  
Abdel-Rahman El-Zayadi
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Orphan Receptor ◽  
Necrosis Factor Alpha ◽  
Factors Affecting ◽  
Fibrosis Progression ◽  
Egyptian Patients ◽  
Factor Alpha ◽  
Nonobese Patients

Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha (TNF-α). Serum apelin levels were significantly higher in patients with CHC with median value (3.25) when compared with controls (1.11), atP<0.0001, with significant apelin variations among asymptomatic carriers (ASC), fibrosis, and cirrhosis patients, and also among obese and nonobese patients. Multiple regression analysis depicted that BMI, triglycerides, and total cholesterol were independent correlation factors to apelin levels, whereas TNF-αwas found to be significantly negatively correlated to adjusted apelin in CHC patients (r=−0.5944,P<0.0001). IR was positively correlated to adjusted apelin in CHC patients (r=0.2663,P<0.05).Conclusion. Apelin level varies among stages of CHC, which may contribute to fibrosis progression. In addition, obesity and IR could act as comorbid factors affecting apelin level in patients with CHC.

Circulating microRNAs as predictive biomarkers for liver disease progression of chronic hepatitis C (genotype‐4) Egyptian patients

2018 ◽  
Vol 91 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Mohamed El‐Hefny ◽  
Shawky Fouad ◽  
Tarek Hussein ◽  
Rehab Abdel‐Hameed ◽  
Heba Effat ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Disease Progression ◽  
Chronic Hepatitis C ◽  
Predictive Biomarkers ◽  
Genotype 4 ◽  
Circulating Micrornas ◽  
Liver Disease Progression ◽  
Egyptian Patients
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