Elevated serum microRNA-122/222 levels are potential diagnostic biomarkers in Egyptian patients with chronic hepatitis C but not hepatic cancer

Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR related to chronic hepatitis C virus (HCV) infection in Egyptian patients. In a case-control study, a total of 210 subjects, including 140 chronic HCV patients (87 patients with IR and 53 without IR) and 70 healthy controls, were included. Two genetic polymorphisms (c.1254C > T and c.1517G > C) of the XRCC1 gene were genotyped via the PCR-restriction fragment length polymorphism (PCR-RFLP) technique. The result of the current study revealed that these two single nucleotide polymorphisms (SNPs) have statistically significant influences on susceptibility to IR in chronic HCV infected Egyptian patients. It could be concluded that c.1254C > T, the TT genotype, CT/CC carriers as well as c.1517G > C, the CC genotype and GC/GG carriers might be associated with increased IR susceptibility. Moreover, T-allele of c.1254C > T and the C-allele of c.1517G > C genetic variants might influence the susceptibility.

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HLA Status and Antithyroid Autoantibodies in Egyptian Patients with Chronic Hepatitis C Virus Infection

Euroasian Journal of Hepato-Gastroenterology ◽

10.5005/jp-journals-10018-1003 ◽

2011 ◽

Vol 1 (1) ◽

pp. 15-18

Author(s):

Yahia Zakaria Gad ◽

Mahmoud El-Bendary ◽

Mona Mahmoud Arafa ◽

Zakaria Fawzy Lotfy

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Chronic Hepatitis C ◽

Hepatitis C Virus Infection ◽

Egyptian Patients ◽

Chronic Hepatitis C Virus ◽

Antithyroid Autoantibodies

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Significance of iron reduction for the therapy of chronic hepatitis C

Vojnosanitetski pregled ◽

10.2298/vsp0502161n ◽

2005 ◽

Vol 62 (2) ◽

pp. 161-164 ◽

Cited By ~ 1

Author(s):

Darko Nozic ◽

Bela Balint ◽

Nebojsa Stankovic ◽

Jovan Dimitrijevic ◽

Gorana Neskovic

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Iron Overload ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Iron Reduction ◽

Elevated Serum ◽

Chronic Viral Hepatitis ◽

Viral Hepatitis C ◽

Iron Deposits

Background. It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposits in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connected with the decreased response to interferon-alfa therapy for chronic viral hepatitis C. Recent introduction of pegylated interferons plus ribavirin has improved the therapeutic response, so it is now possible to cure more than 50% of the patients. Case report. Three patients with chronic hepatitis C and iron overload were presented. Iron reduction therapy using phlebotomy or eritrocytapheresis with plasmapheresis was done at different times in regard to specific antiviral therapy or as a sole therapy. Conclusion. It has been shown that iron reduction, sole or combined with antiviral therapy, led to the deacreased aminotransferase serum activity and might have slow down the evolution of chronic hepatitis C viral infection.

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Helicobacter Pylori DNA in Liver Tissues From Chronic Hepatitis C Egyptian Patients

Gastroenterology Research ◽

10.4021/gr356w ◽

2011 ◽

Author(s):

Mahmoud

Keyword(s):

Helicobacter Pylori ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Egyptian Patients ◽

Liver Tissues

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Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

Mediators of Inflammation ◽

10.1155/2011/703031 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Hala O. El-Mesallamy ◽

Nadia M. Hamdy ◽

Hanan H. Rizk ◽

Abdel-Rahman El-Zayadi

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Orphan Receptor ◽

Necrosis Factor Alpha ◽

Factors Affecting ◽

Fibrosis Progression ◽

Egyptian Patients ◽

Factor Alpha ◽

Nonobese Patients

Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha (TNF-α). Serum apelin levels were significantly higher in patients with CHC with median value (3.25) when compared with controls (1.11), atP<0.0001, with significant apelin variations among asymptomatic carriers (ASC), fibrosis, and cirrhosis patients, and also among obese and nonobese patients. Multiple regression analysis depicted that BMI, triglycerides, and total cholesterol were independent correlation factors to apelin levels, whereas TNF-αwas found to be significantly negatively correlated to adjusted apelin in CHC patients (r=−0.5944,P<0.0001). IR was positively correlated to adjusted apelin in CHC patients (r=0.2663,P<0.05).Conclusion. Apelin level varies among stages of CHC, which may contribute to fibrosis progression. In addition, obesity and IR could act as comorbid factors affecting apelin level in patients with CHC.

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